scholarly journals Central compartment involvement in aspirin‐exacerbated respiratory disease: the role of allergy and previous sinus surgery

2019 ◽  
Vol 9 (9) ◽  
pp. 1017-1022 ◽  
Author(s):  
John M. DelGaudio ◽  
Joshua M. Levy ◽  
Sarah K. Wise
Keyword(s):  
Respiratory Disease ◽  
Central Compartment ◽  
Sinus Surgery ◽  
Aspirin Exacerbated Respiratory Disease

scholarly journals The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD)

2016 ◽  
Vol 82 (3) ◽  
pp. 263-268 ◽  
Author(s):  
Jonas Willian Spies ◽  
Fabiana Cardoso Pereira Valera ◽  
Daniel Loiola Cordeiro ◽  
Taís Nociti de Mendonça ◽  
Marcelo Gonçalves Junqueira Leite ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease

scholarly journals Aspirin and salicylate in respiratory disease

2013 ◽  
Vol 51 (3) ◽  
pp. 195-205
Author(s):  
J.E. Mitchell ◽  
I. Skypala
Keyword(s):  
Salicylic Acid ◽  
Natural History ◽  
Respiratory Disease ◽  
Evidence Base ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Oral Aspirin

This article describes the natural history, pathogenesis and diagnosis of Aspirin Exacerbated Respiratory Disease. The evidence base for the role of oral aspirin and nasal L-Lysine-aspirin desensitisation is reviewed. Evidence for the role of dietary salicylic acid and its avoidance is also reviewed.

scholarly journals Effectiveness of endoscopic sinus surgery and aspirin therapy in the management of aspirin-exacerbated respiratory disease

2021 ◽  
Vol 42 (2) ◽  
pp. 136-141
Author(s):  
Auddie M. Sweis ◽  
Tran B. Locke ◽  
Kevin I. Ig-Izevbekhai ◽  
Theodore C. Lin ◽  
Ankur Kumar ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Endoscopic Sinus Surgery ◽  
Test Score ◽  
Aspirin Therapy ◽  
Sinus Surgery ◽  
Secondary Outcome ◽  
Persistent Symptoms ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Patient Reported ◽  
The Mean

Background: Aspirin therapy and/or type 2 (T2) biologics are used in the management of aspirin-exacerbated respiratory disease (AERD). Objective: To identify the number of patients with AERD who tolerated aspirin therapy, yet due to persistent symptoms, incorporated T2 biologic management. Methods: A retrospective review was performed between July 2016 and June 2019. Patients with AERD and who underwent endoscopic sinus surgery (ESS), aspirin desensitization (AD), and at least 6 months of aspirin therapy (ATAD) after AD, and who remained biologic-naive up through this timepoint were included in the study. Introduction of a T2 biologic while on ATAD was the primary outcome. The secondary outcome was a change in a validated patient-reported outcome measure for chronic rhinosinusitis score between the postoperative predesensitization timepoint, and the 6-month postdesensitization timepoint, presented as means and compared by using the Student's t-test. Results: A total of 103 patients met inclusion criteria. Two patients (1.9%) ultimately supplemented ATAD with a T2 biologic. The mean outcomes measure test score after 6 months of ATAD for patients who received biologics was 40.5 versus 15 in those who did not receive biologics (p = 0.02). The mean differences between the postoperative predesensitization test score and the 6-month postdesensitization test score for patients who went on to receive biologics was an increase of 13 versus a decrease of 10 for those patients who did not receive biologics (p = 0.12). Conclusion: ESS, coupled with AD and ATAD, was successful in the long-term management of the majority of the patients with AERD, which rarely required the incorporation of T2 biologics. Patient questionnaires, such as outcomes measure test score, may identify aspirin therapy failures and help guide the practitioner in deciding when to introduce T2 biologics into the patient's treatment regimen.

Investigating the role of smoking in the development of aspirin-exacerbated respiratory disease

2018 ◽  
Author(s):  
Hiroaki Hayashi ◽  
Yuma Fukutomi ◽  
Chihiro Mitsui ◽  
Kentaro Watai ◽  
Maki Iwata ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Aspirin Exacerbated Respiratory Disease

Allergic Rhinitis and Aspirin-Exacerbated Respiratory Disease as Predictors of the Olfactory Outcome after Endoscopic Sinus Surgery

2009 ◽  
Vol 23 (3) ◽  
pp. 348-353 ◽  
Author(s):  
Michael Katotomichelakis ◽  
Maria Riga ◽  
Spyridon Davris ◽  
Gregorios Tripsianis ◽  
Maria Simopoulou ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Respiratory Disease ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Olfactory Acuity ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Negative Effect ◽  
Time Frames

Background Unlike the functional outcomes of endoscopic sinus surgery, which have been thoroughly studied, the effect of the surgery on olfactory performance and the relative predictive factors have not been adequately assessed by literature. Allergic rhinitis and aspirin-exacerbated respiratory disease (AERD) are examined as potential confounding factors of the olfactory outcome in patients with extensive nasal polyposis and rhinosinusitis treated with functional endoscopic sinus surgery (FESS). Methods A population of 116 adults with severe nasal polyposis was subjected to FESS after failure of the appropriate medical treatment. The olfactory outcome was quantified by Sniffin’ Sticks at the 1st, 3rd, and 6th postoperative month in relation to the concomitant presence of allergic rhinitis (n = 62) or AERD (n = 18). Results Allergic patients seemed to perform worse than nonallergic patients at all time frames. However, when patients with similar olfactory acuity, age, and medical history are compared, allergic rhinitis does not seem to affect the postoperative improvement of the composite threshold-discrimination-identification scores. The same seems to apply for the likelihood of acquiring normosmia after surgery. On the contrary, AERD significantly limits the recovery of olfactory function at all follow-up examinations and patients with AERD are unlikely to become normosmic. Conclusion The olfactory recovery after FESS for nasal polyposis is significantly affected by the concomitant presence of AERD. Although allergy seems to have a general negative effect on olfactory acuity, it was not found to affect the extent of the olfactory improvement, when patients with comparable preoperative characteristics are addressed.

Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin-exacerbated respiratory disease

2017 ◽  
Vol 8 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Nithin D. Adappa ◽  
Viran J. Ranasinghe ◽  
Michal Trope ◽  
Steven G. Brooks ◽  
Jordan T. Glicksman ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Aspirin Desensitization ◽  
Aspirin Exacerbated Respiratory Disease
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