Neuroendocrine regulation of prolactin secretion in adult female rhesus monkeys during different phases of the menstrual cycle: role of neuroexcitatory amino acid (NMA)

2007 ◽  
Vol 69 (4) ◽  
pp. 395-406 ◽  
Author(s):  
S. Jahan ◽  
S. Jalali ◽  
S.A. Shami
Keyword(s):  
Amino Acid ◽  
Menstrual Cycle ◽  
Adult Female ◽  
Rhesus Monkeys ◽  
Prolactin Secretion ◽  
Neuroendocrine Regulation ◽  
Female Rhesus

Reproductive endocrine effects of intranasal administration of progesterone to adult female rhesus monkeys

1985 ◽  
Vol 110 (4) ◽  
pp. 461-468 ◽  
Author(s):  
G. F. X. David ◽  
V. Puri ◽  
A. K. Dubey ◽  
C. P. Puri ◽  
T. C. Anand Kumar
Keyword(s):  
Menstrual Cycle ◽  
Phase Ii ◽  
Adult Female ◽  
Rhesus Monkeys ◽  
Intranasal Administration ◽  
Type I ◽  
Luteal Function ◽  
Menstrual Cycles ◽  
Female Rhesus ◽  
Endocrine Profile

Abstract. Adult female rhesus monkeys exhibiting normal ovulatory menstrual cycles were treated with progesterone nasal sprays. Animals in group A (n = 9) were treated with the solvent only (controls). Animals in groups B (n = 6), C (n = 17) and D (n = 7), respectively, were treated with a daily dose of 0.4, 2 and 10 μg of progesterone and the spraying was done between days 5–14 of the cycle. Ovulation was monitored by laparoscopy on day 20. The serum endocrine profile throughout the treated menstrual cycle was studied with respect to oestradiol and progesterone. Bioactive luteinizing hormone (bLH) was studied in blood samples taken on the day of the mid-cycle oestradiol peak, 2 days before, and 2 days after. The menstrual cycle was divided into two phases with respect to the mid-cycle oestradiol peak: phase I was taken to include day 1 of the cycle to the day of the oestradiol peak, and the remaining part of the menstrual cycle was considered to be phase II. The serum-endocrine profile in the controls was similar to that observed in normal ovulatory menstrual cycles. However, in the progesterone-treated groups three types of menstrual cycles were discernable on the basis of the serum endocrine profile. In the type I menstrual cycle, observed only in group C (n = 10), the mid-cycle bLH peak was abolished and the progesterone levels remained low throughout the cycle. Laparoscopy revealed these to be anovulatory cycles. In the type II menstrual cycle, seen in the 3 animals of group B, 2 animals of group C, and in all the 7 animals of group D, the mid-cycle bLH peak was abolished and the progesterone levels during phase II of the cycle were significantly lower than in the controls, indicative of poor luteal function. In the type III menstrual cycle seen in the remaining monkeys, the serum endocrine profile did not differ from that seen in the controls. Thus, the present studies indicate that the intranasal administration of progesterone shows a dose-response effect with respect to the suppression of the oestradiol induced mid-cycle surge of bLH. Suppression of the mid-cycle bLH peak resulted in anovulatory cycles or ovulatory cycles with poor luteal function.

Physical activity of adult female rhesus monkeys (Macaca mulatta) across the menstrual cycle

2007 ◽  
Vol 292 (6) ◽  
pp. E1520-E1525 ◽  
Author(s):  
Nathan A. Hunnell ◽  
Nathan J. Rockcastle ◽  
Kristen N. McCormick ◽  
Laurel K. Sinko ◽  
Elinor L. Sullivan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Menstrual Cycle ◽  
Adult Female ◽  
Rhesus Monkeys ◽  
Reproductive Hormones ◽  
Follicular Phase ◽  
The Body ◽  
Activity Levels ◽  
Female Rhesus ◽  
Early Follicular Phase

Physical activity is an important physiological variable impacting on a number of systems in the body. In rodents and several species of domestic animals, levels of physical activity have been reported to vary across the estrous cycle; however, it is unclear whether such changes in activity occur in women and other primates across the menstrual cycle. To determine whether significant changes in activity occur over the menstrual cycle, we continuously measured physical activity in seven adult female rhesus monkeys by accelerometry over the course of one menstrual cycle. Monkeys were checked daily for menses, and daily blood samples were collected for measurement of reproductive hormones. All monkeys displayed ovulatory menstrual cycles, ranging from 23 to 31 days in length. There was a significant increase in estradiol from the early follicular phase to the day of ovulation (F1.005,5.023 = 40.060, P = 0.001). However, there was no significant change in physical activity across the menstrual cycle (F2,12 = 0.225, P = 0.802), with activity levels being similar in the early follicular phase, on the day of the preovulatory rise in estradiol and during the midluteal phase. Moreover, the physical activity of these monkeys was not outside the range of physical activity that we measured in 15 ovariectomized monkeys. We conclude that, in primates, physical activity does not change across the menstrual cycle and is not influenced by physiological changes in circulating estradiol. This finding will allow investigators to record physical activity in female primates without the concern of controlling for the phase of the menstrual cycle.

scholarly journals An increase in in vivo release of LHRH and precocious puberty by posterior hypothalamic lesions in female rhesus monkeys (Macaca mulatta)

2007 ◽  
Vol 292 (4) ◽  
pp. E1000-E1009 ◽  
Author(s):  
Bret M. Windsor-Engnell ◽  
Etsuko Kasuya ◽  
Masaharu Mizuno ◽  
Kim L. Keen ◽  
Ei Terasawa
Keyword(s):  
Precocious Puberty ◽  
Rhesus Monkeys ◽  
Gaba Release ◽  
Good Tool ◽  
Subsequent Increase ◽  
Female Rhesus ◽  
Before And After ◽  
Lhrh Release

We have previously shown that a decrease in γ-aminobutyric acid (GABA) tone and a subsequent increase in glutamatergic tone occur in association with the pubertal increase in luteinizing hormone releasing hormone (LHRH) release in primates. To further determine the causal relationship between developmental changes in GABA and glutamate levels and the pubertal increase in LHRH release, we examined monkeys with precocious puberty induced by lesions in the posterior hypothalamus (PH). Six prepubertal female rhesus monkeys (17.4 ± 0.1 mo of age) received lesions in the PH, three prepubertal females (17.5 ± 0.1 mo) received sham lesions, and two females received no treatments. LHRH, GABA, and glutamate levels in the stalk-median eminence before and after lesions were assessed over two 6-h periods (0600–1200 and 1800–2400) using push-pull perfusion. Monkeys with PH lesions exhibited external signs of precocious puberty, including significantly earlier menarche in PH lesion animals (18.8 ± 0.2 mo) than in sham/controls (25.5 ± 0.9 mo, P < 0.001). Moreover, PH lesion animals had elevated LHRH levels and higher evening glutamate levels after lesions, whereas LHRH changes did not occur in sham/controls until later. Changes in GABA release were not discernible, since evening GABA levels already deceased at 18–20 mo of age in both groups and morning levels remained at the prepubertal levels. The age of first ovulation in both groups did not differ. Collectively, PH lesions may not be a good tool to investigate the mechanism of puberty, and, taking into account the recent findings on the role of kisspeptins, the mechanism of the puberty onset in primates is more complex than we initially anticipated.

Western-style diet (WSD) with and without testosterone (T) exposure changes follicular structure-function in young adult, female rhesus monkeys

2013 ◽  
Vol 100 (3) ◽  
pp. S338
Author(s):  
C.V. Bishop ◽  
W.K. McGee ◽  
E. Galbreath ◽  
M.B. Zelinski ◽  
J.L. Cameron ◽  
...  
Keyword(s):  
Young Adult ◽  
Structure Function ◽  
Adult Female ◽  
Rhesus Monkeys ◽  
Female Rhesus

Fibrous Plaques in the Aortas of Adult Female Rhesus Monkeys (Macaco mulatta)

1975 ◽  
Vol 4 (2) ◽  
pp. 120-128 ◽  
Author(s):  
Beverly Y. Cockrell ◽  
M.G. Valerio ◽  
W.F. Loeb
Keyword(s):  
Adult Female ◽  
Rhesus Monkeys ◽  
Female Rhesus
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