scholarly journals Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder

2015 ◽  
Vol 168 (6) ◽  
pp. 480-491 ◽  
Author(s):  
Cristina Sánchez-Mora ◽  
Vanesa Richarte ◽  
Iris Garcia-Martínez ◽  
Mireia Pagerols ◽  
Montse Corrales ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Dopamine Receptor ◽  
Life Events ◽  
Attention Deficit ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Drd4 Gene ◽  
Hyperactivity Disorder

scholarly journals Risky Sexual Behavior and Its Association With Attention-Deficit Hyperactivity Disorder, Stressful Life Events, and Other Psychiatric Correlates Among Women in Sex Work

2021 ◽  
pp. 263183182110285
Author(s):  
Kasthuri Pandiyan ◽  
Shankar Kumar ◽  
Sushmitha Kota
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Sexual Behavior ◽  
Life Events ◽  
Sex Work ◽  
Attention Deficit ◽  
Risky Sexual Behavior ◽  
Adult Adhd ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Hyperactivity Disorder

Introduction: Numerous psychiatric disorders are known to be associated with risky sexual behavior (RSB). Depression or substance use is known to be higher in those who are in sex work. Recent literature has also described the association between attention-deficit hyperactivity disorder (ADHD) and RSB. However, the association between ADHD and RSB among women in sex work (WSW) is relatively unknown. In this background, this study was conducted to study the prevalence of ADHD and associated psychiatric correlates among WSW and also to study the prevalence of RSB in this population. Methodology: A sample of 96 women who were in sex work and consented to be the part of the study were recruited. They were later administered Adult ADHD Self-Report Scale to screen for adult ADHD symptoms, Wender Utah Rating Scale to retrospectively look into a childhood diagnosis of ADHD, MINI neuropsychiatric interview for DSM 4-TR psychiatric diagnoses, HIV Risk Behavior Scale to study RSB, Beck’s Depression Inventory to quantify depression, and Presumptive Stressful Life Events Scale to quantify the presence of stressful life events. Results: The prevalence of Adult ADHD in the sample was 32.20 % (n = 31). Individuals with ADHD had a higher prevalence of RSB ( P = .02), comorbid depression ( P = .04), presence of stressful life events ( P = .001), and a higher prevalence of sexually transmitted infections ( P = .03). Conclusion: The prevalence of ADHD is high among WSW (32%). Risky sexual behavior in this population could be probably due to higher prevalence of associated psychiatric conditions including depression, higher presence of stressful life events, and ADHD, the association which is less understood. There is a need to replicate these findings in larger samples to study ADHD and its relationship with risky sexual behavior among WSW.

scholarly journals DRD4 Gene Polymorphisms as a Risk Factor for Children with Attention Deficit Hyperactivity Disorder in Iranian Population

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Seyed Mahmoud Tabatabaei ◽  
Shahrokh Amiri ◽  
Sara Faghfouri ◽  
Seyed Gholamreza Noorazar ◽  
Shahin AbdollahiFakhim ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Tandem Repeats ◽  
Receptor Gene ◽  
Variable Number ◽  
Healthy Children ◽  
Drd4 Gene ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Northwest Of Iran

Background and Objective. Dopamine dysfunction is known to be associated with attention deficit hyperactivity disorder (ADHD). Dopamine D4 receptor gene (DRD4) is one of the important genes in this pathway. This study intended to investigate the variable number of tandem repeats (VNTR) in exon 3 of the DRD4 gene in Iranian children and adolescents. Materials and Methods. In this study, 130 children with ADHD, aged 6–14 years, and 130 healthy children, within the same age range, were enrolled. All children were selected from northwest of Iran which have Caucasian ethnic background and are of a Turkic ethnic group. VNTR polymorphisms of the DRD4 gene were evaluated by PCR using exon 3-specific primers followed by agarose gel electrophoresis. Findings. The Hardy-Weinberg principle and Chi-square test showed a significant difference in 4-repetition (4R) alleles between the ADHD (76.2%) and control (53.8%) groups (p=0.004; X2=17.39; df=5). The least percentage of repetition alleles in both groups was 2R. Conclusion. There is a significant correlation between the 4R alleles of DRD4 and ADHD in the northwest of Iran.

scholarly journals Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder

2003 ◽  
Vol 9 (5) ◽  
pp. 500-509 ◽  
Author(s):  
V L Misener ◽  
P Luca ◽  
O Azeke ◽  
J Crosbie ◽  
I Waldman ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Dopamine Receptor ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals Determining the association between polymorphisms of the DAT1 and DRD4 genes with attention deficit hyperactivity disorder in children from Java Island

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Cempaka Thursina ◽  
Dian Kesumapramudya Nurputra ◽  
Indra Sari Kusuma Harahap ◽  
Nur Imma Fatimah Harahap ◽  
Nihayatus Sa’adah ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Genotype Distribution ◽  
Drd4 Gene ◽  
Normal Children ◽  
Repeat Allele ◽  
Hyperactivity Disorder ◽  
Vntr Polymorphism ◽  
Dat1 Gene ◽  
Significant Difference

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioural in the children. Genetic factor is known one of the factors which contributed in ADHD development. VNTR polymorphism in 3’UTR exon 15 of DAT1 gene and exon 3 of DRD4 gene are reported to be associated in ADHD. In this study we examine the association of ADHD with VNTR polymorphism of DAT1 and DRD4 gene in Indonesian children. Sixty-five ADHD children and 70 normal children (6- 13 years of age), were included in the study, we matched by age and gender. ADHD was diagnosed by DSM-IV. We performed a casecontrol study to found the association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes. The 10-repeat allele of DAT1 and 2-repeat allele of DRD4 were higher in Indonesian children. Although the frequency of these allele was higher, but it was similar both in ADHD and control groups. Neither DAT1 nor DRD4 gene showed showed significant difference in genotype distribution and frequency allele between both groups (p > 0.05). No association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes found in Indonesian children. This data suggest that DAT1 and DRD4 do not contribute to etiology of ADHD in Indonesian children. Further studies are needed to clarify association between VNTR polymorphism of DAT1 and DRD4 genetic with ADHD of Indonesian children in larger sample size and family based study.

Sign in / Sign up

Export Citation Format

Share Document