A novel mutation of tumor necrosis factor receptor alpha type 1 associated with TRAPS and amyloidosis

2004 ◽  
Vol 128A (3) ◽  
pp. 331-331 ◽  
Author(s):  
E. Nilufer Broeders ◽  
Daniel Abramowicz ◽  
Marc J. Abramowicz ◽  
Jasmine Parma
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Novel Mutation ◽  
Tumor Necrosis Factor Receptor ◽  
Receptor Alpha ◽  
Factor Receptor Alpha ◽  
Alpha Type ◽  
Necrosis Factor

The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement

2007 ◽  
Vol 86 (11) ◽  
pp. 1089-1094 ◽  
Author(s):  
I. Andrade ◽  
T.A. Silva ◽  
G.A.B. Silva ◽  
A.L. Teixeira ◽  
M.M. Teixeira
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tooth Movement ◽  
Tumor Necrosis Factor Receptor ◽  
Orthodontic Tooth Movement ◽  
Receptor Type ◽  
Periodontal Tissues ◽  
Tnf Α ◽  
Necrosis Factor

Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)-α plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and p55-deficient mice (p55−/−). Levels of TNF-α and 2 chemokines (MCP-1/CCL2, RANTES/CCL5) were evaluated in periodontal tissues. A significant increase in CCL2 and TNF-α was observed in both groups after 12 hrs of mechanical loading. However, CCL5 levels remained unchanged in p55−/− mice at this time-point. The number of TRAP-positive osteoclasts in p55−/− mice was significantly lower than that in WT mice. Also, there was a significantly smaller rate of tooth movement in p55−/− mice. Analysis of our data suggests that the TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.

scholarly journals Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor

Hepatology ◽  
1998 ◽  
Vol 28 (4) ◽  
pp. 959-970 ◽  
Author(s):  
Yasuhiro Yamada ◽  
Eric M. Webber ◽  
Irina Kirillova ◽  
Jacques J. Peschon ◽  
Nelson Fausto
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Regeneration ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Necrosis Factor

scholarly journals Role of SODD in Regulation of Tumor Necrosis Factor Responses

2003 ◽  
Vol 23 (11) ◽  
pp. 4026-4033 ◽  
Author(s):  
Hidetoshi Takada ◽  
Nien-Jung Chen ◽  
Christine Mirtsos ◽  
Shinobu Suzuki ◽  
Nobutaka Suzuki ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Signaling Proteins ◽  
Ligand Stimulation ◽  
Cytotoxic Responses ◽  
Necrosis Factor

ABSTRACT Signaling from tumor necrosis factor receptor type 1 (TNFR1) can elicit potent inflammatory and cytotoxic responses that need to be properly regulated. It was suggested that the silencer of death domains (SODD) protein constitutively associates intracellularly with TNFR1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR1 molecules that are juxtaposed in the absence of ligand stimulation. In this study, we demonstrate that mice lacking SODD produce larger amounts of cytokines in response to in vivo TNF challenge. SODD-deficient macrophages and embryonic fibroblasts also show altered responses to TNF. TNF-induced activation of NF-κB is accelerated in SODD-deficient cells, but TNF-induced c-Jun N-terminal kinase activity is slightly repressed. Interestingly, the apoptotic arm of TNF signaling is not hyperresponsive in the SODD-deficient cells. Together, these results suggest that SODD is critical for the regulation of TNF signaling.

scholarly journals Tumor Necrosis Factor Induces Tumor Necrosis via Tumor Necrosis Factor Receptor Type 1-Expressing Endothelial Cells of the Tumor Vasculature

2000 ◽  
Vol 156 (4) ◽  
pp. 1171-1176 ◽  
Author(s):  
Benjamin Stoelcker ◽  
Brigitte Ruhland ◽  
Thomas Hehlgans ◽  
Horst Bluethmann ◽  
Thomas Luther ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Tumor Vasculature ◽  
Receptor Type ◽  
Necrosis Factor

Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor

1999 ◽  
Vol 11 (1) ◽  
pp. 51 ◽  
Author(s):  
Yasuhiro Yamada ◽  
Eric M. Webber ◽  
Irina Kirillova ◽  
Jaques J. Peschon ◽  
Nelson Fausto
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Regeneration ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Necrosis Factor
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