Incidental findings in genetic research and clinical diagnostic tests: A systematic review

2012 ◽  
Vol 158A (12) ◽  
pp. 3159-3167 ◽  
Author(s):  
Leigh Jackson ◽  
Lesley Goldsmith ◽  
Anita O'Connor ◽  
Heather Skirton
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Incidental Findings ◽  
Genetic Research ◽  
Clinical Diagnostic

scholarly journals Incidental findings in imaging diagnostic tests: a systematic review

2010 ◽  
Vol 83 (988) ◽  
pp. 276-289 ◽  
Author(s):  
B Lumbreras ◽  
L Donat ◽  
I Hernández-Aguado
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Incidental Findings

scholarly journals Evidence-Based Review of Clinical Diagnostic Tests and Predictive Clinical Tests That Evaluate Response to Conservative Rehabilitation for Posterior Glenohumeral Instability: A Systematic Review

2018 ◽  
Vol 10 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Jasdeep Dhir ◽  
Myles Willis ◽  
Lyn Watson ◽  
Lyndsay Somerville ◽  
Jackie Sadi
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Glenohumeral Joint ◽  
Evidence Based ◽  
Clinical Tests ◽  
Posterior Instability ◽  
Glenohumeral Instability ◽  
Predictive Tests ◽  
Clinical Diagnostic ◽  
Weak Evidence

Context: Posterior glenohumeral instability is poorly understood and can be challenging to recognize and evaluate. Using evidence-based clinical and predictive tests can assist clinicians in appropriate assessment and management. Objective: To review evidence-based clinical diagnostic tests for posterior glenohumeral instability and predictive tests that identify responders to conservative management. Data Sources: A comprehensive electronic bibliographic search was conducted using Embase, Ovid MEDLINE, PEDro, and CINAHL databases from their date of inception to February 2017. Study Selection: Studies were included for further review if they (1) reported on clinical diagnostic tests for posterior or posteroinferior instability of the glenohumeral joint, (2) assessed predictive clinical tests for posterior instability of the glenohumeral joint, and (3) were in English. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Data were extracted from the studies by 2 independent reviewers and included patient demographics and characteristics, index/reference test details (name and description of test), findings, and data available to calculate psychometric properties. Results: Five diagnostic and 2 predictive studies were selected for review. There was weak evidence for the use of the jerk test, Kim test, posterior impingement sign, and O’Brien test as stand-alone clinical tests for identifying posterior instability. Additionally, there was weak evidence to support the use of the painless jerk test and the hand squeeze sign as predictive tests for responders to conservative management. These findings are attributed to study design limitations, including small and/or nonrepresentative samples. Conclusion: Clustering of thorough history and physical examination findings, including the aforementioned tests, may identify those with posterior glenohumeral instability and assist in developing management strategies.

scholarly journals Clinical Diagnostic Tests versus Medial Branch Blocks for Adults with Persisting Cervical Zygapophyseal Joint Pain: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 70 (2) ◽  
pp. 179-187
Author(s):  
Kendra Usunier ◽  
Mark Hynes ◽  
James Michael Schuster ◽  
Annie Cornelio-Jin Suen ◽  
Jackie Sadi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Joint Pain ◽  
Meta Analysis ◽  
Medial Branch ◽  
Zygapophyseal Joint ◽  
Clinical Diagnostic

The validity and accuracy of clinical diagnostic tests used to detect labral pathology of the hip: A systematic review

2011 ◽  
Vol 16 (4) ◽  
pp. 318-326 ◽  
Author(s):  
Roanna M. Burgess ◽  
Alison Rushton ◽  
Chris Wright ◽  
Cathryn Daborn
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Clinical Diagnostic ◽  
Labral Pathology

Summarizing the evidence of the performance of diagnostic tests for Salmonella spp. in swine: A systematic review approach

2007 ◽  
Author(s):  
Wendy Wilkins ◽  
Andrijana Rajic ◽  
S. Parker ◽  
L. Wadell ◽  
J. Sanchez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Tests ◽  
Salmonella Spp

scholarly journals P014: Incidental findings in trauma whole-body CT scans: a systematic review

CJEM ◽  
2020 ◽  
Vol 22 (S1) ◽  
pp. S69-S69
Author(s):  
V. Tsang ◽  
K. Bao ◽  
J. Taylor
Keyword(s):  
Systematic Review ◽  
Incidental Findings ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Subsequent Treatment ◽  
Whole Body ◽  
Trauma Patients ◽  
Patient Demographics ◽  
Study Results

Introduction: Whole-body computed tomography scans (WBCT) are a mainstay in the work-up of polytrauma or multiple trauma patients in the emergency department. While incredibly useful for identifying traumatic injuries, WBCTs also reveal incidental findings in patients, some of which require further diagnostic testing and subsequent treatment. Although the presence of incidental findings in WBCTs have been well documented, there has been no systematic review conducted to organize and interpret findings, determine IF prevalence, and document strategies for best management. Methods: A systematic review was conducted using MEDLINE, PUBMED, and EMBASE. Specific journals and reference lists were hand-mined, and Google Scholar was used to find any additional papers. Data synthesis was performed to gather information on patient demographics, prevalence and type of incidental findings (IFs), and follow-up management was collected. All documents were independently assessed by the two reviewers for inclusion and any disagreements were resolved by consensus. Results: 1231 study results were identified, 59 abstracts, and 12 included in final review. A mean of 53.9% of patients had at least one IF identified, 31.5% had major findings, and 68.5% had minor findings. A mean of 2.7 IFs per patient was reported for articles that included number of total IFs. The mean age of patients included in the studies were 44 years old with IFs more common in older patients and men with more IFs than women. IFs were most commonly found in the abdominal/pelvic region followed by kidneys. Frequency of follow-up documentation was poor. The most common reported mechanisms of injury for patients included in the study were MVA and road traffic accidents (60.0%) followed by falls from >3m (23.2%). Conclusion: Although there is good documentation on the mechanism of injury, patient demographics, and type of IF, follow-up for IFs following acute trauma admission lacks documentation and follow-up and is an identified issue in patient management. There is great need for systematic protocols to address management of IFs in polytrauma patients.

scholarly journals Diagnosis of tuberculosis in wildlife: a systematic review

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Jobin Thomas ◽  
Ana Balseiro ◽  
Christian Gortázar ◽  
María A. Risalde
Keyword(s):  
Systematic Review ◽  
Test Performance ◽  
Diagnostic Tests ◽  
Large Scale ◽  
Diagnostic Techniques ◽  
Review Literature ◽  
Meat Industry ◽  
Post Mortem ◽  
Serological Tests ◽  
Ongoing Research

AbstractAnimal tuberculosis (TB) is a multi-host disease caused by members of the Mycobacterium tuberculosis complex (MTC). Due to its impact on economy, sanitary standards of milk and meat industry, public health and conservation, TB control is an actively ongoing research subject. Several wildlife species are involved in the maintenance and transmission of TB, so that new approaches to wildlife TB diagnosis have gained relevance in recent years. Diagnosis is a paramount step for screening, epidemiological investigation, as well as for ensuring the success of control strategies such as vaccination trials. This is the first review that systematically addresses data available for the diagnosis of TB in wildlife following the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The article also gives an overview of the factors related to host, environment, sampling, and diagnostic techniques which can affect test performance. After three screenings, 124 articles were considered for systematic review. Literature indicates that post-mortem examination and culture are useful methods for disease surveillance, but immunological diagnostic tests based on cellular and humoral immune response detection are gaining importance in wildlife TB diagnosis. Among them, serological tests are especially useful in wildlife because they are relatively inexpensive and easy to perform, facilitate large-scale surveillance and can be used both ante- and post-mortem. Currently available studies assessed test performance mostly in cervids, European badgers, wild suids and wild bovids. Research to improve diagnostic tests for wildlife TB diagnosis is still needed in order to reach accurate, rapid and cost-effective diagnostic techniques adequate to a broad range of target species and consistent over space and time to allow proper disease monitoring.

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