scholarly journals The aging of Wolff's ?law?: Ontogeny and responses to mechanical loading in cortical bone

2004 ◽  
Vol 125 (S39) ◽  
pp. 63-99 ◽  
Author(s):  
Osbjorn M. Pearson ◽  
Daniel E. Lieberman
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Wolff’S Law

MIDKINE DEFICIENCY INCREASES THE ANABOLIC RESPONSE OF CORTICAL BONE TO MECHANICAL LOADING

2012 ◽  
Vol 45 ◽  
pp. S91
Author(s):  
Astrid Liedert ◽  
Laura Mattausch ◽  
Daniel Vogele ◽  
Marcus Pahl ◽  
Ronny Bindl ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Anabolic Response

Erratum to “Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice” [Bone 43 (2008) 238–248]

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1192-1195
Author(s):  
Toshihiro Sugiyama ◽  
Leanne K. Saxon ◽  
Gul Zaman ◽  
Alaa Moustafa ◽  
Andrew Sunters ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cortical Bone ◽  
Mechanical Loading

MECHANICAL LOADING INDUCES BONE FORMATION AND INCREASED VASCULARIZATION IN CORTICAL BONE

2008 ◽  
Vol 41 ◽  
pp. S50
Author(s):  
Gisela Kuhn ◽  
Philipp Schneider ◽  
Duncan Webster ◽  
Elad Wasserman ◽  
Ralph Müller
Keyword(s):  
Bone Formation ◽  
Cortical Bone ◽  
Mechanical Loading

Cortical bone adapts to controlled mechanical loading in vivo by architectural modification

Bone ◽  
1996 ◽  
Vol 18 (1) ◽  
pp. S103-S104
Author(s):  
JR Mosley ◽  
J Lynch ◽  
LE Lanyon
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading

Transcriptional profiling of cortical bone after mechanical loading in the MOPC315.BM myeloma bone disease model

2019 ◽  
Vol 19 (10) ◽  
pp. e37-e38
Author(s):  
Fani Ziouti ◽  
Maximilian Rummler ◽  
Catherine Julien ◽  
Regina Ebert ◽  
Franz Jakob ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Mechanical Loading ◽  
Bone Disease ◽  
Transcriptional Profiling ◽  
Disease Model ◽  
Myeloma Bone Disease

scholarly journals Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice

2016 ◽  
Vol 311 (1) ◽  
pp. E138-E144 ◽  
Author(s):  
Johan Svensson ◽  
Sara H. Windahl ◽  
Leanne Saxon ◽  
Klara Sjögren ◽  
Antti Koskela ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Cortical Bone ◽  
Mechanical Loading ◽  
Cortical Porosity ◽  
Bone Area ◽  
Osteogenic Response ◽  
Igf I ◽  
Cortical Bone Mass ◽  
And Control ◽  
Bone Mechanical Strength

Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone anabolic effect of mechanical loading. Here, we determined the role of endocrine IGF-I for the osteogenic response to mechanical loading in young adult and old female mice with adult, liver-specific IGF-I inactivation (LI-IGF-I−/− mice, serum IGF-I reduced by ≈70%) and control mice. The right tibia was subjected to short periods of axial cyclic compressive loading three times/wk for 2 wk, and measurements were performed using microcomputed tomography and mechanical testing by three-point bending. In the nonloaded left tibia, the LI-IGF-I−/− mice had lower cortical bone area and increased cortical porosity, resulting in reduced bone mechanical strength compared with the controls. Mechanical loading induced a similar response in LI-IGF-I−/− and control mice in terms of cortical bone area and trabecular bone volume fraction. In fact, mechanical loading produced a more marked increase in cortical bone mechanical strength, which was associated with a less marked increase in cortical porosity, in the LI-IGF-I−/− mice compared with the control mice. In conclusion, liver-derived IGF-I regulates cortical bone mass, cortical porosity, and mechanical strength under normal (nonloaded) conditions. However, despite an ∼70% reduction in circulating IGF-I, the osteogenic response to mechanical loading was not attenuated in the LI-IGF-I−/− mice.

scholarly journals NaQuinate selectively synergises with in vivo mechanical loading stimuli to enhance cortical bone mass and architectural modifications

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100885
Author(s):  
Behzad Javaheri ◽  
Amy Lock ◽  
Mark Hopkinson ◽  
Samuel Monzem ◽  
Yu-Mei Chang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cortical Bone ◽  
Mechanical Loading ◽  
Cortical Bone Mass
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