Association of catechol-O-methyl transferase (COMT) gene −287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population

2011 ◽  
Vol 156 (4) ◽  
pp. 393-400 ◽  
Author(s):  
Shiguo Liu ◽  
Yanhui Liu ◽  
Haiping Wang ◽  
Ruiling Zhou ◽  
Jinbao Zong ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Comt Gene ◽  
Chinese Han Population ◽  
Obsessive Compulsive ◽  
Chinese Han ◽  
Methyl Transferase ◽  
Han Population ◽  
Compulsive Disorder

A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

2012 ◽  
Vol 24 (3) ◽  
pp. 172-175 ◽  
Author(s):  
Shiguo Liu ◽  
Yanhui Liu ◽  
Yingying Yin ◽  
Xinhua Zhang ◽  
Xu Ma
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Case Control ◽  
Chinese Han Population ◽  
Interleukin 12 ◽  
Obsessive Compulsive ◽  
Chinese Han ◽  
Han Population ◽  
Compulsive Disorder ◽  
Pcr Rflp ◽  
Control Association

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

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