Travel medicine meets conservation medicine in st. kitts: Disinhibition, cognitive‐affective inconsistency, and disease risk among vacationers around green monkeys ( Chlorocebus sabaeus )

2021 ◽  
Author(s):  
Michael P. Muehlenbein ◽  
Kerry M. Dore ◽  
Jeffrey Gassen ◽  
Vy Nguyen ◽  
O. Grace Jolley ◽  
...  
Keyword(s):  
Disease Risk ◽  
Travel Medicine ◽  
Conservation Medicine ◽  
Green Monkeys

scholarly journals microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO

2019 ◽  
Vol 51 (2) ◽  
pp. 59-71 ◽  
Author(s):  
Alisha R. Coffey ◽  
Matt Kanke ◽  
Tangi L. Smallwood ◽  
Jody Albright ◽  
Wendy Pitman ◽  
...  
Keyword(s):  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Atherosclerotic Lesion ◽  
Atherogenic Diet ◽  
Chromosome 12 ◽  
Small Rna Sequencing ◽  
Chow Diet ◽  
Sequencing Analysis ◽  
Mouse Population ◽  
Green Monkeys

Trimethylamine-N-oxide (TMAO), a microbial choline metabolism byproduct that is processed in the liver and excreted into circulation, is associated with increased atherosclerotic lesion formation and cardiovascular disease risk. Genetic regulators of TMAO levels are largely unknown. In the present study, we used 288 mice from a genetically heterogeneous mouse population [Diversity Outbred (DO)] to determine hepatic microRNA associations with TMAO in the context of an atherogenic diet. We also validated findings in two additional animal models of atherosclerosis: liver-specific insulin receptor knockout mice fed a chow diet (LIRKO) and African green monkeys fed high-fat/high-cholesterol diet. Small RNA-sequencing analysis in DO mice, LIRKO mice, and African green monkeys identified only one hepatic microRNA (miR-146a-5p) that is aberrantly expressed across all three models. Moreover, miR-146a-5p levels are associated with circulating TMAO after atherogenic diet in each of these models. We also performed high-resolution genetic mapping and identified a novel quantitative trait locus on Chromosome 12 for TMAO levels. This interval includes two genes, Numb and Dlst, which are inversely correlated with both miR-146a and TMAO and are predicted targets of miR-146a. Both of these genes have been validated as direct targets of miR-146a, though in other cellular contexts. This is the first report to our knowledge of a link between miR-146 and TMAO. Our findings suggest that miR-146-5p, as well as one or more genes at the Chromosome 12 QTL (possibly Numb or Dlst), is strongly linked to TMAO levels and likely involved in the control of atherosclerosis.

Immune Electron Microscopy (IEM) of a Canine Adeno-Associated Virus

1974 ◽  
Vol 32 ◽  
pp. 256-257
Author(s):  
Gunter F. Thomas ◽  
M. David Hoggan
Keyword(s):  
Electron Microscopy ◽  
Cell Cultures ◽  
Complement Fixation ◽  
Hepatitis Virus ◽  
Wide Distribution ◽  
Immune Electron Microscopy ◽  
Adeno Associated Virus ◽  
Virus Like Particle ◽  
Dog Kidney ◽  
Green Monkeys

In 1968, Sugimura and Yanagawa described a small 25 nm virus like particle in association with the Matsuda strain of infectious canine hepatitis virus (ICHV). Domoto and Yanagawa showed that this particle was dependent on ICHV for its replication in primary dog kidney cell cultures (PDK) and was resistant to heating at 70°C for 10 min, and concluded that it was a canine adeno-associated virus (CAAV). Later studies by Onuma and Yanagawa compared CAAV with the known human serotypes (AAV 1, 2, 3) and AAV-4, known to be associated with African Green Monkeys. Using the complement fixation (CF) test, they found that CAAV was serologically related to AAV-3 and had wide distribution in the dog population of Japan.

Irregular Menses Linked To Coronary Disease Risk

Ob Gyn News ◽  
2007 ◽  
Vol 42 (24) ◽  
pp. 1-7
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Coronary Disease ◽  
Disease Risk ◽  
Irregular Menses
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