Overview of age‐related changes in psychomotor and cognitive functions in a prosimian primate, the gray mouse lemur ( Microcebus murinus ): Recent advances in risk factors and antiaging interventions

2021 ◽  
Vol 83 (11) ◽  
Author(s):  
Yohann Chaudron ◽  
Fabien Pifferi ◽  
Fabienne Aujard
Keyword(s):  
Risk Factors ◽  
Cognitive Functions ◽  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Recent Advances ◽  
Age Related ◽  
Gray Mouse Lemur ◽  
Age Related Changes

scholarly journals Hearing and Age-Related Changes in the Gray Mouse Lemur

2014 ◽  
Vol 15 (6) ◽  
pp. 993-1005 ◽  
Author(s):  
Christian Schopf ◽  
Elke Zimmermann ◽  
Julia Tünsmeyer ◽  
Sabine B. R. Kästner ◽  
Peter Hubka ◽  
...  
Keyword(s):  
Mouse Lemur ◽  
Age Related ◽  
Gray Mouse Lemur ◽  
Age Related Changes

Abstract T P136: Potential Contributors to the Declining Impact of Stroke Risk Factors with Age: Implications for Stroke Epidemiology in the Elderly

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
George Howard ◽  
Mary Cushman ◽  
Maciej Banach ◽  
Brett M Kissela ◽  
David C Goff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Stroke Risk ◽  
Multivariable Analysis ◽  
The Elderly ◽  
Stroke Risk Factors ◽  
Age Related ◽  
Increased Risk ◽  
The Impact ◽  
Age Related Changes

Purpose: The importance of stroke research in the elderly is increasing as America is “graying.” For most risk factors for most diseases (including stroke), the magnitude of association with incident events decreases at older ages. Potential changes in the impact of risk factors could be a “true” effect, or could be due to methodological issues such as age-related changes in residual confounding. Methods: REGARDS followed 27,748 stroke-free participants age 45 and over for an average of 5.3 years, during which 715 incident strokes occurred. The association of the “Framingham” risk factors (hypertension [HTN], diabetes, smoking, AFib, LVH and heart disease) with incident stroke risk was assessed in age strata of 45-64 (Young), 65-74 (Middle), and 75+ (Old). For those with and without an “index” risk factor (e.g., HTN), the average number of “other” risk factors was calculated. Results: With the exception of AFib, there was a monotonic decrease in the magnitude of the impact across the age strata, with HTN, diabetes, smoking and LVH even becoming non-significant in the elderly (Figure 1). However, for most factors, the increasing prevalence of other risk factors with age impacts primarily those with the index risk factor absent (Figure 2, example HTN as the “index” risk factor). Discussion: The impact of stroke risk factors substantially declined at older ages. However, this decrease is partially attributable to increases in the prevalence of other risk factors among those without the index risk factor, as there was little change in the prevalence of other risk factors in those with the index risk factor. Hence, the impact of the index risk factor is attenuated by increased risk in the comparison group. If this phenomenon is active with latent risk factors, estimates from multivariable analysis will also decrease with age. A deeper understanding of age-related changes in the impact of risk factors is needed.

scholarly journals Modulation of Gene Expression in Key Survival Pathways During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus

2015 ◽  
Vol 13 (2) ◽  
pp. 111-118 ◽  
Author(s):  
Kyle K. Biggar ◽  
Cheng-Wei Wu ◽  
Shannon N. Tessier ◽  
Jing Zhang ◽  
Fabien Pifferi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Daily Torpor ◽  
Survival Pathways ◽  
Modulation Of Gene Expression ◽  
Gray Mouse Lemur

Brown fat and nonshivering thermogenesis in the gray mouse lemur (Microcebus murinus)

2003 ◽  
Vol 284 (3) ◽  
pp. R811-R818 ◽  
Author(s):  
F. Génin ◽  
M. Nibbelink ◽  
M. Galand ◽  
M. Perret ◽  
L. Ambid
Keyword(s):  
Metabolic Rate ◽  
Cold Exposure ◽  
Uncoupling Protein ◽  
Brown Fat ◽  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Tropical Species ◽  
Daily Torpor ◽  
Nonshivering Thermogenesis ◽  
Gray Mouse Lemur

The gray mouse lemur Microcebus murinus is a rare example of a primate exhibiting daily torpor. In captive animals, we examined the metabolic rate during arousal from torpor and showed that this process involved nonshivering thermogenesis (NST). Under thermoneutrality (28°C), warming-up from daily torpor (body temperature <33°C) involved a rapid (<5 min) increase of O2 consumption that was proportional to the depth of torpor ( n = 8). The injection of a β-adrenergic agonist (isoproterenol) known to elicit NST induced a dose-dependent increase in metabolic rate ( n = 8). Moreover, maximum thermogenesis was increased by cold exposure. For the first time in this species, anatomic and histological examination using an antibody against uncoupling protein (UCP) specifically demonstrated the presence of brown fat. With the use of Western blotting with the same antibody, we showed a likely increase in UCP expression after cold exposure, suggesting that NST is also used to survive low ambient temperatures in this tropical species.

scholarly journals Primate Torpor: Regulation of Stress-activated Protein Kinases During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus

2015 ◽  
Vol 13 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Kyle K. Biggar ◽  
Cheng-Wei Wu ◽  
Shannon N. Tessier ◽  
Jing Zhang ◽  
Fabien Pifferi ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Daily Torpor ◽  
Gray Mouse Lemur
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