Is the5-HTTLPR polymorphism associated with bipolar disorder or with suicidal behavior of bipolar disorder patients?

2007 ◽  
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pp. 114-116 ◽  
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L. Malloy-Diniz ◽  
A.A. Ferreira ◽  
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Carme Barrot ◽  
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2006 ◽  
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Andrew A. Nierenberg ◽  
Roy H. Perlis ◽  
Polina Eidelman ◽  
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2012 ◽  
Vol 2 (5) ◽  
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Zoltan Rihmer

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Priscilla T. Chan ◽  
David A. Langer ◽  
Martha C. Tompson

2020 ◽  
Author(s):  
Leonardo Tondo ◽  
Gustavo H. Vázquez ◽  
Ross J. Baldessarini

2009 ◽  
Vol 31 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Fernando Silva Neves ◽  
Leandro Fernandes Malloy-Diniz ◽  
Izabela Guimarães Barbosa ◽  
Paulo Marcos Brasil ◽  
Humberto Corrêa

OBJECTIVE: The objective of this study was to test the hypothesis that the polarity of the first mood episode may be a marker for suicidal behavior, particularly the violent subtype. METHOD: One hundred and sixty-eight patients diagnosed with bipolar disorder (DSM-IV) were grouped according to type of first episode: depression or manic/hypomanic. Groups were compared for demographic and clinical variables. We performed logistic regression in order to test the association between first episode polarity and suicidal behavior. RESULTS: We found that depressed patients have a lifetime history of more suicide attempts. However, univariate analysis of number of suicide attempts showed that the best model fits the bipolar II subtype (mean square = 15.022; p = 0.010) and lifetime history of psychotic episodes (mean square = 17.359; p = 0.021). Subgrouping the suicide attempts by subtype (violent or non-violent) revealed that manic/hypomanic patients had a greater tendency toward attempting violent suicide (21.2 vs. 14.7%, X² = 7.028, p = 0.03). Multiple logistic regression analysis confirmed this result. CONCLUSION: Depressed patients had more suicide attempts over time, which could be explained by the higher prevalence of bipolar II subtype in this group, whereas manic/hypomanic patients had a lifelong history of more frequent violent suicide attempts, not explained by any of the variables studied. Our results support the evidence that non-violent suicide attempters and violent suicide attempters tend to belong to different phenotypic groups.


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