Neurochemical evaluation of brain function with1H magnetic resonance spectroscopy in patients with fragile X syndrome

2013 ◽  
Vol 164 (1) ◽  
pp. 99-105 ◽  
Author(s):  
G.E. Utine ◽  
B. Akpınar ◽  
U. Arslan ◽  
P.Ö.Ş. Kiper ◽  
B. Volkan-Salancı ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Fragile X Syndrome ◽  
Brain Function ◽  
Fragile X ◽  
Resonance Spectroscopy

Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy

Neurology ◽  
1996 ◽  
Vol 46 (4) ◽  
pp. 974-977 ◽  
Author(s):  
D.G. Gadian ◽  
E. B. Isaacs ◽  
J.H. Cross ◽  
A. Connelly ◽  
G. D. Jackson ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Function ◽  
Resonance Spectroscopy

scholarly journals Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

2009 ◽  
Vol 30 (1) ◽  
pp. 211-221 ◽  
Author(s):  
Fawzi Boumezbeur ◽  
Graeme F Mason ◽  
Robin A de Graaf ◽  
Kevin L Behar ◽  
Gary W Cline ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Function ◽  
Healthy Aging ◽  
Mitochondrial Metabolism ◽  
Elderly Subjects ◽  
Resonance Spectroscopy ◽  
Healthy Elderly ◽  
Age Related ◽  
Young Subjects

A decline in brain function is a characteristic feature of healthy aging; however, little is known about the biologic basis of this phenomenon. To determine whether there are alterations in brain mitochondrial metabolism associated with healthy aging, we combined 13C/1H magnetic resonance spectroscopy with infusions of [1-13C]glucose and [2-13C]acetate to quantitatively characterize rates of neuronal and astroglial tricarboxylic acid cycles, as well as neuroglial glutamate–glutamine cycling, in healthy elderly and young volunteers. Compared with young subjects, neuronal mitochondrial metabolism and glutamate–glutamine cycle flux was ∼30% lower in elderly subjects. The reduction in individual subjects correlated strongly with reductions in N-acetylaspartate and glutamate concentrations consistent with chronic reductions in brain mitochondrial function. In elderly subjects infused with [2-13C]acetate labeling of glutamine, C4 and C3 differed from that of the young subjects, indicating age-related changes in glial mitochondrial metabolism. Taken together, these studies show that healthy aging is associated with reduced neuronal mitochondrial metabolism and altered glial mitochondrial metabolism, which may in part be responsible for declines in brain function.

scholarly journals Magnetic resonance spectroscopy of the brain: a review of physical principles and technical methods

2015 ◽  
Vol 26 (6) ◽  
pp. 609-632 ◽  
Author(s):  
Michael H. Buonocore ◽  
Richard J. Maddock
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Brain Function ◽  
Pulse Sequences ◽  
Resonance Spectroscopy ◽  
Resonance Imaging ◽  
Neurobiological Substrates ◽  
Health And Disease ◽  
The Brain ◽  
Physical Principles

AbstractMagnetic resonance spectroscopy (MRS) provides unique information about the neurobiological substrates of brain function in health and disease. However, many of the physical principles underlying MRS are distinct from those underlying magnetic resonance imaging, and they may not be widely understood by neuroscientists new to this methodology. This review describes these physical principles and many of the technical methods in current use for MRS experiments. A better understanding these principles and methods may help investigators select pulse sequences and quantification methods best suited to the aims of their research program and avoid pitfalls that can hamper new investigators in this field.

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