scholarly journals A pilot study on Alzheimer’s disease‐related biological and cognitive markers in dementia and history of mild traumatic brain injury

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Christian LoBue ◽  
Patricia Champagne ◽  
Catherine E Munro ◽  
Kyle B Womack ◽  
Brendan Kelley ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pilot Study ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Markers ◽  
History Of

P3-053: (-)-PHENSERINE (PHEN) AND THE PREVENTION OF PRE-PROGRAMMED CELL DEATH IN ALZHEIMER'S DISEASE (AD) AND MILD TRAUMATIC BRAIN INJURY (MTBI)

2006 ◽  
Vol 14 (7S_Part_20) ◽  
pp. P1083-P1083
Author(s):  
Daniela Lecca ◽  
Miaad Bader ◽  
David Tweedie ◽  
Debomoy K. Lahiri ◽  
Robert E. Becker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Cell Death ◽  
Brain Injury ◽  
Programmed Cell Death ◽  
Mild Traumatic Brain Injury

P1-380: MRI CLASSIFIERS CHARACTERIZE MILD TRAUMATIC BRAIN INJURY IN SYMPTOMATIC AND PRESYMPTOMATIC STAGES AND DIFFERENTIATE FROM ALZHEIMER'S DISEASE-RELATED IMPAIRMENT

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P443-P445
Author(s):  
Dawn C. Matthews ◽  
Randolph D. Andrews ◽  
Ana S. Lukic ◽  
Virendra R. Mishra ◽  
Sarah Jane Banks ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury

scholarly journals Comparing Cortical Demyelination in Geriatric Mild Traumatic Brain Injury and Alzheimer’s Disease

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 637-637
Author(s):  
Shania Wang ◽  
Nahian Chowdhury ◽  
Sean Mahoney ◽  
Andrei Irimia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Parietal Lobe ◽  
Post Injury ◽  
Temporal Lobes ◽  
Magnetic Resonance Imaging Mri ◽  
Time Changes

Abstract Mild traumatic brain injury (mTBI) accelerates the rate of age-associated brain atrophy, whose pattern resembles the cortical neurodegeneration pattern observed in Alzheimer’s disease (AD). Because the ratio R of T1-to-T2-weighted magnetic resonance imaging (MRI) intensities is a surrogate measure of cortical myelin concentration, mapping and quantifying changes in this ratio can improve our understanding of demyelination after geriatric mTBI and AD. T1- and T2-weighted MRIs were acquired acutely and ~6 months post-injury from 68 healthy controls (HCs, age (years, y): μ = 76 y, σ = 4 y), 19 mTBIs (age μ = 70 y, σ = 5 y), and 33 ADs (age μ = 77, σ = 6). Volumes were co-registered using 3D Slicer’s BRAINSFit module, and T2-constrained segmentations of T1 volumes were obtained using FreeSurfer. R and its time changes were computed at each cortical location. When comparing mTBI and AD patients to HCs, significant differences in R were found across ~10% and ~23% of the cortex, respectively (p < 0.05). When comparing mTBI to AD, the former exhibited significantly less myelin content in the lateral, medial, and ventral temporal lobes (p < 0.05), on the medial aspects of superior parietal lobules and superior frontal gyri (p < 0.05), and in orbital gyri (p < 0.05), whereas AD subjects had less myelin content on lateral aspect of the parietal lobe (p < 0.05). These results highlight demyelination differences in mTBI and AD. Future studies should examine the long-term trajectories to quantify the risk of neurodegenerative disease after mTBI.

scholarly journals A-010 Traumatic Brain Injury, APOE, and Age at Diagnosis of Alzheimer’s Disease

2020 ◽  
Vol 35 (6) ◽  
pp. 800-800
Author(s):  
Alexander C ◽  
Suhr J
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Age Of Onset ◽  
Inclusion Criteria ◽  
Health History ◽  
Health Factors ◽  
Age Of Diagnosis ◽  
History Of

Abstract Objective Traumatic brain injury (TBI) is potentially a risk factor for Alzheimer’s disease (AD). This relationship may depend on the severity of TBI as well as other risk factors including APOE. We examined whether TBI status affects age of onset of AD, while improving on prior literature’s methodological issues. Method Data from the National Alzheimer’s Coordinating Centers were used. Inclusion criteria included: normal cognition at baseline; eventual diagnosis of AD; adults aged 50 and older; at least 3 years of follow-up data. Covariates included age at baseline and history of TIA, stroke, or hypertension. The resulting sample (N = 485) was 65.2% female; 89.1% White, 9.1% Black; and 4.5% Hispanic; 8% with TBI; and 42% with APOE4. Average age at baseline was 79.2 (SD = 7.6). ANCOVAs were used to determine whether TBI status (no TBI; TBI with brief LOC; TBI with extended LOC) was associated with earlier age of diagnosis for AD, controlling for age at baseline and health factors. APOE status was added to a second ANCOVA. Results Age at baseline (p < .001), but not health history (p = .777), was related to age of AD diagnosis. TBI status was not associated with age of AD diagnosis (p = .737). When APOE and the interaction between APOE and TBI status were added to the model, neither was significant (p’s = .150, .647). Conclusions When controlling for baseline cognition, age at baseline, and health factors, there was no relationship between TBI status and age of diagnosis of AD. However, use of more stringent inclusion criteria as compared to previous studies may have reduced power significantly.

[P1-259]: PHOSPHOLIPID DISRUPTION IN THE BRAIN LINKS MOUSE MODELS OF REPETITIVE MILD TRAUMATIC BRAIN INJURY AND ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_7) ◽  
pp. P348-P349
Author(s):  
Joseph Ojo ◽  
Moustafa Algamal ◽  
Laila Abdullah ◽  
Fiona Crawford ◽  
Jim E. Evans ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Models ◽  
Mild Traumatic Brain Injury ◽  
The Brain

P1-112: Rate of decline for Alzheimer's disease patients with a history of traumatic brain injury

2015 ◽  
Vol 11 (7S_Part_8) ◽  
pp. P382-P383
Author(s):  
Yorghos Tripodis ◽  
Nikolaos Zirogiannis ◽  
Brandon E. Gavett ◽  
Christine Chaisson ◽  
Brett Martin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
History Of ◽  
Rate Of Decline
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