Specific sublingual immunotherapy in children with perennial rhinitis: a systemic review and meta‐analysis

2020 ◽  
Vol 10 (11) ◽  
pp. 1226-1235
Author(s):  
Liang Chen ◽  
Lijuan Lei ◽  
Yinghuang Cai ◽  
Tianlin Li
2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Takashi Fujimura ◽  
Yoshitaka Okamoto ◽  
Masaru Taniguchi

Immunotherapy is considered to be the only curative treatment for allergic diseases such as pollinosis, perennial rhinitis, asthma, and food allergy. The sublingual route is widely applied for immunotherapy for allergy, instead of the conventional administration by subcutaneous route. A recent meta-analysis of sublingual immunotherapy (SLIT) has shown that this approach is safe, has positive clinical effects, and provides prolonged therapeutic effects after discontinuation of treatment. However, the mechanism of SLIT and associated biomarkers are not fully understood. Biomarkers that change after or during SLIT have been reported and may be useful for response monitoring or as prognostic indicators for SLIT. In this review, we focus on the safety, therapeutic effects, including prolonged effects after treatment, and new methods of SLIT. We also discuss response monitoring and prognostic biomarkers for SLIT. Finally, we discuss immunological mechanisms of SLIT with a focus on oral dendritic cells and facilitated antigen presentation.


2017 ◽  
Vol 23 ◽  
pp. 125-126
Author(s):  
Olubukola Ajala ◽  
Freda Mold ◽  
Charlotte Broughton ◽  
Debbie Cooke ◽  
Martin Whyte

2020 ◽  
Vol 21 (10) ◽  
pp. 790-801 ◽  
Author(s):  
Narut Prasitlumkum ◽  
Wasawat Vutthikraivit ◽  
Sittinun Thangjui ◽  
Thiratest Leesutipornchai ◽  
Jakrin Kewcharoen ◽  
...  

2017 ◽  
Vol 4 (2) ◽  
pp. 93-96 ◽  
Author(s):  
A. Vishnuvardhan Reddy ◽  
◽  
Syed Ali Aasim ◽  
Rajendra Prasad ◽  
Karthik Satya ◽  
...  

Heliyon ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. e06972
Author(s):  
Haileyesus Gedamu ◽  
Teshager W/giorgis ◽  
Getasew Tesfa ◽  
Yilkal Tafere ◽  
Minichil Genet

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