Lack of association between the tryptophan hydroxylase gene A218C polymorphism and attention-deficit hyperactivity disorder in Chinese Han population

2001 ◽  
Vol 105 (6) ◽  
pp. 485-488 ◽  
Author(s):  
Guomei Tang ◽  
Daming Ren ◽  
Rener Xin ◽  
Yiping Qian ◽  
Dongyang Wang ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Tryptophan Hydroxylase ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Hyperactivity Disorder ◽  
Hydroxylase Gene

scholarly journals Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, and TPH2-703G/T (rs4570625) genotype

2020 ◽  
Vol 32 (5) ◽  
pp. 247-256 ◽  
Author(s):  
Aleksander Pulver ◽  
Evelyn Kiive ◽  
Jaanus Harro
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Tryptophan Hydroxylase ◽  
Negative Relationship ◽  
Reward Sensitivity ◽  
Self Report ◽  
Measurement Scale ◽  
Health Study ◽  
Affective Neuroscience ◽  
Hyperactivity Disorder

AbstractObjective:Reward sensitivity is an increasingly used construct in psychiatry, yet its possible inner structure and relationship with other affective variables are not well known.Methods:A reward sensitivity measurement scale was constructed on the basis of large item pool collected from birth cohort representative samples (the Estonian Children Personality Behaviour and Health Study; original n = 1238). Affective Neuroscience Personality Scale (ANPS) and the Adult Attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS) were administered in young adulthood. A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped.Results:Reward sensitivity consisted of two orthogonal components, operationally defined as Openness to Rewards and Insatiability by Reward, that respectively characterise the striving towards multiple rewards and the strong pursuit and fixation to a particular reward. While SEEKING and PLAY (and to lower extent CARE) of the ANPS co-varied with Openness to Rewards, FEAR, SADNESS, and ANGER were related to Insatiability by Reward. The total score of ASRS was moderately correlated with Insatiability by Reward, while the association with Openness to Rewards was negligible. However, ASRS Inattention had some negative relationship with the Social Experience facet of Openness to Rewards. The T/T homozygotes for the TPH2 promoter polymorphism had lower Insatiability by Reward but not Openness to Rewards.Conclusions:Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention, and hyperactivity as well as to TPH2 genotype.

Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population

2015 ◽  
Vol 600 ◽  
pp. 98-103 ◽  
Author(s):  
Xiaoquan Wang ◽  
Zusen Wang ◽  
Yanfeng Wu ◽  
Zhenghua Hou ◽  
Yonggui Yuan ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Late Onset ◽  
Chinese Han Population ◽  
Tryptophan Hydroxylase 2 ◽  
Chinese Han ◽  
Han Population
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