Comparative neuropathology in aging primates: A perspective

2021 ◽  
Author(s):  
Carmen Freire‐Cobo ◽  
Melissa K. Edler ◽  
Merina Varghese ◽  
Emily Munger ◽  
Jessie Laffey ◽  
...  
Keyword(s):  
Comparative Neuropathology

Comparative Neuropathology

BMJ ◽  
1963 ◽  
Vol 1 (5347) ◽  
pp. 1730-1730
Author(s):  
C. E. Lumsden
Keyword(s):  
Comparative Neuropathology

COMPARATIVE NEUROPATHOLOGY

1964 ◽  
Vol 40 (9) ◽  
pp. 338-338
Author(s):  
C. H. Gallagher
Keyword(s):  
Comparative Neuropathology

scholarly journals Comparative Neuropathology of Kuru with the New Variant of Creutzfeldt-Jakob Disease: Evidence for Strain of Agent Predominating Over Genotype of Host

2006 ◽  
Vol 8 (3) ◽  
pp. 429-437 ◽  
Author(s):  
CA McLean ◽  
JW Ironside ◽  
MP Alpers ◽  
PW Brown ◽  
L Cervenakova ◽  
...  
Keyword(s):  
Comparative Neuropathology ◽  
New Variant ◽  
Jakob Disease

scholarly journals COMPARATIVE STUDIES BETWEEN PATHOGENESIS OF STREET AND FIXED RABIES INFECTION

1967 ◽  
Vol 125 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Kaneatsu Miyamoto ◽  
Seiichi Matsumoto
Keyword(s):  
Electron Microscopy ◽  
Virus Infection ◽  
Light And Electron Microscopy ◽  
Selective Vulnerability ◽  
Ground Substance ◽  
Characteristic Matrix ◽  
Comparative Neuropathology ◽  
Full Development ◽  
The Matrix ◽  
Striking Contrast

Comparative neuropathology of Ammon's horn caused by both the street and fixed rabies infection was studied by combined light and electron microscopy. Neurons containing Negri bodies appeared comparatively little damaged. In striking contrast, in the case of fixed virus infection, neurons showed the following variety of degeneration. Lightly damaged neurons showed an increase in the number of small vesicles throughout the cytoplasm. A considerable number of lysosomes were also encountered within these nerve cells. Severe necrotic alteration involving the nucleus as well as the cytoplasm was found in the nerve cell band. The characteristic homogeneous foci (matrices) were discernible within these neurons. It appears that the matrix is morphologically identical with the ground substance of the Negri body, though its size is smaller than that of the Negri body. This evidence suggests a possibility that fixed virus injures neurons so extensively that they cannot bring about the full development of the characteristic matrix of the Negri body recognizable by the light microscope. Selective vulnerability was demonstrated among different groups of neurons in respect of cytopathogenesis of both street and fixed virus infection.

Sign in / Sign up

Export Citation Format

Share Document