The genetics of sleep disorders in humans: Narcolepsy, restless legs syndrome, and obstructive sleep apnea syndrome

2009 ◽  
Vol 149A (11) ◽  
pp. 2612-2626 ◽  
Author(s):  
Emrah Caylak
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disorders ◽  
Obstructive Sleep Apnea Syndrome ◽  
Restless Legs Syndrome ◽  
Sleep Apnea Syndrome ◽  
Restless Legs ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Outcome of sleepiness and fatigue scores in obstructive sleep apnea syndrome patients with and without restless legs syndrome after nasal CPAP

2007 ◽  
Vol 65 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Raimundo Nonato Delgado Rodrigues ◽  
Aída Alexandra Alvim de Abreu e Silva Rodrigues ◽  
Riccardo Pratesi ◽  
Marília Miranda Fortes Gomes ◽  
Ana Maria Nogales Vasconcelos ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Restless Legs Syndrome ◽  
Sleep Apnea Syndrome ◽  
Restless Legs ◽  
Cpap Treatment ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
General Response

BACKGROUND & PURPOSE: The association of obstructive sleep apnea syndrome (OSAS) and restless legs syndrome (RLS) has been reported in the literature for many years. Both conditions may be responsible for fatigue and somnolence complaints secondary to nocturnal sleep disruption. The primary concern of this study is to evaluate the outcome of fatigue and daytime sleepiness symptoms at baseline and after continuous positive air pressure (CPAP) treatment in OSAS patients with and without RLS. METHOD: A prospective and comparative study between a group of 13 patients with OSAS and a group of 17 patients with OSAS+RLS. Laboratory blood tests and polysomnography were performed at baseline. The Epworth Sleepiness Scale (ESS) and the Pichot’s questionnaire of fatigue/depression (PIC) were applied before and after 3 months of CPAP treatment. Results were compared. RESULTS: No significant differences were found on PSG and laboratory results at baseline. Both groups had similar ESS and PIC scores at baseline (p=0.73 and 0.08, respectively). After n-CPAP, OSAS+RLS patients showed higher ESS and PIC scores (p=0.017 and 0.03, respectively). CONCLUSIONS: Despite a favorable general response, n-CPAP seemed less effective in treating fatigue and sleepiness in the OSAS+RLS group.

scholarly journals Prevalence of Obstructive Sleep Apnea Syndrome: A Single-Center Retrospective Study

2021 ◽  
Vol 18 (19) ◽  
pp. 10277
Author(s):  
Manlio Santilli ◽  
Eugenio Manciocchi ◽  
Gianmaria D’Addazio ◽  
Erica Di Maria ◽  
Michele D’Attilio ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disorders ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Single Center ◽  
Obstructive Sleep ◽  
Sleep Breathing Disorder ◽  
Patients At Risk ◽  
Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a sleep breathing disorder that often remains undiagnosed and untreated. OSAS prevalence is increasing exponentially. Starting on the dentist’s role as an epidemiological and diagnostic “sentinel”, the purpose of this study was to assess the prevalence of OSAS. The clinical diaries of 4659 patients were reviewed through a single-center retrospective analytic study. Descriptive statistical analysis was performed. Only 0.26% of patients reported to suffer from sleep apnea and were then diagnosed with OSAS. It was found that, out of 4487 patients, 678 suffered from hypertension (14.80%), 188 from gastro-esophageal-reflux-disease (GERD = 4.10%) and 484 from gastritis (10.78%). These results could be related to a difficult diagnosis of OSAS and to the absence of a dedicated section on sleep disorders in medical records. Therefore, the introduction of a question dedicated to sleep disorders, the administration of questionnaires (such as the STOP-BANG questionnaire) for early diagnosis, a multidisciplinary approach and pneumological examination could support the dentist in identifying patients at risk of OSAS.

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