scholarly journals Effects of iron and/or inflammation on regional brain magnetic resonance imaging T1 and T2 in an Alzheimer’s disease mouse model

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Manal Aljuhani ◽  
Azhaar Ashraf ◽  
Elena Kislitsyna ◽  
Rifah Anjum ◽  
Chantal Hubens ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Brain Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Regional Brain ◽  
T1 And T2

scholarly journals Easy Identification of Optimal Coronal Slice on Brain Magnetic Resonance Imaging to Measure Hippocampal Area in Alzheimer’s Disease Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
P. Zach ◽  
A. Bartoš ◽  
A. Lagutina ◽  
Z. Wurst ◽  
P. Gallina ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Brain Magnetic Resonance Imaging ◽  
Control Group ◽  
Resonance Imaging ◽  
Hippocampal Area ◽  
Left And Right ◽  
The Brain

Introduction. Measurement of an- hippocampal area or volume is useful in clinical practice as a supportive aid for diagnosis of Alzheimer’s disease. Since it is time-consuming and not simple, it is not being used very often. We present a simplified protocol for hippocampal atrophy evaluation based on a single optimal slice in Alzheimer’s disease. Methods. We defined a single optimal slice for hippocampal measurement on brain magnetic resonance imaging (MRI) at the plane where the amygdala disappears and only the hippocampus is present. We compared an absolute area and volume of the hippocampus on this optimal slice between 40 patients with Alzheimer disease and 40 age-, education- and gender-mateched elderly controls. Furthermore, we compared these results with those relative to the size of the brain or the skull: the area of the optimal slice normalized to the area of the brain at anterior commissure and the volume of the hippocampus normalized to the total intracranial volume. Results. Hippocampal areas on the single optimal slice and hippocampal volumes on the left and right in the control group were significantly higher than those in the AD group. Normalized hippocampal areas and volumes on the left and right in the control group were significantly higher compared to the AD group. Absolute hippocampal areas and volumes did not significantly differ from corresponding normalized hippocampal areas as well as normalized hippocampal volumes using comparisons of areas under the receiver operating characteristic curves. Conclusion. The hippocampal area on the well-defined optimal slice of brain MRI can reliably substitute a complicated measurement of the hippocampal volume. Surprisingly, brain or skull normalization of these variables does not add any incremental differentiation between Alzheimer disease patients and controls or give better results.

Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease

2021 ◽  
pp. 1-10
Author(s):  
Fabienne Cyprien ◽  
Claudine Berr ◽  
Jerome J. Maller ◽  
Chantal Meslin ◽  
Mélissa Gentreau ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
Brain Magnetic Resonance Imaging ◽  
Late Life ◽  
Community Dwelling ◽  
Resonance Imaging ◽  
Cynical Hostility

Abstract Background Cynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD. Methods In community-dwelling older adults from the French ESPRIT cohort (n = 1388), incident dementia rate according to CH level was monitored during an 8-year follow-up and analyzed using Cox proportional hazards regression models. Brain magnetic resonance imaging volumes were measured at baseline (n = 508). Using automated segmentation procedures (Freesurfer 6.0), the authors assessed brain grey and white volumes on all magnetic resonance imaging scans. They also measured white matter hyperintensities volumes using semi-automated procedures. Mean volumes according to the level of CH were compared using ANOVA. Results Eighty-four participants developed dementia (32 with AD). After controlling for potential confounders, high CH was predictive of AD (HR 2.74; 95% CI 1.10–6.85; p = 0.030) and all dementia types are taken together (HR 2.30; 95% CI 1.10–4.80; p = 0.027). High CH was associated with white matter alterations, particularly smaller anterior corpus callosum volume (p < 0.01) after False Discovery Rate correction, but not with grey matter volumes. Conclusions High CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies.

Prevalence of Sinusitis Detected by Magnetic Resonance Imaging in Subjects with Dementia or Alzheimer’s Disease

2015 ◽  
Vol 12 (10) ◽  
pp. 1006-1011 ◽  
Author(s):  
Minori Yasue ◽  
Saiko Sugiura ◽  
Yasue Uchida ◽  
Hironao Otake ◽  
Masaaki Teranishi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
Resonance Imaging

scholarly journals Quantitative sodium imaging using ultra‐high field magnetic resonance imaging in patients with Alzheimer's disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Alexa Haeger ◽  
Arthur Coste ◽  
Cécile Lerman‐Rabrait ◽  
Julien Lagarde ◽  
Jörg B. Schulz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Magnetic Resonance ◽  
High Field ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Sodium Imaging
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