DiGeorge anomaly in a patient with isochromosome 18p born to a diabetic mother

2005 ◽  
Vol 138A (2) ◽  
pp. 155-159 ◽  
Author(s):  
Ralph J. DeBerardinis ◽  
Livija Medne ◽  
Nancy B. Spinner ◽  
Elaine H. Zackai
Keyword(s):  
Diabetic Mother ◽  
Isochromosome 18P ◽  
Digeorge Anomaly

Fetal and neonatal metabolism in the pup of a canine diabetic mother. Fasting circulating fuels and neonatal glucose turnover

Diabetes ◽  
1983 ◽  
Vol 32 (4) ◽  
pp. 352-359 ◽  
Author(s):  
R. M. Kliegman ◽  
E. L. Miettinen ◽  
K. Y. Tserng
Keyword(s):  
Diabetic Mother ◽  
Glucose Turnover

The DiGeorge anomaly as a developmental field defect

1986 ◽  
Vol 25 (S2) ◽  
pp. 113-127 ◽  
Author(s):  
Edward J. Lammer ◽  
John M. Opitz ◽  
James F. Reynolds
Keyword(s):  
Digeorge Anomaly ◽  
Field Defect

Hypertrophic Obstructive Cardiomyopathy in an Infant of a Diabetic Mother

ASAIO Journal ◽  
1998 ◽  
Vol 44 (6) ◽  
pp. 845-847 ◽  
Author(s):  
Brad Robinson ◽  
Eshagh Eshaghpour ◽  
Stanford Ewing ◽  
Stephen Baumgart
Keyword(s):  
Hypertrophic Obstructive Cardiomyopathy ◽  
Diabetic Mother

Trisomy 18 caused by isochromosome 18p and 18q formation: Is there a milder phenotype?

2010 ◽  
Vol 155 (1) ◽  
pp. 225-227
Author(s):  
Giuseppe Maria Maruotti ◽  
Floriana Fabbrini ◽  
Raffaele Napolitano ◽  
Rita Genesio ◽  
Anna Conti ◽  
...  
Keyword(s):  
Trisomy 18 ◽  
Isochromosome 18P

TESTICULAR CHANGES IN INFANT OF DIABETIC MOTHER

The Lancet ◽  
1962 ◽  
Vol 279 (7241) ◽  
pp. 1243
Author(s):  
F. Geoghegan ◽  
M.I. Drury
Keyword(s):  
Diabetic Mother ◽  
Infant Of Diabetic Mother

Co-occurrence of mosaic supernumerary isochromosome 18p and intermittent 2q13 deletions in a child with multiple congenital anomalies

Gene ◽  
2015 ◽  
Vol 559 (1) ◽  
pp. 94-98 ◽  
Author(s):  
Sushil Kumar Jaiswal ◽  
Ashok Kumar ◽  
Akhtar Ali ◽  
Amit Kumar Rai
Keyword(s):  
Congenital Anomalies ◽  
Multiple Congenital Anomalies ◽  
Isochromosome 18P

scholarly journals Adverse perinatal outcome in diabetic mother treated with oral hypoglycemic agents vs. insulin

2017 ◽  
Vol 6 (6) ◽  
pp. 2252
Author(s):  
Leena Das ◽  
Bijay Kumar Meher ◽  
Sagar Parida ◽  
Deepti Damayanty Pradhan ◽  
Lucy Das ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Educational Background ◽  
Diabetic Mother ◽  
Hypoglycemic Agents ◽  
Care Hospital ◽  
Oral Hypoglycemic Agents ◽  
Significant Difference

Background: Insulin has been the primary mode of therapy in diabetic mother for glycemic control as oral hypoglycemic agents (OHA) were initially thought to have teratogenic effect. Recent data supports the use of certain OHA; this study was designed to compare the perinatal outcomes in infants born to diabetic mother treated with insulin vs. oral hypoglycemic agents and to find out the relation of adverse perinatal events to glycemic control in both groups.Methods: This prospective observational study was conducted in a tertiary care hospital. 108 neonates born to diabetic mother between October 2014 to September 2016 were taken for study immediately after delivery after excluding the mothers who were treated with lifestyle modification and/or dietary modification alone only. 60 mothers had received insulin and 48 OHA for glycaemic control. Glycemic control was assessed by HbA1C estimation on the day of delivery. The infants were followed up in neonatal care unit for perinatal complications. Main outcome measure(s): birth weight, gestational age, respiratory problems, birth injury, birth asphyxia, congenital anomalies, hypoglycemia, hypocalcaemia, hyperbillirubinemia.Results: Out of 108 infants, 27 were born to pregestational and 81 to gestational diabetic mothers. 60(55.5%) were treated with insulin and rest with OHA, 53(49.1%) had optimal glycemic control. Both the groups had similar glycemic control in the third trimester. None of the perinatal outcomes showed significant difference between insulin and OHA group except neonatal hyperbillirubinemia. (p=0.013, RR=8 and OR=0.106). Within the optimal glycemic control (HbA1C <8), LGA has significant association with the insulin group than OHA (p=0.012, RR=2.217 and OR=4.2018).Conclusions: As compared to insulin, oral hypoglycemic agents have similar glycemic control and no adverse perinatal outcomes and can be used in pregnant mothers with diabetes mellitus from poor socioeconomic and educational background for its low cost and better patient compliance. Within the glycemic control, maternal treatment with insulin showed significant difference in LGA compared to OHA which needs further studies for validation.

Sign in / Sign up

Export Citation Format

Share Document