Transition‐Metal‐Free C‐S Bond Forming Strategy towards Synthesis of Highly Diverse Pyrazole Tethered Benzothiazoles: Investigation of their Photophysical Properties

2020 ◽  
Vol 9 (11) ◽  
pp. 1857-1868
Author(s):  
Shubham Sharma ◽  
Chandi C. Malakar ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Photophysical Properties ◽  
Metal Free ◽  
Bond Forming ◽  
Forming Strategy

scholarly journals Transition-metal-free allylation of 2-azaallyls with allyl ethers through polar and radical mechanisms

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Guogang Deng ◽  
Shengzu Duan ◽  
Jing Wang ◽  
Zhuo Chen ◽  
Tongqi Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Allyl Ether ◽  
Metal Catalyst ◽  
Metal Free ◽  
Allyl Ethers ◽  
Bond Forming ◽  
Allyl Halides ◽  
Synthetic Utility ◽  
Insight Into ◽  
Allyl Esters

AbstractAllylation of nucleophiles with highly reactive electrophiles like allyl halides can be conducted without metal catalysts. Less reactive electrophiles, such as allyl esters and carbonates, usually require a transition metal catalyst to facilitate the allylation. Herein, we report a unique transition-metal-free allylation strategy with allyl ether electrophiles. Reaction of a host of allyl ethers with 2-azaallyl anions delivers valuable homoallylic amine derivatives (up to 92%), which are significant in the pharmaceutical industry. Interestingly, no deprotonative isomerization or cyclization of the products were observed. The potential synthetic utility and ease of operation is demonstrated by a gram scale telescoped preparation of a homoallylic amine. In addition, mechanistic studies provide insight into these C(sp3)–C(sp3) bond-forming reactions.

Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction

2007 ◽  
Vol 4 (4) ◽  
pp. 292-295 ◽  
Author(s):  
Sarbani Pal ◽  
P. Bindu ◽  
Pragnyadhar Reddy Venna ◽  
P. K. Dubey
Keyword(s):  
Transition Metal ◽  
Lewis Acid ◽  
Metal Free ◽  
Bond Forming

scholarly journals Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

2020 ◽  
Vol 16 ◽  
pp. 1740-1753 ◽  
Author(s):  
Dharmender Singh ◽  
Vipin Kumar ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Elemental Sulfur ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
One Pot ◽  
Light Emitting ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Synthetic Strategy ◽  
Reaction Proceeds

A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO. This expeditious catalyst-free reaction proceeds through the formation of β-carboline-based 2-nitrochalcones followed by an incorporation of sulfur to generate multifunctional β-carboline-linked benzothiophenones in good to excellent yields. The synthetic strategy could also be extended towards the synthesis of β-carboline-linked benzothiophenes. Moreover, the afforded products emerged as promising fluorophores and displayed excellent light-emitting properties with quantum yields (ΦF) up to 47%.

Nucleophilicity parameters for designing transition metal-free C–C bond forming reactions of organoboron compounds

2012 ◽  
Vol 3 (3) ◽  
pp. 878-882 ◽  
Author(s):  
Guillaume Berionni ◽  
Biplab Maji ◽  
Paul Knochel ◽  
Herbert Mayr
Keyword(s):  
Transition Metal ◽  
Organoboron Compounds ◽  
Metal Free ◽  
Bond Forming ◽  
Bond Forming Reactions

Novel Naproxen Derivatives: Lewis Acid/Transition-Metal Free Synthesis via C—C Bond Forming Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (51) ◽  
Author(s):  
Sarbani Pal ◽  
P. Bindu ◽  
Pragnyadhar Reddy Venna ◽  
P. K. Dubey
Keyword(s):  
Transition Metal ◽  
Lewis Acid ◽  
Metal Free ◽  
Bond Forming
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