scholarly journals Using teeth as tools: Investigating the mother–infant dyad and developmental origins of health and disease hypothesis using vitamin D deficiency

2019 ◽  
Vol 171 (2) ◽  
pp. 342-353 ◽  
Author(s):  
Megan B. Brickley ◽  
Bonnie Kahlon ◽  
Lori D'Ortenzio
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Developmental Origins ◽  
Health And Disease ◽  
Teeth As Tools

scholarly journals Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

2019 ◽  
Vol 241 (2) ◽  
pp. R65-R80 ◽  
Author(s):  
Folami Y Ideraabdullah ◽  
Anthony M Belenchia ◽  
Cheryl S Rosenfeld ◽  
Seth W Kullman ◽  
Megan Knuth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Later Life ◽  
The Body ◽  
Fetal Life ◽  
Developmental Origins ◽  
Long Term Effects ◽  
Cardiometabolic Disorders ◽  
Health And Disease

Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.

scholarly journals Vitamin D in health and disease: an insight into traditional functions and new roles for the ‘sunshine vitamin’

2009 ◽  
Vol 22 (2) ◽  
pp. 118-136 ◽  
Author(s):  
David Borradale ◽  
Michael Kimlin
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Health ◽  
Food Sources ◽  
Dietary Vitamin ◽  
International Studies ◽  
Uvb Radiation ◽  
Vitamin D Receptors ◽  
Ability To Act ◽  
Health And Disease

Vitamin D is unique among the vitamins in that man can synthesise it via the action of UV radiation upon the skin. This combined with its ability to act on specific target tissues via vitamin D receptors (VDR) make its classification as a steroid hormone more appropriate. While vitamin D deficiency is a recognised problem in some northern latitude countries, recent studies have shown that even in sunny countries, such as Australia, vitamin D deficiency may be more prevalent than first thought. Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health. These include possible associations with autoimmune diseases such as multiple sclerosis and inflammatory bowel diseases, cancer, CVD and muscle strength. First, this paper presents an overview of the two sources of vitamin D: exposure to UVB radiation and food sources of vitamin D, with particular focus on both Australian and international studies on dietary vitamin D intake and national fortification strategies. Second, the paper reviews recent epidemiological and experimental evidence linking vitamin D and its role in health and disease for the major conditions linked to suboptimal vitamin D, while identifying significant gaps in the research and possible future directions for research.

Vitamin D Deficiency

2011 ◽  
Vol 44 (14) ◽  
pp. 22
Author(s):  
WILLIAM E. GOLDEN ◽  
ROBERT H. HOPKINS
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency

Abstract #1236: The Blood Turnover Markers and Parathormon Levels in Menopausal Women with Vitamin D Deficiency

2015 ◽  
Vol 21 ◽  
pp. 293-294
Author(s):  
Mara Carsote ◽  
Cristina Capatina ◽  
Alexandra Mihai ◽  
Andreea Geleriu ◽  
Rodica Petris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Menopausal Women ◽  
Turnover Markers
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