scholarly journals A 48‐year‐old female, with a family history of AD PSEN1 mutation, who developed mild cognitive impairment and tried ketogenic diet‐associated medium‐chain triglyceride as treatment

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Gustavo Melo de Andrade Lima ◽  
Marta Corrado ◽  
Marcela Marques de Oliveira Gregório ◽  
Paulo Henrique Ferreira Bertolucci
2019 ◽  
Vol 15 ◽  
pp. P496-P497
Author(s):  
Scott C. Neu ◽  
Judy Pa ◽  
Rebecca L. Koscik ◽  
Sterling C. Johnson ◽  
Walter A. Kukull ◽  
...  

2014 ◽  
Vol 43 (1) ◽  
pp. 143-152 ◽  
Author(s):  
Byoung Seok Ye ◽  
Juhee Chin ◽  
Seong Yoon Kim ◽  
Jung-Sun Lee ◽  
Eun-Joo Kim ◽  
...  

2020 ◽  
Author(s):  
Gabriela S Neves ◽  
Mariana S Lunardi ◽  
Katia Lin ◽  
Débora Kurrle Rieger ◽  
Letícia C Ribeiro ◽  
...  

Abstract Pharmacoresistant epilepsy causes serious deleterious effects on the patient’s health and quality of life. For this condition, a ketogenic diet (KD) is a treatment option. The KD is a general term for a set of diets that contain high amounts of fat and low content of carbohydrates. The most prominent KD treatments are classical KD (4:1 ratio of fat to carbohydrate), modified Atkins diet (2:1 to 1:1 ratio), medium-chain triglycerides KD (with medium-chain triglyceride as a part of the fat content), and low glycemic index KD (using low glycemic carbohydrates). KD has been widely prescribed for children with epilepsy but not for adult patients. One of the main concerns about adult use of KD is its cardiovascular risk associated with high-fat and cholesterol intake. Therefore, this narrative review provides comprehensive information of the current literature on the effects of KD on lipid profile, glycemic-control biomarkers, and other cardiometabolic risk factors in adult patients with pharmacoresistant epilepsy.


Author(s):  
A.J. Sinclair ◽  
B. Vellas

The recent addition of the Diabetes and Cognitive Decline section to JPAD marks a milestone in the history of this progressive journal as it recognises the important contribution that Diabetes makes to the aetiology of both vascular and neurodegenerative dementia syndromes (1-3). It has been observed that diabetes in the presence of hypertension leads to a more pronounced cognitive decline (4) and that at an early stage of cognitive decline (mild cognitive impairment ( MCI)), diabetes accelerates the progression of MCI to dementia (5).


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