Role of platelet-derived growth factor-α in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps

2014 ◽  
Vol 4 (11) ◽  
pp. 909-914 ◽  
Author(s):  
Hai Lin ◽  
Dong Lin ◽  
Xi-Sheng Xiong ◽  
Xiong-Xiong Dai ◽  
Ting Lin
Keyword(s):  
Growth Factor ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Platelet Derived Growth Factor ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Factor Α

The Role of Transforming Growth Factor-α on Mucin Overproduction in Eosinophilic Chronic Rhinosinusitis

Pharmacology ◽  
2011 ◽  
Vol 88 (5-6) ◽  
pp. 302-308 ◽  
Author(s):  
Hajime Ishinaga ◽  
Said Ahmad Shah ◽  
Hiroshi Sakaida ◽  
Kazuhiko Takeuchi
Keyword(s):  
Growth Factor ◽  
Chronic Rhinosinusitis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Α ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Factor Α

Role of local allergic inflammation and Staphylococcus aureus enterotoxins in Chinese patients with chronic rhinosinusitis with nasal polyps

2017 ◽  
Vol 131 (8) ◽  
pp. 707-713 ◽  
Author(s):  
K-J Cheng ◽  
Y-Y Xu ◽  
M-L Zhou ◽  
S-H Zhou ◽  
S-Q Wang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Staphylococcal Enterotoxin ◽  
Eosinophilic Chronic Rhinosinusitis ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Local Allergy

AbstractObjective:To investigate the role of local allergic inflammation and Staphylococcus aureus enterotoxins in chronic rhinosinusitis with nasal polyps.Methods:This study included 36 patients with chronic rhinosinusitis with nasal polyps and 18 controls. Total immunoglobulin E, eosinophil cationic protein, staphylococcal enterotoxin types A and B specific immunoglobulin E, staphylococcal enterotoxin types A and B, and myeloperoxidase levels were determined.Results:Four patients with chronic rhinosinusitis with nasal polyps had a local allergy. All chronic rhinosinusitis with nasal polyps patients tested negative for staphylococcal enterotoxin types A and B specific immunoglobulin E. The chronic rhinosinusitis with nasal polyps group had significantly elevated staphylococcal enterotoxin types A and B levels in the supernatant. Fourteen patients belonged to the eosinophilic chronic rhinosinusitis with nasal polyps group and the others were characterised as having non-eosinophilic chronic rhinosinusitis with nasal polyps.Conclusion:Local allergy may play a role in chronic rhinosinusitis with nasal polyps, independent of staphylococcal enterotoxin superantigens. Staphylococcal enterotoxins may be important in the pathogenesis of chronic rhinosinusitis with nasal polyps; however, their roles as superantigens were not confirmed in this study. In Chinese subjects, chronic rhinosinusitis with nasal polyps usually manifests as a neutrophilic inflammation.

Evidence that platelet-derived growth factor may be a novel endogenous pyrogen in the central nervous system

2000 ◽  
Vol 278 (5) ◽  
pp. R1275-R1281 ◽  
Author(s):  
Irene R. Pelá ◽  
Márcia E. S. Ferreira ◽  
Miriam C. C. Melo ◽  
Carlos A. A. Silva ◽  
Márcio M. Coelho ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factor ◽  
Third Ventricle ◽  
Platelet Derived Growth Factor ◽  
Febrile Response ◽  
The Central Nervous System ◽  
Factor Α ◽  
Colonic Temperature

Platelet-derived growth factor (PDGF) exerts neurotrophic and neuromodulatory actions in the mammalian central nervous system (CNS). Like the cytokines, PDGF primarily signals through tyrosine phosphorylation-dependent pathways that activate multiple intracellular molecules including Janus family kinases. We previously showed that microinjection of PDGF-BB into the lateral ventricle induced a febrile response in rats that was reduced by pretreatment with Win 41662, a potent inhibitor of PDGF receptors (Pelá IR, Ferreira MES, Melo MCC, Silva CAA, and Valenzuela CF. Ann NY Acad Sci 856: 289–293, 1998). In this study, we further characterized the role of PDGF-BB in the febrile response in rats. Microinjection of PDGF-BB into the third ventricle produced a dose-dependent increase in colonic temperature that peaked 3–4 h postinjection. Win 41662 attenuated fever induced by intraperitoneal injection of bacterial lipopolysaccharide, suggesting that endogenous PDGF participates in the febrile response to this exogenous pyrogen. Importantly, febrile responses induced by tumor necrosis factor-α, interleukin-1β, and interleukin-6 were unchanged by Win 41662. Both indomethacin and dexamethasone blocked the PDGF-BB-induced increase in colonic temperature, and, therefore, we postulate that PDGF-BB may act via prostaglandin- and/or inducible enzyme-dependent pathways. Thus our findings suggest that PDGF-BB is an endogenous CNS mediator of the febrile response in rats.

Role of NLRP3 Inflammasome in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Inflammation ◽  
2016 ◽  
Vol 39 (6) ◽  
pp. 2045-2052 ◽  
Author(s):  
Hai Lin ◽  
Zhipeng Li ◽  
Dong Lin ◽  
Chunquan Zheng ◽  
Weitian Zhang
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nlrp3 Inflammasome ◽  
Nasal Polyps ◽  
Eosinophilic Chronic Rhinosinusitis

scholarly journals The Role of Hepatocyte Growth Factor/c-Met in Chronic Rhinosinusitis with Nasal Polyps

2010 ◽  
Vol 24 (4) ◽  
pp. 266-270 ◽  
Author(s):  
Douglas D. Reh ◽  
Murugappan Ramanathan ◽  
Babar Sultan ◽  
Yadong Wang ◽  
Lindsey May ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Factor C ◽  
Hepatocyte Growth

scholarly journals Role of P2X7R in eosinophilic and non‑eosinophilic chronic rhinosinusitis with nasal polyps

2021 ◽  
Vol 24 (1) ◽  
Author(s):  
Yan Wang ◽  
Shan Chen ◽  
Wenwen Wang ◽  
Jianjun Chen ◽  
Weijia Kong ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Eosinophilic Chronic Rhinosinusitis

The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps

2018 ◽  
Vol 138 (9) ◽  
pp. 830-836 ◽  
Author(s):  
Naoki Sugimoto ◽  
Tsuguhisa Nakayama ◽  
Yoshiyuki Kasai ◽  
Daiya Asaka ◽  
Ryoto Mitsuyoshi ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Eosinophilic Chronic Rhinosinusitis
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