Ancestry dynamics in a South American population: The impact of gene flow and preferential mating

2017 ◽  
Vol 163 (3) ◽  
pp. 474-479 ◽  
Author(s):  
Philip W. Hedrick
Author(s):  
Josimar E. Chire Saire

BACKGROUND Infoveillance is an application from Infodemiology field with the aim to monitor public health and create public policies. Social sensor is the people providing thought, ideas through electronic communication channels(i.e. Internet). The actual scenario is related to tackle the covid19 impact over the world, many countries have the infrastructure, scientists to help the growth and countries took actions to decrease the impact. South American countries have a different context about Economy, Health and Research, so Infoveillance can be a useful tool to monitor and improve the decisions and be more strategical. The motivation of this work is analyze the capital of Spanish Speakers Countries in South America using a Text Mining Approach with Twitter as data source. The preliminary results helps to understand what happens two weeks ago and opens the analysis from different perspectives i.e. Economics, Social. OBJECTIVE Analyze the behaviour of South American Capitals in front of covid19 pandemics and show the helpfulness of Text Mining Approach for Infoveillance tasks. METHODS Text Mining process RESULTS - Argentina and Venezuela capitals are the biggest number of post during this period, opposite with Bolivia, Ecuador and Uruguay. - Most relevant users are related to mass media like radio, television or newspapers. - There is a general concern about covid19 but every country talks about different areas: Economics, Health, Environmental Impact. CONCLUSIONS Infoveillance based on Social Sensors with data coming from Twitter can help to understand the trends on the population of the capitals. Besides, it is necessary to filter the posts for processing the text and get insights about frequency, top users, most important terms. This data is useful to analyse the population from different approaches. INTERNATIONAL REGISTERED REPORT RR2-https://doi.org/10.1101/2020.04.06.20055749


2018 ◽  
Vol 101 ◽  
pp. 294-302 ◽  
Author(s):  
Anaque de Oliveira Pires ◽  
Gerson de Almeida Queiroz ◽  
Milca de Jesus Silva ◽  
Raimon Rios da Silva ◽  
Hugo Bernardino Ferreira da Silva ◽  
...  

2010 ◽  
Vol 4 (3) ◽  
pp. 187-193 ◽  
Author(s):  
A. Blanco-Verea ◽  
J.C. Jaime ◽  
M. Brión ◽  
A. Carracedo

2007 ◽  
Vol 178 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Lilian Jara ◽  
Monica L. Acevedo ◽  
Rafael Blanco ◽  
Victor G. Castro ◽  
Teresa Bravo ◽  
...  

2014 ◽  
Vol 41 (6) ◽  
pp. 3715-3722 ◽  
Author(s):  
Isabel Elematore ◽  
Patricio Gonzalez-Hormazabal ◽  
Jose M. Reyes ◽  
Rafael Blanco ◽  
Teresa Bravo ◽  
...  

Genes ◽  
2018 ◽  
Vol 9 (9) ◽  
pp. 427 ◽  
Author(s):  
Sebastián Morales ◽  
Tomas De Mayo ◽  
Felipe Gulppi ◽  
Patricio Gonzalez-Hormazabal ◽  
Valentina Carrasco ◽  
...  

Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect.


BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Patricio González-Hormazábal ◽  
Teresa Bravo ◽  
Rafael Blanco ◽  
Carlos Y Valenzuela ◽  
Fernando Gómez ◽  
...  

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