Genetic analysis of Parkin in early onset Parkinson's disease (PD): Novel intron 9 g > a single nucleotide polymorphism and risk of Taiwanese PD

2009 ◽  
Vol 9999B ◽  
pp. n/a-n/a
Author(s):  
Yih-Ru Wu ◽  
Chun-Hsien Wu ◽  
Chih-Ying Chao ◽  
Chun-Chieh Kuan ◽  
Wan-Ling Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphism ◽  
Genetic Analysis ◽  
Early Onset ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Early Onset Parkinson’S Disease

Analysis of single nucleotide polymorphism rs415430 in the WNT3 gene in Parkinson’s disease in Russian population

2011 ◽  
Vol 26 (2) ◽  
pp. 47-49
Author(s):  
E. V. Filatova ◽  
M. I. Shadrina ◽  
E. Yu. Fedotova ◽  
P. A. Slominsky ◽  
S. N. Illarioshkin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphism ◽  
Russian Population ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals The Single Nucleotide Polymorphism rs1014290 of the SLC2A9 Gene Is Associated with Uric Acid Metabolism in Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Jiangfang Miao ◽  
Jing Liu ◽  
Li Xiao ◽  
Jiedi Zheng ◽  
Chunfeng Liu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphism ◽  
Uric Acid ◽  
Chinese Population ◽  
Acid Metabolism ◽  
Minor Allele ◽  
Control Group ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

Individuals with Parkinson’s disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9, are associated with lower uric acid levels. We investigated the association of rs1014290 with uric acid metabolism in a cohort of PD cases (220) and controls (110) in a Han Chinese population. Uric acid levels were determined and rs1014290 was assayed using a mutation-sensitive on/off switch technology. PD uric acid levels (291.65 ± 76.29 μmol/L) were significantly lower than the controls (325.73 ± 74.23 μmol/L, P<0.001, t-test). Individuals with rs1014290 TT and CT genotypes had higher uric acid levels, and those with the CC genotype had the lowest uric acid levels among both control and PD cases. The CC genotype and the C minor allele were statistically more frequent in the PD group compared to the control group. Those with the CC genotype had a statistically significant higher risk of PD than those with the TT or TC genotype (odds ratio [OR] = 2.249, 95% confidence interval [CI]: 1.129–4.480, and P=0.021). Thus, SLC2A9 rs1014290 is related to lower uric acid levels in PD patients and can be a risk factor for PD in the Han population.

scholarly journals Genetic Analysis of RAB39B in an Early-Onset Parkinson's Disease Cohort

2020 ◽  
Vol 11 ◽  
Author(s):  
Yujing Gao ◽  
Gabrielle R. Wilson ◽  
Nicholas Salce ◽  
Alexandra Romano ◽  
George D. Mellick ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Analysis ◽  
Early Onset ◽  
Early Onset Parkinson’S Disease

scholarly journals A genetic analysis of a Spanish population with early onset Parkinson’s disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238098
Author(s):  
Tejera-Parrado Cristina ◽  
Mir Pablo ◽  
Periñán María Teresa ◽  
Vela-Desojo Lydia ◽  
Abreu-Rodríguez Irene ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Analysis ◽  
Early Onset ◽  
Spanish Population ◽  
Early Onset Parkinson’S Disease
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