Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations

2012 ◽  
Vol 159B (7) ◽  
pp. 786-793 ◽  
Author(s):  
Andreas Reif ◽  
Heike Weber ◽  
Katharina Domschke ◽  
Benedikt Klauke ◽  
Christian Baumann ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Meta Analysis ◽  
Specific Role ◽  
Female Specific ◽  
European Populations

scholarly journals A Female‐specific Role of RGS20 in Transcriptional, Epigenomic and Behavioral Responses to Chronic Pain

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Anne Ruiz ◽  
Sevasti Gaspari ◽  
Lorna Farrelly ◽  
Claire Polizu ◽  
kerri pryce ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Behavioral Responses ◽  
Specific Role ◽  
Female Specific

scholarly journals Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients

2020 ◽  
Vol 10 (4) ◽  
pp. 184
Author(s):  
Zhi-Lei Yu ◽  
Chung-Shun Wong ◽  
Yi Ting Lai ◽  
Wan-Hsuan Chou ◽  
Imaniar Noor Faridah ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Urinary Albumin ◽  
Urinary Protein ◽  
Creatinine Ratio ◽  
Genetic Associations ◽  
Male Population ◽  
Patients With Diabetes ◽  
European Populations

Renal dysfunction is common in patients with diabetes mellitus (DM). Previous findings from a meta-analysis of GWAS indicated that the variation of RAB38/CTSC is highly associated with the urinary albumin-to-creatinine ratio (UACR) in European populations. In addition, RAB38 knockout rats showed an increase in urinary albumins. Although the prevalence of chronic kidney disease is high in Taiwan, the role of genetic variants in diabetic renal function is still unclear. In the current study, 275 diabetic nephropathy (DN) patients were recruited to perform a genetic association study. Our results indicated that rs1027027, rs302647, and rs302646 in RAB38 were significantly associated with urinary protein-to-creatinine ratio (UPCR) levels in DN patients. Importantly, after analysis stratified by gender, a significant genetic influence on UPCR levels was observed in the male population. The findings confirmed the roles of gender and variants of RAB38 in the risk of UPCR in Diabetic Nephropathy patients.

Chronic Pain: Fundamental Scientific Considerations, Specifically for Legal Claims

2013 ◽  
Vol 18 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Robert J. Barth
Keyword(s):  
Health Outcomes ◽  
Pain Perception ◽  
Driving Forces ◽  
Psychological Treatment ◽  
Dominant Role ◽  
Meta Analysis ◽  
General Medicine ◽  
Pain Syndrome ◽  
Problematic Relationship

Abstract Scientific findings have indicated that psychological and social factors are the driving forces behind most chronic benign pain presentations, especially in a claim context, and are relevant to at least three of the AMA Guides publications: AMA Guides to Evaluation of Disease and Injury Causation, AMA Guides to Work Ability and Return to Work, and AMA Guides to the Evaluation of Permanent Impairment. The author reviews and summarizes studies that have identified the dominant role of financial, psychological, and other non–general medicine factors in patients who report low back pain. For example, one meta-analysis found that compensation results in an increase in pain perception and a reduction in the ability to benefit from medical and psychological treatment. Other studies have found a correlation between the level of compensation and health outcomes (greater compensation is associated with worse outcomes), and legal systems that discourage compensation for pain produce better health outcomes. One study found that, among persons with carpal tunnel syndrome, claimants had worse outcomes than nonclaimants despite receiving more treatment; another examined the problematic relationship between complex regional pain syndrome (CRPS) and compensation and found that cases of CRPS are dominated by legal claims, a disparity that highlights the dominant role of compensation. Workers’ compensation claimants are almost never evaluated for personality disorders or mental illness. The article concludes with recommendations that evaluators can consider in individual cases.

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