Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors

2020 ◽  
Author(s):  
Jie Deng ◽  
Li Hui Tan ◽  
Michael A. Kohanski ◽  
David W. Kennedy ◽  
John V. Bosso ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Cholinergic Receptors ◽  
Nerve Endings ◽  
Solitary Chemosensory Cells

Transcorneal stimulation of trigeminal nerve afferents to increase cerebral blood flow in rats with cerebral vasospasm: a noninvasive method to activate the trigeminovascular reflex

2002 ◽  
Vol 97 (5) ◽  
pp. 1179-1183 ◽  
Author(s):  
Basar Atalay ◽  
Hayrunnisa Bolay ◽  
Turgay Dalkara ◽  
Figen Soylemezoglu ◽  
Kamil Oge ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Vasospasm ◽  
Trigeminal Nerve ◽  
Nerve Endings ◽  
Noninvasive Method ◽  
Direct Stimulation ◽  
Content Type ◽  
Fine Print ◽  
Stimulation Of

Object. The goal of this study was to investigate whether stimulation of trigeminal afferents in the cornea could enhance cerebral blood flow (CBF) in rats after they have been subjected to experimental subarachnoid hemorrhage (SAH). Cerebral vasospasm following SAH may compromise CBF and increase the risks of morbidity and mortality. Currently, there is no effective treatment for SAH-induced vasospasm. Direct stimulation of the trigeminal nerve has been shown to dilate constricted cerebral arteries after SAH; however, a noninvasive method to activate this nerve would be preferable for human applications. The authors hypothesized that stimulation of free nerve endings of trigeminal sensory fibers in the face might be as effective as direct stimulation of the trigeminal nerve. Methods. Autologous blood obtained from the tail artery was injected into the cisterna magna of 10 rats. Forty-eight and 96 hours later (five rats each) trigeminal afferents were stimulated selectively by applying transcorneal biphasic pulses (1 msec, 3 mA, and 30 Hz), and CBF enhancements were detected using laser Doppler flowmetry in the territory of the middle cerebral artery. Stimulation-induced changes in cerebrovascular parameters were compared with similar parameters in sham-operated controls (six rats). Development of vasospasm was histologically verified in every rat with SAH. Corneal stimulation caused an increase in CBF and blood pressure and a net decrease in cerebrovascular resistance. There were no significant differences between groups for these changes. Conclusions. Data from the present study demonstrate that transcorneal stimulation of trigeminal nerve endings induces vasodilation and a robust increase in CBF. The vasodilatory response of cerebral vessels to trigeminal activation is retained after SAH-induced vasospasm.

Trigeminal nerve endings of lingual mucosa and musculature of the rat

1992 ◽  
Vol 586 (1) ◽  
pp. 162-165 ◽  
Author(s):  
Setsuko Suemune ◽  
Toshikazu Nishimori ◽  
Mitsuteru Hosoi ◽  
Yoshitaka Suzuki ◽  
Hiromichi Tsuru ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Nerve Endings ◽  
Lingual Mucosa

Decreased entry of calcium into motor nerve endings upon activation of presynaptic cholinergic receptors

2012 ◽  
Vol 446 (1) ◽  
pp. 283-285 ◽  
Author(s):  
E. F. Khaziev ◽  
N. F. Fatikhov ◽  
D. V. Samigullin ◽  
G. L. Barrett ◽  
E. A. Bukharaeva ◽  
...  
Keyword(s):  
Motor Nerve ◽  
Cholinergic Receptors ◽  
Nerve Endings
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