Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder

2002 ◽  
Vol 116B (1) ◽  
pp. 55-59 ◽  
Author(s):  
Bruno Millet ◽  
Nadia Chabane ◽  
Richard Delorme ◽  
Marion Leboyer ◽  
Sophie Leroy ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Drd4 Gene ◽  
Compulsive Disorder ◽  
Dopamine Receptor D4

Association study between the dopamine receptor D4 gene and obsessive-compulsive disorder

2007 ◽  
Vol 17 (6-7) ◽  
pp. 406-409 ◽  
Author(s):  
Beatriz Camarena ◽  
Cristina Loyzaga ◽  
Alejandro Aguilar ◽  
Karen Weissbecker ◽  
Humberto Nicolini
Keyword(s):  
Association Study ◽  
Dopamine Receptor ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dopamine Receptor D4

No association between DRD4 gene and SRI treatment response in obsessive compulsive disorder: Need for a novel approach

2013 ◽  
Vol 6 (4) ◽  
pp. 347-348 ◽  
Author(s):  
Biju Viswanath ◽  
Reshma Jabeen Taj M.J. ◽  
Meera Purushottam ◽  
Thennarasu Kandavel ◽  
Pooja Harsha Shetty ◽  
...  
Keyword(s):  
Treatment Response ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Drd4 Gene ◽  
Compulsive Disorder ◽  
Novel Approach

DRD4 gene and obsessive compulsive disorder: Do symptom dimensions have specific genetic correlates?

2013 ◽  
Vol 41 ◽  
pp. 18-23 ◽  
Author(s):  
Reshma Jabeen Taj. M. J ◽  
Biju Viswanath ◽  
Meera Purushottam ◽  
Thennarasu Kandavel ◽  
Y.C. Janardhan Reddy ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Drd4 Gene ◽  
Symptom Dimensions ◽  
Compulsive Disorder

The 7-repeat variant of the DRD4 gene is increased in obsessive-compulsive disorder with tics

1997 ◽  
Vol 42 (1) ◽  
pp. 26S ◽  
Author(s):  
H. Nicolini ◽  
C. Cruz ◽  
B. Camarena ◽  
F. Páez ◽  
D. Sidenberg ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Drd4 Gene ◽  
Compulsive Disorder

scholarly journals Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder

2017 ◽  
Author(s):  
Graham K Murray ◽  
Franziska Knolle ◽  
Karen D Ersche ◽  
Kevin J Craig ◽  
Sanja Abbott ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Obsessive Compulsive Disorder ◽  
Prediction Error ◽  
Reward Processing ◽  
Anterior Cingulate ◽  
Obsessive Compulsive ◽  
Significant Group ◽  
Compulsive Disorder ◽  
Imaging Results ◽  
Significant Difference

AbstractRationalePatients with obsessive-compulsive disorder (OCD) have been found to show exaggerated error responses and prediction error learning signals in a variety of EEG and fMRI tasks, with data converging on the anterior cingulate cortex as a key locus of dysfunction. Considerable evidence has linked prediction error processing to dopaminergic function.ObjectiveIn this study we investigate potential dopaminergic dysfunction during reward processing in the context of OCD.MethodsWe studied OCD patients (n=18) and controls (n=18) whilst they learned probabilistic associations between abstract stimuli and monetary rewards in the fMRI scanner involving administration (on separate visits) of: a dopamine receptor agonist, pramipexole 0.5mg; a dopamine receptor antagonist, amisulpride 400mg, and placebo. We fitted a Q-learning computational model to fMRI prediction error responses; group differences were examined in anterior cingulate and nucleus accumbens regions of interest.ResultsThere were no significant group, drug or interaction effects in number of correct choices; computational modeling suggested a marginally significant difference in learning rates between groups (p=0.089, partial ⍰2=0.1). In the imaging results, there was a significant interaction of group by drug (p=0.013, partial ⍰2=0.13). OCD patients showed abnormally strong cingulate signaling of prediction errors during omission of an expected reward, with unexpected reduction by both pramipexole and amisulpride (p=0.014, partial ⍰2=0.26, 1-β error probability=0.94). Exaggerated cingulate prediction error signaling to omitted reward in placebo was related to trait subjective difficulty in self-regulating behavior in OCD.ConclusionsOur data support cingulate dysfunction during reward processing in OCD, and bidirectional remediation by dopaminergic modulation, suggesting that exaggerated cingulate error signals in OCD may be of dopaminergic origin. The results help to illuminate the mechanisms through which dopamine receptor antagonists achieve therapeutic benefit in OCD. Further research is needed to disentangle the different functions of dopamine receptor agonists and antagonists during bidirectional modulation of cingulate activation.

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