5‐HT2AR and BDNF gene variants in eating disorders susceptibility

2019 ◽  
Vol 183 (3) ◽  
pp. 155-163 ◽  
Author(s):  
M. Rachele Ceccarini ◽  
Anna Tasegian ◽  
Marica Franzago ◽  
F. Filomena Patria ◽  
Elisabetta Albi ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Gene Variants ◽  
Bdnf Gene

scholarly journals An Evolutionary Genetic Perspective of Eating Disorders

2017 ◽  
Vol 106 (3) ◽  
pp. 292-306 ◽  
Author(s):  
Alexandra J. Mayhew ◽  
Marie Pigeyre ◽  
Jennifer Couturier ◽  
David Meyre
Keyword(s):  
Risk Factors ◽  
Eating Disorders ◽  
Family Environment ◽  
Genetic Risk ◽  
Cultural Influences ◽  
Gene Variants ◽  
Biological Mechanisms ◽  
Binary Variable ◽  
Evolutionary Genetic ◽  
New Perspective

Eating disorders (ED) including anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) affect up to 5% of the population in Western countries. Risk factors for developing an ED include personality traits, family environment, gender, age, ethnicity, and culture. Despite being moderately to highly heritable with estimates ranging from 28 to 83%, no genetic risk factors have been conclusively identified. Our objective was to explore evolutionary theories of EDs to provide a new perspective on research into novel biological mechanisms and genetic causes of EDs. We developed a framework that explains the possible interactions between genetic risk and cultural influences in the development of ED. The framework includes three genetic predisposition categories (people with mainly AN restrictive gene variants, people with mainly BED variants, and people with gene variants predisposing to both diseases) and a binary variable of either the presence or absence of pressure to be thin. We propose novel theories to explain the overlapping characteristics of the subtypes of AN (binge/purge and restrictive), BN, and BED. For instance, mutations/structural gene variants in the same gene causing opposite effects or mutations in nearby genes resulting in partial disequilibrium for the genes causing AN (restrictive) and BED may explain the overlap of phenotypes seen in AN (binge/purge).

The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain

2012 ◽  
Vol 39 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Gwyneth C.M. Zai ◽  
Clement C.H. Zai ◽  
Nabilah I. Chowdhury ◽  
Arun K. Tiwari ◽  
Renan P. Souza ◽  
...  
Keyword(s):  
Weight Gain ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Gene Variants ◽  
Bdnf Gene

Investigation of Brain-Derived Neurotrophic Factor (BDNF) Gene Variants in Migraine

2014 ◽  
Vol 54 (7) ◽  
pp. 1184-1193 ◽  
Author(s):  
Heidi G. Sutherland ◽  
Bridget H. Maher ◽  
Astrid J. Rodriguez-Acevedo ◽  
Larisa M. Haupt ◽  
Lyn R. Griffiths
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Gene Variants ◽  
Bdnf Gene

No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease

2006 ◽  
Vol 24 (2) ◽  
pp. 274-279 ◽  
Author(s):  
Emilio Di Maria ◽  
Antonella Marasco ◽  
Marzia Tartari ◽  
Paola Ciotti ◽  
Giovanni Abbruzzese ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Age At Onset ◽  
Gene Variants ◽  
Bdnf Gene

Association study between BDNF gene variants and Mexican patients with obsessive–compulsive disorder

2013 ◽  
Vol 23 (11) ◽  
pp. 1600-1605 ◽  
Author(s):  
Lidia Márquez ◽  
Beatriz Camarena ◽  
Sandra Hernández ◽  
Cristina Lóyzaga ◽  
Luis Vargas ◽  
...  
Keyword(s):  
Association Study ◽  
Obsessive Compulsive Disorder ◽  
Gene Variants ◽  
Bdnf Gene ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Mexican Patients

P111: BDNF Gene Variants in Subjects with Chronic Tinnitus

2006 ◽  
Vol 135 (2_suppl) ◽  
pp. P249-P250 ◽  
Author(s):  
Tobias Kleinjung ◽  
Birgit Fischer ◽  
Berthold Langguth ◽  
Peter Eichhammer ◽  
Goeran Hajak ◽  
...  
Keyword(s):  
Chronic Tinnitus ◽  
Gene Variants ◽  
Bdnf Gene

scholarly journals Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population

2019 ◽  
Vol 9 (7) ◽  
Author(s):  
Alma Delia Genis‐Mendoza ◽  
David Ruiz‐Ramos ◽  
María Lilia López‐Narvaez ◽  
Carlos Alfonso Tovilla‐Zárate ◽  
Ana Rosa García ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Genetic Association ◽  
Association Analysis ◽  
Mexican Population ◽  
Gene Variants ◽  
Genetic Association Analysis ◽  
Htr2a Gene
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