Myokine levels after resistance exercise in young adults with Prader–Willi syndrome (PWS)

2019 ◽  
Vol 182 (1) ◽  
pp. 115-121
Author(s):  
Harry J. Hirsch ◽  
Varda Gross‐Tsur ◽  
Yanir Sabag ◽  
Shachar Nice ◽  
Larry Genstil ◽  
...  
2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Harry Hirsch ◽  
Varda Gross-Tsur ◽  
Yanir Sabag ◽  
Yehuda Pollak ◽  
Shachar Nice ◽  
...  

2021 ◽  
Vol 53 (8S) ◽  
pp. 460-461
Author(s):  
Brett R. Gordon ◽  
Cillian P. McDowell ◽  
Mark Lyons ◽  
Matthew P. Herring

Amino Acids ◽  
2019 ◽  
Vol 51 (9) ◽  
pp. 1387-1395 ◽  
Author(s):  
José Maria Estoche ◽  
Jeferson Lucas Jacinto ◽  
Mirela Casonato Roveratti ◽  
Juliano Moro Gabardo ◽  
Cosme Franklim Buzzachera ◽  
...  

2019 ◽  
Vol 104 (9) ◽  
pp. 3931-3938
Author(s):  
Stephany H Donze ◽  
Al W de Weerd ◽  
Renilde A S van den Bossche ◽  
Koen F M Joosten ◽  
Anita C S Hokken-Koelega

Abstract Context Sleep-related breathing disorders (SRBD) are common in people with Prader-Willi syndrome (PWS). Young adults with PWS benefit from GH continuation after attaining adult height by maintaining the improved body composition obtained during childhood. There are, no studies about the effects of GH on SRBD in young adults with PWS who were treated with GH during childhood. Objective Investigate the effects of GH vs placebo on SRBD in young adults with PWS who were treated with GH during childhood and had attained adult height. Design Two-year, randomized, double-blind, placebo-controlled, crossover study in 27 young adults with PWS, stratified for sex and body mass index. Setting Dutch PWS Reference Center. Intervention Crossover intervention with GH (0.67 mg/m2/d) and placebo, both over one year. Main Outcome Measures Apnea hypopnea index (AHI), obstructive apnea index (OAI), central apnea index (CAI), measured by polysomnography. Results Compared with placebo, GH did not increase AHI, CAI, or OAI (P > 0.35). The effect of GH vs placebo was neither different between men and women, nor between patients with a deletion or maternal uniparental disomy/imprinting center defect. After two years, there was no difference in AHI, CAI, or OAI compared with baseline (P > 0.18). Two patients (7%) fulfilled the criteria of obstructive sleep apnea regardless of GH or placebo. Conclusions GH compared with placebo does not cause a substantial increase in AHI, CAI, or OAI in adults with PWS who were treated with GH during childhood and have attained adult height. Our findings are reassuring and prove that GH can be administered safely.


2018 ◽  
Vol 6 (14) ◽  
pp. e13799 ◽  
Author(s):  
Carl J. Hulston ◽  
Rachel M. Woods ◽  
Rebecca Dewhurst-Trigg ◽  
Sion A. Parry ◽  
Stephanie Gagnon ◽  
...  

2019 ◽  
Vol 91 (4) ◽  
pp. 578-579 ◽  
Author(s):  
Charlotte Höybye ◽  
Maithé Tauber ◽  
Moris A. Angulo ◽  
Urs Eiholzer ◽  
Daniel J. Driscoll ◽  
...  

2019 ◽  
Vol 45 ◽  
pp. S101
Author(s):  
Sayuki Kobayashi ◽  
Akiko Hayashi ◽  
Ayako Higashi ◽  
Syu Inami ◽  
Jun Tanaka ◽  
...  

2017 ◽  
Vol 87 (3) ◽  
pp. 153-161 ◽  
Author(s):  
Daniela A. Rubin ◽  
Susan J. Clark ◽  
Andrea M. Haqq ◽  
Diobel M. Castner ◽  
Jason Ng ◽  
...  

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