Urinary leukotriene E4 is a biomarker for chronic rhinosinusitis associated with leukotriene dysregulation irrespective of aspirin sensitivity status

2021 ◽  
Author(s):  
Beau M. Idler ◽  
Devyani Lal ◽  
Michael J. Marino
Keyword(s):  
Chronic Rhinosinusitis ◽  
Aspirin Sensitivity

scholarly journals Aspirin Sensitivity and Chronic Rhinosinusitis with Polyps: A Fatal Combination

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Hendrik Graefe ◽  
Christina Roebke ◽  
Dirk Schäfer ◽  
Jens Eduard Meyer
Keyword(s):  
Chronic Rhinosinusitis ◽  
Respiratory Disease ◽  
Clinical Features ◽  
Nasal Polyposis ◽  
Molecular Mechanisms ◽  
Molecular Pathogenesis ◽  
Surgical Interventions ◽  
Aspirin Sensitivity ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Lower Airways

Aspirin-exacerbated respiratory disease (AERD) refers to aspirin sensitivity, chronic rhinosinusitis (CRS), nasal polyposis, asthma, eosinophil inflammation in the upper and lower airways, urticaria, angioedema, and anaphylaxis following the ingestion of NSAIDs. Epidemiologic and pathophysiological links between these diseases are established. The precise pathogenesis remains less defined, even though there is some progress in the understanding of several molecular mechanisms. Nevertheless, these combinations of diseases in patients classified by AERD constitute a fatal combination and may be difficult to treat with standard medical and surgical interventions. This paper reviews in brief the epidemiology, clinical features, diagnosis, molecular pathogenesis, and specific therapies of patients classified by AERD and postulates future attempts to gain new insights into this disease.

scholarly journals Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity

2014 ◽  
Vol 133 (6) ◽  
pp. 1759-1763 ◽  
Author(s):  
Mahboobeh Mahdavinia ◽  
Roderick G. Carter ◽  
Christopher J. Ocampo ◽  
Whitney Stevens ◽  
Atsushi Kato ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Aspirin Sensitivity

Nasal epithelia cultures of patients with chronic rhinosinusitis show altered ion transport capacities

Pneumologie ◽  
2016 ◽  
Vol 70 (07) ◽  
Author(s):  
JJ Salomon ◽  
T Albrecht ◽  
H Scheuermann ◽  
I Baumann ◽  
MA Mall
Keyword(s):  
Ion Transport ◽  
Chronic Rhinosinusitis
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