Amidation Reaction of Quinoline‐3‐carboxylic Acids with Tetraalkylthiuram Disulfides under Simple Conditions: A facile Synthesis of Quinoline‐3‐carboxamides

2020 ◽  
Vol 9 (12) ◽  
pp. 2191-2195
Author(s):  
Jingyan Hu ◽  
Xiefeng Ye ◽  
Shuai Hao ◽  
Qianrui Zhao ◽  
Mingqin Zhao ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Facile Synthesis ◽  
Amidation Reaction

scholarly journals Site-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yunyun Ning ◽  
Shuaishuai Wang ◽  
Muzi Li ◽  
Jie Han ◽  
Chengjian Zhu ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Functional Group ◽  
Amide Bond ◽  
Coupling Reagents ◽  
Complex Molecules ◽  
Bond Forming ◽  
Synergistic Catalysis ◽  
Wide Range ◽  
Amidation Reaction ◽  
Forming Methods

AbstractDevelopment of catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. In this paper, we disclose an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI2, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participate smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield). This Umpolung amidation strategy opens a method to address challenging regioselectivity issues between nucleophilic functional groups, and complements the functional group compatibility of the classical amidation protocols. The synthetic robustness of the reaction is demonstrated by late-stage modification of complex molecules and gram-scale applications.

scholarly journals Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

2017 ◽  
Vol 15 (30) ◽  
pp. 6426-6432 ◽  
Author(s):  
Daan F. J. Hamstra ◽  
Danny C. Lenstra ◽  
Tjeu J. Koenders ◽  
Floris P. J. T. Rutjes ◽  
Jasmin Mecinović
Keyword(s):  
Carboxylic Acids ◽  
Phosphine Oxide ◽  
Bond Formation ◽  
Reducing Agent ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Amidation Reaction

In situ reduction of phosphine oxide by poly(methylhydrosiloxane) leads to efficient amidation reaction between carboxylic acids and amines.

ChemInform Abstract: Facile Synthesis of α-Hydroxy Carboxylic Acids from the Corresponding α-Amino Acids.

ChemInform ◽  
2014 ◽  
Vol 45 (51) ◽  
pp. no-no
Author(s):  
Nicolai Stuhr-Hansen ◽  
Shahrokh Padrah ◽  
Kristian Stroemgaard
Keyword(s):  
Amino Acids ◽  
Carboxylic Acids ◽  
Facile Synthesis ◽  
Hydroxy Carboxylic Acids

Samarium(III) triflate: a new catalyst for facile synthesis of benzothiazoles and benzoxazoles from carboxylic acids in aqueous media

2014 ◽  
Vol 41 (11) ◽  
pp. 8355-8362 ◽  
Author(s):  
Pratapsinha B. Gorepatil ◽  
Yogesh D. Mane ◽  
Amarsinha B. Gorepatil ◽  
Mahadev V. Gaikwad ◽  
Vilas S. Ingle
Keyword(s):  
Carboxylic Acids ◽  
Aqueous Media ◽  
Facile Synthesis

Mechanism of arylboronic acid-catalyzed amidation reaction between carboxylic acids and amines

2013 ◽  
Vol 11 (13) ◽  
pp. 2140 ◽  
Author(s):  
Chen Wang ◽  
Hai-Zhu Yu ◽  
Yao Fu ◽  
Qing-Xiang Guo
Keyword(s):  
Carboxylic Acids ◽  
Arylboronic Acid ◽  
Amidation Reaction ◽  
Acid Catalyzed
Sign in / Sign up

Export Citation Format

Share Document