Increased expression of TIPE2 in alternatively activated macrophages is associated with eosinophilic inflammation and disease severity in chronic rhinosinusitis with nasal polyps

2017 ◽  
Vol 7 (10) ◽  
pp. 963-972 ◽  
Author(s):  
Yin Yao ◽  
Zhi-Chao Wang ◽  
Jin-Xin Liu ◽  
Jin Ma ◽  
Cai-Ling Chen ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Disease Severity ◽  
Nasal Polyps ◽  
Activated Macrophages ◽  
Eosinophilic Inflammation ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis

Allergy ◽  
2010 ◽  
Vol 66 (3) ◽  
pp. 396-403 ◽  
Author(s):  
O. Krysko ◽  
G. Holtappels ◽  
N. Zhang ◽  
M. Kubica ◽  
K. Deswarte ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated

scholarly journals Alternatively Activated Macrophages Are the Primary Retinoic Acid-Producing Cells in Human Decidua

2020 ◽  
Vol 27 (1) ◽  
pp. 334-341 ◽  
Author(s):  
Augustine Rajakumar ◽  
Maureen A. Kane ◽  
Jianshi Yu ◽  
Jace W. Jones ◽  
Hongyan Qu ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Human Decidua ◽  
Alternatively Activated

scholarly journals JAK2 Phosphorylation Signals and Their Associated Cytokines Involved in Chronic Rhinosinusitis with Nasal Polyps and Correlated with Disease Severity

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1059
Author(s):  
Yu-Tsai Lin ◽  
Wei-Chih Chen ◽  
Ming-Hsien Tsai ◽  
Jing-Ying Chen ◽  
Chih-Yen Chien ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Disease Severity ◽  
Nasal Polyps ◽  
Inflammatory Diseases ◽  
Janus Kinase ◽  
Sinus Surgery ◽  
Control Group ◽  
Jak2 Inhibitor ◽  
Ifn Γ ◽  
Snot 22

Janus kinase 2 (JAK2) is a member of the JAK family that transduces cytokine-mediated signals via the JAKs/STATs (signal transducer and activator of transcription proteins) pathway, which plays an important role in many inflammatory diseases. This study investigates the association of p-JAK2 and JAK2-associated cytokines from nasal polyp (NP) tissue with disease severity, and evaluates the p-JAK2-mediated STATs in chronic rhinosinusitis (CRS) with NP. Sixty-one CRSwNP patients with nasal polyps undergoing endoscopic sinus surgery were enrolled, while the turbinate tissues from 26 nasal obstruction patients were examined as the control group. Elevated levels of p-JAK2 were detected in CRSwNP, and significantly correlated with scores of disease severity (LMK-CT, TPS, and SNOT-22). Expressions of the JAK2-associated cytokines, such as IL-5, IL-6, IL-13, G-CSF, and IFN-γ were significantly higher in CRSwNP than in the controls, while the levels of IL-5, IL-6, IL-13, or G-CSF had positive correlation with scores of disease severity. Moreover, markedly increased expression of p-STAT3 in CRSwNP was observed relative to the control. Taken together, these data showed that the JAK2-associated cytokines including IL-6 and G-CSF may stimulate JAK2 phosphorylation to activate p-STAT3, indicating an association with disease severity and supporting its development of JAK2 inhibitor as a potential therapeutic agent for CRS.

Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages

2012 ◽  
Vol 130 (3) ◽  
pp. 743-750.e8 ◽  
Author(s):  
Natalie E. Nieuwenhuizen ◽  
Frank Kirstein ◽  
Jaisubash Jayakumar ◽  
Babele Emedi ◽  
Ramona Hurdayal ◽  
...  
Keyword(s):  
Airway Disease ◽  
Allergic Airway Disease ◽  
Activated Macrophages ◽  
Alternatively Activated Macrophages ◽  
Alternatively Activated
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