Methylenetetrahydrofolate reductase (MTHFR) genetic variation and major depressive disorder prognosis: A five-year prospective cohort study of primary care attendees

2013 ◽  
Vol 165 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Chad A. Bousman ◽  
Maria Potiriadis ◽  
Ian P. Everall ◽  
Jane M. Gunn
Keyword(s):  
Primary Care ◽  
Major Depressive Disorder ◽  
Genetic Variation ◽  
Cohort Study ◽  
Depressive Disorder ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Methylenetetrahydrofolate Reductase ◽  
Major Depressive

scholarly journals Screening for depression in high-risk groups: prospective cohort study in general practice

2009 ◽  
Vol 194 (5) ◽  
pp. 399-403 ◽  
Author(s):  
Kim D. Baas ◽  
Karin A. Wittkampf ◽  
Henk C. van Weert ◽  
Peter Lucassen ◽  
Jochanan Huyser ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Cohort Study ◽  
High Risk ◽  
Depressive Disorder ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Mental Health Problems ◽  
Risk Groups ◽  
Major Depressive ◽  
The People

BackgroundCurrently only about half of the people who have major depressive disorder are detected during regular health care. Screening in high-risk groups might be a possible solution.AimsTo evaluate the effectiveness of selective screening for major depressive disorder in three high-risk groups in primary care: people with mental health problems, people with unexplained somatic complaints and people who frequently attend their general practitioner.MethodProspective cohort study among 2005 people in high-risk groups in three health centres in The Netherlands.ResultsOf the 2005 people identified, 1687 were invited for screening and of these 780 participated. Screening disclosed 71 people with major depressive disorder: 36 (50.7%) already received treatment, 14 (19.7%) refused treatment and 4 individuals did not show up for an appointment. As a final result of the screening, 17 individuals (1% of 1687) started treatment for major depressive disorder.ConclusionsScreening for depression in high-risk populations does not seem to be effective, mainly because of the low rates of treatment initiation, even if treatment is freely and easily accessible.

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