scholarly journals Type 2 diabetes and cardiovascular disease increase the risk of cognitive impairment and accelerate the progression to dementia in Swedish older adults

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Abigail Dove ◽  
Ying Shang ◽  
Giulia Grande ◽  
Erika J Laukka ◽  
Laura Fratiglioni ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Cognitive Impairment

Effect of Advanced Glycation End Products on Cognition in Older Adults with Type 2 Diabetes: Results from a Pilot Clinical Trial

2021 ◽  
pp. 1-11
Author(s):  
Roni Lotan ◽  
Ithamar Ganmore ◽  
Abigail Livny ◽  
Nofar Itzhaki ◽  
Mark Waserman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Pilot Trial ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Global Cognition

Background: Dietary advanced glycation end-products (AGEs) are linked to cognitive decline. However, clinical trials have not tested the effect of AGEs on cognition in older adults. Objective: The aim of the current pilot trial was to examine the feasibility of an intervention to reduce dietary AGEs on cognition and on cerebral blood flow (CBF). Methods: The design is a pilot randomized controlled trial of dietary AGEs reduction in older adults with type 2 diabetes. Seventy-five participants were randomized to two arms. The control arm received standard of care (SOC) guidelines for good glycemic control; the intervention arm, in addition to SOC guidelines, were instructed to reduce their dietary AGEs intake. Global cognition and CBF were assessed at baseline and after 6 months of intervention. Results: At baseline, we found a reverse association between AGEs and cognitive functioning, possibly reflecting the long-term toxicity of AGEs on the brain. There was a significant improvement in global cognition at 6 months in both the intervention and SOC groups which was more prominent in participants with mild cognitive impairment. We also found that at baseline, higher AGEs were associated with increased CBF in the left inferior parietal cortex; however, 6 months of the AGEs lowering intervention did not affect CBF levels, despite lowering AGEs exposure in blood. Conclusion: The current pilot trial focused on the feasibility and methodology of intervening through diet to reduce AGEs in older adults with type 2 diabetes. Our results suggest that participants with mild cognitive impairment may benefit from an intensive dietary intervention.

scholarly journals Creating Effective Self-Management for Older Adults with Type 2 Diabetes and Cognitive Impairment

2015 ◽  
Vol 04 (02) ◽  
pp. 33-41 ◽  
Author(s):  
Cameron J. Camp ◽  
Kathleen Fox ◽  
Michael J. Skrajner ◽  
Vincent Antenucci ◽  
Jessica Haberman
Keyword(s):  
Type 2 Diabetes ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Self Management

scholarly journals An Extended Theory of Planned Behavior Intervention for Older Adults With Type 2 Diabetes and Cardiovascular Disease

2012 ◽  
Vol 20 (3) ◽  
pp. 281-299 ◽  
Author(s):  
Katherine M. White ◽  
Deborah J. Terry ◽  
Carolyn Troup ◽  
Lynn A. Rempel ◽  
Paul Norman ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Theory Of Planned Behavior ◽  
Healthy Eating ◽  
Behavioral Control ◽  
Subjective Norm ◽  
Perceived Behavioral Control

A randomized controlled trial evaluated the effectiveness of a 4-wk extended theory of planned behavior (TPB) intervention to promote regular physical activity and healthy eating among older adults diagnosed with Type 2 diabetes or cardiovascular disease (N= 183). Participants completed TPB measures of attitude, subjective norm, perceived behavioral control, and intention, as well as planning and behavior, at preintervention and 1 wk and 6 wk postintervention for each behavior. No significant time-by-condition effects emerged for healthy eating. For physical activity, significant time-by-condition effects were found for behavior, intention, planning, perceived behavioral control, and subjective norm. In particular, compared with control participants, the intervention group showed short-term improvements in physical activity and planning, with further analyses indicating that the effect of the intervention on behavior was mediated by planning. The results indicate that TPB-based interventions including planning strategies may encourage physical activity among older people with diabetes and cardiovascular disease.

scholarly journals Fetuin-A, Type 2 Diabetes, and Risk of Cardiovascular Disease in Older Adults: The Cardiovascular Health Study

Diabetes Care ◽  
2012 ◽  
Vol 36 (5) ◽  
pp. 1222-1228 ◽  
Author(s):  
M. K. Jensen ◽  
T. M. Bartz ◽  
K. J. Mukamal ◽  
L. Djousse ◽  
J. R. Kizer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Older Adults ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Fetuin A
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