scholarly journals Analysis of structural and functional connectivity MRI biomarkers in Alzheimer’s disease

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Dirk Smeets ◽  
Nuno Pedrosa de Barros ◽  
Thibo Billiet ◽  
Diana M. Sima ◽  
Rafat Mohtasib ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Functional Connectivity Mri

Altered Functional Connectivity of the Marginal Division in Alzheimer’s Disease

2014 ◽  
Vol 11 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Zengqiang Zhang ◽  
Yong Liu ◽  
Bo Zhou ◽  
Jinlong Zheng ◽  
Hongxiang Yao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Marginal Division

scholarly journals Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease

2021 ◽  
pp. 1-6
Author(s):  
Julia Schumacher ◽  
Alan J. Thomas ◽  
Luis R. Peraza ◽  
Michael Firbank ◽  
John T. O’Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Lewy Body ◽  
Cholinergic System ◽  
Structural Changes ◽  
Lewy Body Dementia ◽  
Occipital Cortex ◽  
Nucleus Basalis ◽  
Nucleus Basalis Of Meynert

ABSTRACT Cholinergic deficits are a hallmark of Alzheimer’s disease (AD) and Lewy body dementia (LBD). The nucleus basalis of Meynert (NBM) provides the major source of cortical cholinergic input; studying its functional connectivity might, therefore, provide a tool for probing the cholinergic system and its degeneration in neurodegenerative diseases. Forty-six LBD patients, 29 AD patients, and 31 healthy age-matched controls underwent resting-state functional magnetic resonance imaging (fMRI). A seed-based analysis was applied with seeds in the left and right NBM to assess functional connectivity between the NBM and the rest of the brain. We found a shift from anticorrelation in controls to positive correlations in LBD between the right/left NBM and clusters in right/left occipital cortex. Our results indicate that there is an imbalance in functional connectivity between the NBM and primary visual areas in LBD, which provides new insights into alterations within a part of the corticopetal cholinergic system that go beyond structural changes.

scholarly journals A Winding Road: Alzheimer’s Disease Increases Circuitous Functional Connectivity Pathways

2015 ◽  
Vol 9 ◽  
Author(s):  
John Suckling ◽  
Tiago Simas ◽  
Shayanti Chattopadhyay ◽  
Roger Tait ◽  
Li Su ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity

scholarly journals P2-228: Detection of changes in functional connectivity following Aricept® treatment in Mild Alzheimer's disease subjects

2009 ◽  
Vol 5 (4S_Part_11) ◽  
pp. P327-P327 ◽  
Author(s):  
Shi-Jiang Li ◽  
Douglas B. Ward ◽  
Zhilin Wu ◽  
Jennifer Jones ◽  
Thomas McRae ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity
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