Aspirin desensitization therapy in aspirin‐exacerbated respiratory disease: a systematic review

2020 ◽  
Vol 10 (4) ◽  
pp. 450-464 ◽  
Author(s):  
Natasha Larivée ◽  
Christopher J. Chin
Keyword(s):  
Systematic Review ◽  
Respiratory Disease ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Desensitization Therapy

Benefits and harms of aspirin desensitization for aspirin‐exacerbated respiratory disease: a systematic review and meta‐analysis

2019 ◽  
Vol 9 (12) ◽  
pp. 1409-1419 ◽  
Author(s):  
Derek K. Chu ◽  
Daniel J. Lee ◽  
Keith M. Lee ◽  
Holger J. Schünemann ◽  
Wojciech Szczeklik ◽  
...  
Keyword(s):  
Systematic Review ◽  
Respiratory Disease ◽  
Meta Analysis ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease

Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease

2020 ◽  
pp. 019459982093213
Author(s):  
Mohamad R. Chaaban ◽  
David Moffatt ◽  
Alex E. Wright ◽  
James A. Cowthran ◽  
En Shuo Hsu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Respiratory Disease ◽  
Meta Analysis ◽  
Forced Expiratory Volume ◽  
Life Assessment ◽  
Steroid Use ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease

Objective The objective of this study is to explore the sinopulmonary outcomes of aspirin desensitization through a systematic review and meta-analysis. Data Sources Embase and OVID Medline databases. Review Methods A systematic review of published articles on outcomes following aspirin desensitization in any language for relevant articles was performed in February 2019. Outcomes included sinonasal quality-of-life assessment, sense-of-smell scores, FEV-1 (forced expiratory volume in 1 second), and medication/steroid use. Results Thirteen studies met the inclusion criteria out of 6055 articles screened. Aspirin desensitization resulted in significant improvement in FEV-1 and reduction in asthma medication/steroid use ( P < .05). There was no significant improvement in the sinonasal quality of life of patients who underwent aspirin desensitization ( P = .098). Conclusion Aspirin desensitization appears to be effective in improving pulmonary outcomes and should be considered in the treatment of patients with aspirin-exacerbated respiratory disease. However, good-quality studies are still needed to determine the ideal protocol tailored to individual patients.

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