scholarly journals Cardiovascular health metrics from mid‐ to late‐life and risk of dementia: A population‐based study

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Yajun Liang ◽  
Tiia Ngandu ◽  
Tiina Laatikainen ◽  
Hilkka Soininen ◽  
Jaakko Tuomilehto ◽  
...  
2021 ◽  
Vol 77 (18) ◽  
pp. 3258
Author(s):  
Zahra Azizi ◽  
Louise Pilote ◽  
Valeria Raparelli ◽  
Colleen Norris ◽  
Karolina Kublickiene ◽  
...  

Author(s):  
Priya Palta ◽  
Michael Griswold ◽  
Radhikesh Ranadive ◽  
Karen Bandeen-Roche ◽  
Aaron R Folsom ◽  
...  

Abstract Background We examined the relationship of midlife cardiovascular health (CVH) with late-life robustness among men and women and the impact of survivorship bias on sex-differences in robustness. Methods Prospective analysis of 15,744 participants aged 45-64 (Visit 1 median age: 54 years, 55% female, 27% Black) in 1987-1989 from the population-based ARIC Study. CVH was operationalized according to the Life’s Simple 7 (LS7) metric of health behaviors (smoking, weight, physical activity, diet, cholesterol, blood pressure, and glucose); each behavior was scored as ideal (2 points), intermediate (1 point), or poor (0 points) and summed. Late-life robust/pre-frail/frailty was defined at Visit 5 (2011-2013). Multinomial regression estimated relative prevalence ratios (RPR) of late-life robustness/pre-frailty/frailty/death across overall midlife LS7 score and components, for the full Visit 1 sample. Separate analyses considered Visit 5 survivors only. Results For each one-unit greater midlife LS7 score, participants had a 37% higher relative prevalence of being robust versus frail (overall RPR=1.37, [95% CI: 1.30-1.44]; women=1.45 [1.36-1.54]; men=1.24 [1.13-1.36]). Among the full Visit 1 sample, women had a similar one-level higher robustness category prevalence (RPR=1.35 [95% CI: 1.32-1.39]) than men (RPR=1.31 [95% CI: 1.27-1.35]) for every one-unit higher midlife LS7 score. Among survivors, men were more likely to be robust than women at lower LS7 levels; differences were attenuated and not statistically different at higher midlife LS7 levels. Conclusions Midlife CVH is positively associated with robustness in late-life among men and women. Accounting for mortality in part explains documented sex-differences in robustness across all levels of LS7.


2014 ◽  
Vol 22 (11) ◽  
pp. 1292-1306 ◽  
Author(s):  
Aude Manetti ◽  
Nicolas Hoertel ◽  
Yann Le Strat ◽  
Jean-Pierre Schuster ◽  
Cédric Lemogne ◽  
...  

2017 ◽  
Vol 228 ◽  
pp. 23-30 ◽  
Author(s):  
Michal Benderly ◽  
Angela Chetrit ◽  
Havi Murad ◽  
Kathleen Abu-Saad ◽  
Michal Gillon-Keren ◽  
...  

2003 ◽  
Vol 51 (8) ◽  
pp. 1105-1110 ◽  
Author(s):  
Henning Tiemeier ◽  
Monique M. B. Breteler ◽  
Nicole M. Van Popele ◽  
Albert Hofman ◽  
Jacqueline C. M. Witteman

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