Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22

2004 ◽  
Vol 130A (1) ◽  
pp. 37-39 ◽  
Author(s):  
Adam Cuker ◽  
Matthew W. State ◽  
Robert A. King ◽  
Nicole Davis ◽  
David C. Ward
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Obsessive Compulsive ◽  
Candidate Locus ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Chronic Tic Disorder

PROLACTIN IN CHILDHOOD OBSESSIVE-COMPULSIVE DISORDER: CLINICAL CORRELATES AND RESPONSE TO CLOMIPRAMINE

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 992-992
Author(s):  
Gregory L. Hanna ◽  
James T. MCCracken ◽  
Dennis P. Cantwell
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Serotonergic Receptors ◽  
Duration Of Illness ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Clomipramine Treatment

Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.

Obsessive-compulsive disorder in youth with and without a chronic tic disorder

2008 ◽  
Vol 25 (9) ◽  
pp. 761-767 ◽  
Author(s):  
Eric A. Storch ◽  
David Stigge-Kaufman ◽  
Wendi E. Marien ◽  
Muhammad Sajid ◽  
Marni L. Jacob ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Chronic Tic Disorder

Obsessive–Compulsive Disorder with and without a Chronic Tic Disorder

1994 ◽  
Vol 164 (4) ◽  
pp. 469-473 ◽  
Author(s):  
Jacob C. Holzer ◽  
Christopher J. McDougle ◽  
Beth K. Boyarsky ◽  
Lawrence H. Price ◽  
Wayne K. Goodman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Function Analysis ◽  
Symptom Checklist ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Lifetime History ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Age And Sex

The phenomenological features of 35 obsessive–compulsive disorder (OCD) patients with a lifetime history of tics were compared to 35 age- and sex-matched OCD patients without tics. Seven categories of obsessions and nine categories of compulsions were determined using the symptom checklist of the Yale–Brown Obsessive–Compulsive Scale (YBOCS). Discriminant function analysis revealed that, compared to their counterparts without tics, OCD patients with tics had more touching, tapping, rubbing, blinking and staring rituals, and fewer cleaning rituals, but did not differ on obsessions. These preliminary findings suggest that the types of compulsions present may help to discriminate between two putative subgroups of OCD, i.e. those with and without tics.

scholarly journals WISC-IV performance of children with Chronic Tic Disorder, Obsessive–Compulsive Disorder and Attention-Deficit/Hyperactivity Disorder: results from a German clinical study

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sina Wanderer ◽  
Veit Roessner ◽  
Anja Strobel ◽  
Julia Martini
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obsessive Compulsive Disorder ◽  
Attention Deficit ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Children With Adhd ◽  
Compulsive Disorder ◽  
Hyperactivity Disorder ◽  
Chronic Tic Disorder ◽  
New Findings

Abstract Background Chronic Tic Disorder (CTD), Obsessive–Compulsive Disorder (OCD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex neuropsychiatric disorders that frequently co-occur. The aim of this study was to examine WISC-IV performance of a clinical cohort of children with CTD, OCD and/or ADHD. Methods N = 185 children aged 6 to 17 years from Germany with CTD, OCD and/or ADHD were examined with the WISC-IV that comprises four index scores (VCI: Verbal Comprehension Index, PRI: Perceptual Reasoning Index, WMI: Working Memory Index, PSI: Processing Speed Index) and a Full Scale Intelligence Quotient (FSIQ). WISC-IV profiles of children with CTD-only, OCD-only, ADHD-only, CTD+ADHD, CTD+OCD and CTD+OCD+ADHD were compared with the WISC-IV norm (N = 1650, M = 100 and SD = 15) and among each other. Results Unpaired t-tests revealed that children with ADHD-only showed significant lower PSI scores, whereas children with CTD-only and OCD-only had significant higher VCI scores as compared to the German WISC-IV norm. One-way ANOVA revealed that children with ADHD-only showed significant lower WMI scores as compared to children with CTD+OCD. Conclusions We were able to confirm previous evidence on WISC-IV profiles in ADHD in a German clinical sample and contribute new findings on cognitive performance in children with (non-)comorbid CTD and OCD that have to be seen in light of the study’s limitations.

Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder

2001 ◽  
Vol 120 (1-2) ◽  
pp. 146-151 ◽  
Author(s):  
Tanya K Murphy ◽  
Neal Benson ◽  
Annette Zaytoun ◽  
Mark Yang ◽  
Raul Braylan ◽  
...  
Keyword(s):  
B Cells ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Chronic Tic Disorder

Obsessive-Compulsive Disorder and Tic Disorder/Tourette Syndrome

2021 ◽  
pp. 41-60
Author(s):  
Ashley M. Shaw ◽  
Elizabeth R. Halliday
Keyword(s):  
Randomized Controlled Trial ◽  
Emotional Disorders ◽  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Controlled Trial ◽  
Habit Reversal ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Transdiagnostic Treatment ◽  
Compulsive Disorder

The Unified Protocols for Transdiagnostic Treatment of Emotional Disorders in Children and Adolescents (UP-C/A) have clinical relevance for youth with obsessive-compulsive disorder (OCD) and Tourette syndrome, particularly when comorbid anxiety and depression are present. Within this population, the UP-C/A can be applied either as standalone interventions or in conjunction with exposure and response prevention or habit reversal techniques. However, their efficacy and utility in these populations have never been examined in a randomized controlled trial. This chapter outlines recommendations for how to apply the UP-C/A to youth with OCD and related disorders. For example, applying module content in a flexible order is recommended, such as generating a list of emotional behaviors early in treatment, and checking in about opposite actions throughout treatment. Introducing nonjudgmental awareness and exposures early in treatment is also recommended.

scholarly journals Pharmacotherapy for tics in adult patients with Tourette syndrome and other tic disorders

2020 ◽  
Vol 41 (7) ◽  
pp. 1923-1926
Author(s):  
James Badenoch ◽  
Andrea E. Cavanna
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Group Analysis ◽  
Adult Patients ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Hyperactivity Disorder ◽  
The Uk

Abstract Background Tourette syndrome (TS) and persistent motor/vocal tic disorders are neurodevelopmental conditions characterised by the chronic presence of motor and/or vocal tics. Patients with TS often present with co-morbid disorders, especially attention-deficit and hyperactivity disorder (which tends to improve after childhood), and obsessive-compulsive disorder (which can persist in adulthood). We set out to explore pharmacotherapy for tics in adult patients with TS and persistent motor/vocal tic disorders, as well as its relationship with the presence of co-morbid conditions. Methods We retrospectively reviewed the clinical characteristics and pharmacotherapy of 192 adult patients with TS (n = 187), persistent motor tic disorder (n = 3) and persistent vocal tic disorder (n = 2) attending a specialist clinic in the UK. Results Anti-dopaminergic medications (n = 65) and alpha-2-agonists (n = 50) were the most commonly prescribed pharmacotherapy for tic management. A sub-group analysis revealed that co-morbid obsessive-compulsive disorder and sub-threshold obsessive-compulsive behaviours were significantly more common in patients treated with anti-dopaminergic medications than patients taking alpha-2-agonists (p = 0.013 and p = 0.047, respectively). Conclusions The use of pharmacotherapy options for tic management observed at a specialist clinic for adults with TS reflects guideline recommendations. We found that the presence of co-morbid obsessive-compulsive disorder/behaviours correlates with the choice of anti-dopaminergic medications over alpha-2-agonists, in line with available evidence on the efficacy of anti-dopaminergic medications for the treatment of specific tic–related behavioural symptoms.

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