Nonadherence to sublingual immunotherapy in allergic rhinitis: a real-life analysis

Aim: Clinical efficacy of sublingual immunotherapy for grass pollen-induced allergic rhinitis (AR) needs to translate into patient benefit. Patients & methods: Patients received Oralair (Stallergenes, Antony, France) in real-life medical practice. Patient-relevant treatment benefits were measured with the AR-specific Patient Benefit Index. Subgroups were analyzed regarding distinct patient characteristics. Results: Data of 883 patients (children, adolescents, and adults) were analyzed. The highest-ranked patient needs referred to having less AR-symptoms, being able to go outdoors, and being free in the choice of leisure activities. Most patients (89.2–94.6%) attained at least minimally relevant benefit. All subgroups reported relevant benefits, with significantly higher scores in some subgroups. Conclusion: Treatment with Oralair was associated with considerable patient-relevant benefit in all age groups.

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A real-life, long-term, retrospective analysis evidencing slower progression of grass pollen allergic rhinitis in patients treated with sublingual immunotherapy tablets

10.26226/morressier.5ae1c313d462b8029238d883 ◽

2018 ◽

Author(s):

Philippe Devillier

Keyword(s):

Allergic Rhinitis ◽

Retrospective Analysis ◽

Grass Pollen ◽

Sublingual Immunotherapy ◽

Real Life

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A Three-Year Course of House Dust Mite Sublingual Immunotherapy Appears Effective in Controlling the Symptoms of Allergic Rhinitis

American Journal of Rhinology and Allergy ◽

10.1177/1945892418764966 ◽

2018 ◽

Vol 32 (3) ◽

pp. 147-152 ◽

Cited By ~ 1

Author(s):

Silviya M. Novakova ◽

Plamena I. Novakova ◽

Plamen H. Yakovliev ◽

Maria T. Staevska ◽

Nonka G. Mateva ◽

...

Keyword(s):

Allergic Rhinitis ◽

Visual Analog Scale ◽

House Dust ◽

House Dust Mite ◽

Sublingual Immunotherapy ◽

Real Life ◽

Analog Scale ◽

Strong Negative Correlation ◽

Life Study ◽

Dust Mite

Background Allergic rhinitis is the most common allergic disorder. Although the management of the disease is successful in many patients, based on guidelines, some of them remain with symptoms uncontrolled with pharmacotherapy. Presently, there is no substantiated information on the control of allergic rhinitis in patients who underwent sublingual immunotherapy. Objective The purpose of this prospective follow-up study was to assess the control of allergic rhinitis in adults after a three-year course of house dust mite sublingual immunotherapy. Methods This prospective real-life study was designed to include adults with moderate to severe allergic rhinitis sensitized to house dust mite who underwent a three-year course of sublingual immunotherapy. Control of symptoms was assessed by Rhinitis Control Assessment Test (RCAT) after three years of house dust mite sublingual immunotherapy. Additionally, patients assessed their symptoms by utilizing a visual analog scale. Results A total number of 86 consecutively enrolled patients (46 (53.49%) men; mean age 26.10 years (SD = 5.85)) with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust mite were evaluated. When assessed by RCAT on the third year, 74 (86.05%) had well-controlled symptoms and 20 (27.03%) of them were completely controlled. A significant reduction in visual analog scale scores—from 7.52 cm at baseline to 2.31 cm—was established ( P < 0.0001). There was a strong negative correlation between RCAT scores and visual analog scale (r = −0.65; P < 0.01). Conclusion This study provided evidence that a three-year course of house dust mite sublingual immunotherapy appears effective in controlling the symptoms of allergic rhinitis.

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