Preliminary evidence for an association between a dopamine D3 receptor gene variant and obsessive-compulsive personality disorder in patients with major depression

2006 ◽  
Vol 141B (4) ◽  
pp. 409-413 ◽  
Author(s):  
Katrina J. Light ◽  
Peter R. Joyce ◽  
Suzanne E. Luty ◽  
Roger T. Mulder ◽  
Christropher M.A. Frampton ◽  
...  
Keyword(s):  
Major Depression ◽  
Personality Disorder ◽  
Receptor Gene ◽  
Preliminary Evidence ◽  
Dopamine D3 Receptor ◽  
Gene Variant ◽  
D3 Receptor ◽  
Obsessive Compulsive ◽  
Dopamine D3 ◽  
Obsessive Compulsive Personality Disorder

Lack of association between obsessive-compulsive disorder and the dopamine D3 receptor gene: Some preliminary considerations

1994 ◽  
Vol 54 (3) ◽  
pp. 253-255 ◽  
Author(s):  
Marco Catalano ◽  
Gabriella Sciuto ◽  
Daniela Di Bella ◽  
Emanuela Novelli ◽  
Maria Nobile ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dopamine D3

scholarly journals Dopamine D3 receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression

2013 ◽  
Vol 16 (7) ◽  
pp. 1443-1459 ◽  
Author(s):  
Udo Dannlowski ◽  
Katharina Domschke ◽  
Eva Birosova ◽  
Bruce Lawford ◽  
Ross Young ◽  
...  
Keyword(s):  
Major Depression ◽  
Electroconvulsive Therapy ◽  
Ventral Striatum ◽  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Total N ◽  
Gene Variation ◽  
Dopamine D3 ◽  
Drd3 Gene

Abstract Dysfunction of dopamine D3 receptors, particularly in the mesocorticolimbic system, has been linked to the pathogenesis of major depression. Preclinical data show enhanced D3 receptor binding in the striatum upon antidepressant medication and electroconvulsive therapy (ECT). Thus, the potential impact of dopamine D3 receptor gene (DRD3) variation on ECT outcome in treatment-resistant major depression was evaluated by applying a combined molecular and imaging genetic approach. Altogether, 10 representative variants covering 95.4% of DRD3 gene variation were investigated for association with response to ECT in a sample of 104 (71 female, 33 male) Caucasian patients with pharmacorefractory major depression. Additionally, ventral striatum responsiveness to happy faces was assessed in two independent samples of depressed patients (total N=54) by means of functional magnetic resonance imaging at 3 T. Significant association of DRD3 rs3732790, rs3773679 and rs9817063 variants with response (uncorrected p=0.02–0.03) and remission (uncorrected p=0.01) after ECT was discerned. Logistic regression analyses revealed association of rs3732790 (uncorrected p=0.009; corrected p=0.045) and rs3773679 (uncorrected p=0.009; corrected p=0.045) with remission when applying a recessive model of inheritance. The rs3732790T allele conferring a more favourable treatment response was furthermore found to be associated with stronger striatal responsiveness to happy facial expressions (sample 1: cluster-corrected p=0.002; sample 2: p=0.023). In summary, the present study suggests some impact of DRD3 gene variation on ECT response, potentially mediated by alteration of striatal engagement during the processing of emotionally rewarding stimuli.

scholarly journals Association of the Ser9Gly polymorphism in the dopamine D3 receptor gene with tardive dyskinesia in Korean schizophrenics

2002 ◽  
Vol 56 (4) ◽  
pp. 469-474 ◽  
Author(s):  
SUNG-IL WOO ◽  
JAE WON KIM ◽  
EUGENE RHA ◽  
SUN-HO HAN ◽  
KYU-HEE HAHN ◽  
...  
Keyword(s):  
Tardive Dyskinesia ◽  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3

Meta-analysis of the dopamine D3 receptor gene (DRD3) Ser9Gly variant and schizophrenia

2004 ◽  
Vol 14 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Erik G. J??nsson ◽  
Rolf Kaiser ◽  
J??rgen Brockm??ller ◽  
Vishwajit L. Nimgaonkar ◽  
Marc-Antoine Crocq
Keyword(s):  
Meta Analysis ◽  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3

Association between novelty seeking and the dopamine D3 receptor gene in bipolar patients

1997 ◽  
Vol 42 (1) ◽  
pp. 98S
Author(s):  
Luc Staner ◽  
Christiane Hilger ◽  
François Hentges ◽  
Jose Monreal ◽  
Annick Hoffmann ◽  
...  
Keyword(s):  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
Novelty Seeking ◽  
D3 Receptor ◽  
Dopamine D3 ◽  
Bipolar Patients

Eye movement disturbances and dopamine D3 receptor gene

2002 ◽  
Vol 17 ◽  
pp. 69
Author(s):  
J.K. Rybakowski ◽  
A. Borkowski ◽  
P. Czerski ◽  
J. Hauser
Keyword(s):  
Eye Movement ◽  
Receptor Gene ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3
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