scholarly journals Depressive symptoms modeled across the life‐course are associated with higher risk of dementia and cognitive decline: A pooled cohort analysis

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Willa D Brenowitz ◽  
Adina Zeki Al Hazzouri ◽  
Eric Vittinghoff ◽  
Karen A Matthews ◽  
Sherita H Golden ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Course ◽  
Cognitive Decline ◽  
Cohort Analysis ◽  
The Life Course

Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline

2021 ◽  
pp. 1-11
Author(s):  
Willa D. Brenowitz ◽  
Adina Zeki Al Hazzouri ◽  
Eric Vittinghoff ◽  
Sherita H. Golden ◽  
Annette L. Fitzpatrick ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Life Course ◽  
Cognitive Decline ◽  
Early Adulthood ◽  
Adult Life ◽  
Late Life ◽  
Cognitive Outcomes ◽  
Life Stages ◽  
The Life Course

Background: Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and decline. Methods: Using a pooled study of 4 prospective cohorts (ages 20–89), we imputed adult life course depressive symptoms trajectories based on Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and calculated time-weighted averages for early adulthood (ages 20–49), mid-life (ages 50–69), and late-life (ages 70–89) for 6,122 older participants. Adjusted pooled logistic and mixed-effects models estimated associations of imputed depressive symptoms with two cognitive outcomes: cognitive impairment defined by established criteria and a composite cognitive score. Results: In separate models, elevated depressive symptoms in each life stage were associated with cognitive outcomes: early adulthood OR for cognitive impairment = 1.59 (95%CI: 1.35,1.87); mid-life OR = 1.94 (95%CI:1.16, 3.26); and late-life OR = 1.77 (95%CI:1.42, 2.21). When adjusted for depressive symptoms in the other life-stages, elevated depressive symptoms in early adulthood (OR = 1.73; 95%CI: 1.42,2.11) and late-life (OR = 1.43; 95%CI: 1.08,1.89) remained associated with cognitive impairment and were also associated with faster rates of cognitive decline (p <  0.05). Conclusion: Imputing depressive symptom trajectories from pooled cohorts may help expand data across the life course. Our findings suggest early adulthood depressive symptoms may be a risk factor for cognitive impairment independent of mid- or late-life depressive symptoms.

scholarly journals Trajectories of Unsecured Debt across the Life Course and Mental Health at Midlife

2018 ◽  
Vol 10 (1) ◽  
pp. 61-79 ◽  
Author(s):  
Amy Ruining Sun ◽  
Jason N. Houle
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Life Course ◽  
Debt Accumulation ◽  
Unsecured Debt ◽  
Trajectory Models ◽  
Low Levels ◽  
Using Data ◽  
The Life Course ◽  
Substantial Heterogeneity

In this paper, we contribute to a growing literature on debt and mental health and ask whether patterns of unsecured debt accumulation and repayment over two decades are associated with depressive symptoms at age 50. Using data from the National Longitudinal Study of Youth 1979 Cohort and group trajectory models, we have three key findings. First, we find substantial heterogeneity in debt trajectories across the life course. Second, respondents who report consistently high debt levels across the life course or who cycle in and out of high debt report significantly more depressive symptoms than respondents who hold consistently low levels of debt. These findings hold for both absolute and relative (debt-to-income) debt. Third, we find that the association between debt and depressive symptoms is strongest among respondents with less than a college degree, but we find less evidence for heterogeneity by race in this cohort.

scholarly journals CONTINUITY OF CAREER OVER THE LIFE COURSE ON LIFE SATISFACTION AND DEPRESSIVE SYMPTOMS IN LATER LIFE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S128-S129
Author(s):  
Melanie S Hill ◽  
James E Hill ◽  
Stephanie Richardson ◽  
Jessica Brown ◽  
Jeremy B Yorgason ◽  
...  
Keyword(s):  
High School ◽  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Life Course ◽  
Career Choice ◽  
Early Adulthood ◽  
Later Life ◽  
Well Being ◽  
The Life Course ◽  
The Impact

Abstract Identity scholars have suggested that having a unified sense of past, present, and future is related to positive well-being outcomes (Whitbourne, Sneed & Skultety, 2009). One’s occupation can have a profound influence on an individual’s identity throughout the life course (Nazar & van der Heijden, 2012). Research has looked at career mobility among younger age groups (Baiyun, Ramkissoon, Greenwood, & Hoyte, 2018); however, less is known about the impact of career stability later in life. Consistency in career choice over the life course may have positive outcomes down the line as career becomes part of an individual's identity. The current study uses the Life and Family Legacies dataset, a longitudinal state-representative sample of 3,348, to examine individual’s careers at three points in the life course: high school (projected career choice), early adulthood, and later life. Results revealed that a match of desired career in high school and actual career in early adulthood was not predictive of life satisfaction or depressive symptoms in later life. However, a match of career in early adulthood and later life was significantly related to better life satisfaction and less depressive symptoms, which was explained through higher levels of job satisfaction. This study highlights the importance of acquiring and maintaining a career that is fulfilling to the individual over the course of early adulthood to later life.

Optimizing cognitive development over the life course and preventing cognitive decline: Introducing the Cognitive Health Environment Life Course Model (CHELM)

2013 ◽  
Vol 38 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Kaarin J. Anstey
Keyword(s):  
Cognitive Function ◽  
Cognitive Development ◽  
Life Course ◽  
Cognitive Decline ◽  
Adult Life ◽  
Cognitive Domain ◽  
Cognitive Health ◽  
Differential Development ◽  
Theoretical Perspectives ◽  
The Life Course

Optimal cognitive development is defined in this article as the highest level of cognitive function reached in each cognitive domain given a person’s biological and genetic disposition, and the highest possible maintenance of cognitive function over the adult life course. Theoretical perspectives underpinning the development of a framework for understanding optimal cognitive development are described, including differential development, intra-individual dynamics, cascades, biological mechanisms, reserve capacity, and plasticity. The Cognitive Health and Environment Life Course Model (CHELM) is proposed as a means to provide a framework for understanding the socio-demographic, lifestyle, and health factors influencing cognitive development and decline. The CHELM may guide framing of policy and interventions to optimize cognitive development and minimize cognitive decline in late-life.

Sign in / Sign up

Export Citation Format

Share Document