scholarly journals Genetic and environmental contributions to the association between ADHD and affective problems in early childhood-A Swedish population-based twin study

2017 ◽  
Vol 174 (5) ◽  
pp. 538-546 ◽  
Author(s):  
Mina Rydell ◽  
Mark J. Taylor ◽  
Henrik Larsson
Keyword(s):  
Early Childhood ◽  
Twin Study ◽  
Population Based ◽  
Swedish Population

scholarly journals A Swedish Population-Based Multivariate Twin Study of Externalizing Disorders

2015 ◽  
Vol 46 (2) ◽  
pp. 183-192 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Sara Larsson Lönn ◽  
Hermine H. Maes ◽  
Paul Lichtenstein ◽  
Jan Sundquist ◽  
...  
Keyword(s):  
Twin Study ◽  
Externalizing Disorders ◽  
Population Based ◽  
Swedish Population

Sibling Alcohol Use Disorder Is Associated With Increased Risk for Suicide Attempt

2021 ◽  
pp. 216770262110250
Author(s):  
Mallory E. Stephenson ◽  
Sara Larsson Lönn ◽  
Jessica E. Salvatore ◽  
Jan Sundquist ◽  
Kenneth S. Kendler ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Suicide Attempt ◽  
Alcohol Use Disorder ◽  
Cox Regression ◽  
Population Based ◽  
Swedish Population ◽  
Sibling Pairs ◽  
Increased Risk ◽  
Using Data ◽  
Shared Genetic

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based registers with national coverage. Among full sibling pairs (656,807 males and 607,096 females), we found that, even after we accounted for the proband’s AUD status, the proband’s risk for suicide attempt was significantly elevated when the proband’s sibling was affected by AUD. Furthermore, the proband’s risk for suicide attempt was consistently higher when the sibling’s AUD registration had occurred more recently. Our findings provide evidence for exposure to sibling AUD as an environmental risk factor for suicide attempt and suggest that clinical outreach may be warranted following a sibling’s diagnosis with AUD.

scholarly journals Early Childhood Experiences and Kindergarten Success: A Population-Based Study of a Large Urban Setting

2005 ◽  
Vol 34 (4) ◽  
pp. 571-588 ◽  
Author(s):  
John W. Fantuzzo ◽  
Heather L. Rouse ◽  
Paul A. McDermott ◽  
Yumiko Sekino ◽  
Stephanie Childs ◽  
...  
Keyword(s):  
Early Childhood ◽  
Population Based ◽  
Urban Setting ◽  
Population Based Study ◽  
Childhood Experiences

scholarly journals POS0392 PRESENCE OF FOUR SERUM AUTOANTIBODIES ASSOCIATES WITH THE ACPA STATUS IN EARLY RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 425.3-426
Author(s):  
L. Lourido ◽  
C. Ruiz-Romero ◽  
L. Collado ◽  
M. Hansson ◽  
L. Klareskog ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Early Diagnosis ◽  
Specific Antigen ◽  
Coiled Coil ◽  
Population Based ◽  
Mitogen Activated Protein Kinase ◽  
Absolute Deviation ◽  
Swedish Population ◽  
Early Ra ◽  
Acpa Status

Background:The presence of anti-citrullinated protein antibodies (ACPAs) is a hallmark of rheumatoid arthritis (RA) that precede the development of the disease by years and is used for its clinical diagnosis. However, there are RA subjects that test negative for ACPA and thus the early diagnosis on these patients may be delayed. Furthermore, the presence or absence of ACPA in RA supports the hypothesis that on these two subsets of patients underlie different pathogenesis and clinical outcomes.Objectives:In this work, we searched for serum autoantibodies useful to assist the early diagnosis of ACPA-seronegative RA and its management.Methods:We profiled the serum autoantibody repertoire of 80 ACPA-seronegative and 80 ACPA-seropositive RA subjects from the Swedish population-based Epidemiological Investigation of RA (EIRA) cohort. A suspension bead array platform built on protein fragments within Human Protein Atlas and selected from an initial untargeted screening using arrays containing 2660 total antigens was employed to identify IgG and IgA serum autoantibodies. A validation phase on antigen suspension bead arrays was carried out on another set of samples from EIRA containing 386 ACPA-seropositive, 358 ACPA-seronegative and 372 randomly selected control subjects of the same age and sex. A sample-specific threshold based on 20 times the median absolute deviation plus the median of all signals was selected to determine the reactivity of samples. The Wilcoxon rank sum test and Fisher’s test were applied for the comparison of autoantibody levels and reactivity frequencies between the groups.Results:Our data revealed four antigens associated with the ACPA status (Table 1). Testis-specific Y-encoded-like protein 4 (TSPYL4) showed significantly higher IgG reactivity frequency in ACPA-seronegative subjects compared to ACPA-seropositive (8% vs. 3%; P<0.05). Significant differences at IgG autoantibody levels (P<0.05) were also observed between ACPA-seronegative subjects and controls for this specific antigen. Significantly higher IgG autoantibody levels (P<0.05) towards another antigen, dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6), were also observed in ACPA-seronegative subjects compared to ACPA-seropositive and controls. In contrast, we found significantly higher IgG autoantibody levels (P<0.05) in ACPA-seropositive individuals compared to ACPA-seronegative and controls towards two antigens, anosmin-1 (ANOS-1) and muscle related coiled-coil protein (MURC). ANOS-1 shows also significantly higher IgG reactivity frequency in ACPA-seropositive individuals compared to ACPA-seronegative and controls (22%, 9% and 6% respectively; P<0.05). Interestingly, three out of the four antigens discovered to be associated with the ACPA status in early RA are highly expressed in lungs and heart, two of the main extraarticular sites affected in RA. No significant differences were observed at IgA levels for any of the antigens analyzed.Table 1.Scheme of the different phases of the study, the features within each phase and the results. The reactivity to four antigens allows to distinguish ACPA-seronegative (ACPA-), ACPA seropositive (ACPA+) and controls.PhasesUntargeteddiscoveryTargeteddiscoveryTargetedvalidationNumber of samples80 ACPA-80 ACPA-358 ACPA-372 Controls80 ACPA+80 ACPA+386 ACPA+Antigen arrayplatformPlanararraysSuspensionbead array 1Suspensionbead array 2Number of antigens26606227Number of candidatebiomarkers6227 4 (TSPYL4,MAP2K6,ANOS1,MURC)Conclusion:Upon further validation in other early RA sample cohorts, our data suggest the measurement of these four autoantibodies may be useful for the early diagnosis of ACPA-seronegative RA and give insight into the pathogenesis of the different RA subsets.Characters from table content including title and footnotes:Disclosure of Interests:None declared

Perceived Threat of Violence and Exposure to Physical Violence Against Foreign-Born Women: A Swedish Population-Based Study

2011 ◽  
Vol 21 (3) ◽  
pp. 206-213 ◽  
Author(s):  
Cecilia Fernbrant ◽  
Birgitta Essén ◽  
Per-Olof Östergren ◽  
Elizabeth Cantor-Graae
Keyword(s):  
Physical Violence ◽  
Population Based ◽  
Perceived Threat ◽  
Foreign Born ◽  
Swedish Population ◽  
Population Based Study

Adolescent religiousness and its influence on substance use: preliminary findings from the Mid-Atlantic School Age Twin Study

Twin Research ◽  
1999 ◽  
Vol 2 (2) ◽  
pp. 156-168 ◽  
Author(s):  
Brian M D'Onofrio ◽  
Lenn Murrelle ◽  
Lindon J Eaves ◽  
Michael E McCullough ◽  
Jessica L Landis ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Problem Behavior ◽  
Twin Study ◽  
Structural Equation ◽  
Population Based ◽  
Spiritual Practices ◽  
Equation Modeling ◽  
School Age ◽  
Attitudes And Practices

AbstractResearch has consistently shown that religiousness is associated with lower levels of alcohol and drug use, but little is known about the nature of adolescent religiousness or the mechanisms through which it influences problem behavior in this age group. This paper presents preliminary results from the Mid-Atlantic School Age Twin Study, a prospective, population-based study of 6–18-year-old twins and their mothers. Factor analysis of a scale developed to characterize adolescent religiousness, the Religious Attitudes and Practices Inventory (RAPI), revealed three factors: theism, religious/spiritual practices, and peer religiousness. Twin correlations and univariate behavior-genetic models for these factors and a measure of belief that drug use is sinful reveal in 357 twin pairs that common environmental factors significantly influence these traits, but a minor influence of genetic factors could not be discounted. Correlations between the multiple factors of adolescent religiousness and substance use, comorbid problem behavior, mood disorders, and selected risk factors for substance involvement are also presented. Structural equation modeling illustrates that specific religious beliefs about the sinfulness of drugs and level of peer religiousness mediate the relationship between theistic beliefs and religious/spiritual practices on substance use. Limitations and future analyses are discussed.

Non-Contraceptive Hormones and Rheumatoid Arthritis: Possibilities of Using a Swedish Population-Based Cohort

Rheumatology ◽  
1989 ◽  
Vol XXVIII (suppl 1) ◽  
pp. 38-40
Author(s):  
P. Allebeck ◽  
H-O. Adami ◽  
L. Klareskog ◽  
I. Persson
Keyword(s):  
Rheumatoid Arthritis ◽  
Population Based ◽  
Swedish Population
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