scholarly journals Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis

2017 ◽  
Vol 7 (8) ◽  
pp. 821-826 ◽  
Author(s):  
Joshua M. Levy ◽  
Jess C. Mace ◽  
Todd E. Bodner ◽  
Jeremiah A. Alt ◽  
Timothy L. Smith
Keyword(s):  
Surgical Treatment ◽  
Chronic Rhinosinusitis ◽  
Minimal Clinically Important Difference ◽  
Clinically Important Difference

scholarly journals Defining Minimal Clinically Important Difference After Open Hip Abductor Repair

2021 ◽  
Vol 9 (4) ◽  
pp. 232596712110077
Author(s):  
Tyler J. Uppstrom ◽  
Spencer W. Sullivan ◽  
Joost A. Burger ◽  
Anil S. Ranawat ◽  
Bryan T. Kelly ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Outcome Measures ◽  
Minimal Clinically Important Difference ◽  
Open Repair ◽  
Gluteus Medius ◽  
Patient Characteristics ◽  
Harris Hip Score ◽  
Younger Patients ◽  
Clinically Important Difference ◽  
Hip Abductor

Background: Open repair for gluteus medius and minimus tears is a common surgical treatment for patients with lateral hip pain associated with abductor tears; however, clinically meaningful outcomes have not been described after open surgical treatment. Purpose: To define the minimal clinically important difference (MCID) in patient-reported outcome measures (PROMs) in patients undergoing open gluteus medius or minimus repair, and to identify preoperative patient characteristics predictive of achieving MCID postoperatively. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review of prospectively collected data from a consecutive series of patients undergoing open abductor repair between July 2010 and April 2019 was conducted. Perioperative patient data collected included patient characteristics and preoperative and postoperative modified Harris Hip Score (mHHS) and International Hip Outcome Tool (iHOT-33) score. Paired t tests were utilized to compare preoperative and postoperative PROMs and MCID was calculated for both PROMs. Multivariate logistical regression analysis was used to assess the association between preoperative variables and the likelihood for achieving MCID. Results: A total of 47 patients were included in the study. The majority of patients were female (78.7%), with an average age of 63 ± 10.7 years. The average follow-up for both the mHHS and the iHOT-33 surveys was 37.8 ± 27.9 months (range, 10-102 months). Patients demonstrated statistically significant improvements on the mHHS and iHOT-33 postoperatively ( P < .001 for both). The MCIDs of mHHS and iHOT-33 were calculated to be 9.9 and 14.3, respectively. Overall, 82.9% of patients achieved MCID for mHHS and 84.1% of patients achieved MCID for iHOT-33 postoperatively. Multivariate logistical analysis demonstrated younger patients were less likely to achieve MCID for both outcome measures. Four patients (8.5%) suffered postoperative complications after open repair. Conclusion: This study defined MCID for mHHS and iHOT-33 for patients undergoing open repair of hip abductor tears, with a large percentage of patients (>80%) achieving meaningful outcomes for both outcome measures. There was a low complication rate. Younger patients were less likely to achieve MCID compared with older patients.

scholarly journals Responsiveness and minimal clinically important difference for the EQ-5D in chronic rhinosinusitis

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0 ◽  
Author(s):  
L.P. Hoehle ◽  
K.M. Phillips ◽  
M.M. Speth ◽  
D.S. Caradonna ◽  
S.T. Gray ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Minimal Clinically Important Difference ◽  
Clinically Important Difference

scholarly journals Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis

2017 ◽  
Vol 7 (12) ◽  
pp. 1149-1155 ◽  
Author(s):  
Naweed I. Chowdhury ◽  
Jess C. Mace ◽  
Todd E. Bodner ◽  
Jeremiah A. Alt ◽  
Adam S. Deconde ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Minimal Clinically Important Difference ◽  
Clinically Important Difference ◽  
Symptom Domains ◽  
Snot 22

Multi-institutional minimal clinically important difference of the 22-item Sinonasal Outcome Test in medically managed chronic rhinosinusitis

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
K.M. Phillips ◽  
F.A. Houssein ◽  
L.M. Boeckermann ◽  
K.W. Singerman ◽  
D.T. Liu ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Chronic Rhinosinusitis ◽  
General Health ◽  
Nasal Polyps ◽  
Minimal Clinically Important Difference ◽  
Medical Treatments ◽  
Clinically Important Difference ◽  
Sinonasal Outcome Test ◽  
Snot 22

Background: With a rapid proliferation of clinical trials to study novel medical treatments for CRS, the objective of this study was to study the minimal clinically important difference (MCID) of the 22-item Sinonasal Outcome Test (SNOT-22) in medically-managed CRS patients. Methods: A total of 183 medically-treated CRS patients were recruited. All patients completed a SNOT-22 at enrollment and subsequent follow up visit. Distribution and anchor-based methods were used for MCID calculation. These data were combined with data from a previously published study on SNOT-22 MCID in 247 medically managed CRS patients to determine a final recommended MCID value using the combined cohort of 430 patients. Results: In our cohort, distribution- and anchor-based methods—using both sinus-specific and general health anchors—provided greatest support for a 12-point SNOT-22 MCID, which had approximately 55% sensitivity but 81% specificity for detecting patients explicitly reporting improvement in their sinus symptoms and general health. In the combined cohort of 430 patients, we also found greatest support for a 12-point SNOT-22 MCID, which had approximately 57% sensitivity and 81% specificity for detecting patients explicitly reporting improvement in their sinus symptoms and general health. We also find evidence that the MCID value may be higher in CRS patients without nasal polyps compared to those with nasal polyps. Conclusions: Our results - which include data from patients from two different institutions and regions - confirm a SNOT-22 MCID of 12 in medically managed CRS patients. The SNOT-22 MCID was specific but not sensitive for identifying CRS patients experiencing improvement in symptoms or general health.

Minimal clinically important difference for the 22-item Sinonasal Outcome Test in medically managed patients with chronic rhinosinusitis

2018 ◽  
Vol 43 (5) ◽  
pp. 1328-1334 ◽  
Author(s):  
Katie M. Phillips ◽  
Lloyd P. Hoehle ◽  
David S. Caradonna ◽  
Stacey T. Gray ◽  
Ahmad R. Sedaghat
Keyword(s):  
Chronic Rhinosinusitis ◽  
Minimal Clinically Important Difference ◽  
Clinically Important Difference ◽  
Sinonasal Outcome Test

Long-term functional outcome of surgical treatment for degenerative cervical myelopathy

2021 ◽  
pp. 1-11
Author(s):  
Mark D. Dijkman ◽  
Martine W. T. van Bilsen ◽  
Michael G. Fehlings ◽  
Ronald H. M. A. Bartels
Keyword(s):  
Surgical Treatment ◽  
Functional Outcome ◽  
Cervical Myelopathy ◽  
Minimal Clinically Important Difference ◽  
Clinically Important Difference ◽  
Surgical Data ◽  
The Mean ◽  
Degenerative Cervical Myelopathy

OBJECTIVE Degenerative cervical myelopathy (DCM) is a major global cause of spinal cord dysfunction. Surgical treatment is considered a safe and effective way to improve functional outcome, although information about long-term functional outcome remains scarce despite increasing longevity. The objective of this study was to describe functional outcome 10 years after surgery for DCM. METHODS A prospective observational cohort study was undertaken in a university-affiliated neurosurgery department. All patients who underwent surgery for DCM between 2008 and 2010 as part of the multicenter Cervical Spondylotic Myelopathy International trial were included. Participants were approached for additional virtual assessment 10 years after surgery. Functional outcome was assessed according to the modified Japanese Orthopaedic Association (mJOA; scores 0–18) score at baseline and 1, 2, and 10 years after surgery. The minimal clinically important difference was defined as 1-, 2-, or 3-point improvement for mild, moderate, and severe myelopathy, respectively. Outcome was considered durable when stabilization or improvement after 2 years was maintained at 10 years. Self-evaluated effect of surgery was assessed using a 4-point Likert-like scale. Demographic, clinical, and surgical data were compared between groups that worsened and improved or remained stable using descriptive statistics. Functional outcome was compared between various time points during follow-up with linear mixed models. RESULTS Of the 42 originally included patients, 37 participated at follow-up (11.9% loss to follow-up, 100% response rate). The mean patient age was 56.1 years, and 42.9% of patients were female. Surgical approaches were anterior (76.2%), posterior (21.4%), or posterior with fusion (2.4%). The mean follow-up was 10.8 years (range 10–12 years). The mean mJOA score increased significantly from 13.1 (SD 2.3) at baseline to 14.2 (SD 3.3) at 10 years (p = 0.01). A minimal clinically important difference was achieved in 54.1%, and stabilization of functional status was maintained in 75.0% in the long term. Patients who worsened were older (median 63 vs 52 years, p < 0.01) and had more comorbidities (70.0% vs 25.9%, p < 0.01). A beneficial effect of surgery was self-reported by 78.3% of patients. CONCLUSIONS Surgical treatment for DCM results in satisfactory improvement of functional outcome that is maintained at 10-year follow-up.

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