Could acrocallosal syndrome and Greig syndrome affect the same developmental gene?

Judith G. Hall

doi:10.1002/ajmg.1320360331

The acrocallosal syndrome and Greig syndrome are not allelic disorders.

Journal of Medical Genetics ◽

10.1136/jmg.29.9.635 ◽

1992 ◽

Vol 29 (9) ◽

pp. 635-637 ◽

Cited By ~ 13

Author(s):

L A Brueton ◽

K A Chotai ◽

L van Herwerden ◽

A Schinzel ◽

R M Winter

Keyword(s):

Acrocallosal Syndrome ◽

Greig Syndrome ◽

Allelic Disorders

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Faculty Opinions recommendation of The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020588.235489 ◽

2004 ◽

Author(s):

Beth Lazazzera

Keyword(s):

Streptomyces Coelicolor ◽

Developmental Gene

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Developmental Gene Markers in Tumor Pathogenesis and Progression

Disease Markers ◽

10.1155/2019/5462562 ◽

2019 ◽

Vol 2019 ◽

pp. 1-2

Author(s):

Monica Cantile ◽

Giuseppe Palmieri ◽

Gerardo Botti

Keyword(s):

Developmental Gene ◽

Gene Markers ◽

Tumor Pathogenesis

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Maternal Style Selectively Shapes Amygdalar Development and Social Behavior in Rats Genetically Prone to High Anxiety

Developmental Neuroscience ◽

10.1159/000374108 ◽

2015 ◽

Vol 37 (3) ◽

pp. 203-214 ◽

Cited By ~ 14

Author(s):

Joshua L. Cohen ◽

Matthew E. Glover ◽

Phyllis C. Pugh ◽

Andrew D. Fant ◽

Rebecca K. Simmons ◽

...

Keyword(s):

Gene Expression ◽

Psychological Health ◽

Early Life ◽

Developmental Trajectory ◽

Emotional Behavior ◽

Developmental Gene ◽

Developmental Gene Expression ◽

Maternal Style ◽

Anxiety Depression ◽

Cross Fostering

The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament and environmental reactivity. We selectively bred rats for high versus low behavioral response to novelty and found that high-reactive (bred high-responder, bHR) rats displayed greater risk-taking, impulsivity and aggression relative to low-reactive (bred low-responder, bLR) rats, which showed high levels of anxiety/depression-like behavior and certain stress vulnerability. The bHR/bLR traits are heritable, but prior work revealed bHR/bLR maternal style differences, with bLR dams showing more maternal attention than bHRs. The present study implemented a cross-fostering paradigm to examine the contribution of maternal behavior to the brain development and emotional behavior of bLR offspring. bLR offspring were reared by biological bLR mothers or fostered to a bLR or bHR mother and then evaluated to determine the effects on the following: (1) developmental gene expression in the hippocampus and amygdala and (2) adult anxiety/depression-like behavior. Genome-wide expression profiling showed that cross-fostering bLR rats to bHR mothers shifted developmental gene expression in the amygdala (but not hippocampus), reduced adult anxiety and enhanced social interaction. Our findings illustrate how an early-life manipulation such as cross-fostering changes the brain's developmental trajectory and ultimately impacts adult behavior. Moreover, while earlier studies highlighted hippocampal differences contributing to the bHR/bLR phenotypes, our results point to a role of the amygdala as well. Future work will pursue genetic and cellular mechanisms within the amygdala that contribute to bHR/bLR behavior either at baseline or following environmental manipulations.

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Genome sequences reveal global dispersal routes and suggest convergent genetic adaptations in seahorse evolution

Nature Communications ◽

10.1038/s41467-021-21379-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Chunyan Li ◽

Melisa Olave ◽

Yali Hou ◽

Geng Qin ◽

Ralf F. Schneider ◽

...

Keyword(s):

Coastal Waters ◽

Genetic Basis ◽

De Novo ◽

Ocean Currents ◽

Rapid Adaptation ◽

Developmental Gene ◽

De Novo Genome Assembly ◽

Biogeographic Patterns ◽

Hippocampus Erectus ◽

New Habitats

AbstractSeahorses have a circum-global distribution in tropical to temperate coastal waters. Yet, seahorses show many adaptations for a sedentary, cryptic lifestyle: they require specific habitats, such as seagrass, kelp or coral reefs, lack pelvic and caudal fins, and give birth to directly developed offspring without pronounced pelagic larval stage, rendering long-range dispersal by conventional means inefficient. Here we investigate seahorses’ worldwide dispersal and biogeographic patterns based on a de novo genome assembly of Hippocampus erectus as well as 358 re-sequenced genomes from 21 species. Seahorses evolved in the late Oligocene and subsequent circum-global colonization routes are identified and linked to changing dynamics in ocean currents and paleo-temporal seaway openings. Furthermore, the genetic basis of the recurring “bony spines” adaptive phenotype is linked to independent substitutions in a key developmental gene. Analyses thus suggest that rafting via ocean currents compensates for poor dispersal and rapid adaptation facilitates colonizing new habitats.

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act Operon Control of Developmental Gene Expression in Myxococcus xanthus

Journal of Bacteriology ◽

10.1128/jb.184.4.1172-1179.2002 ◽

2002 ◽

Vol 184 (4) ◽

pp. 1172-1179 ◽

Cited By ~ 32

Author(s):

Thomas M. A. Gronewold ◽

Dale Kaiser

Keyword(s):

Fruiting Body ◽

Myxococcus Xanthus ◽

The Other ◽

Loss Of Function ◽

Wild Type ◽

Developmental Gene ◽

Developmental Gene Expression ◽

Mutant Strains ◽

Genes Encoding ◽

Signal Production

ABSTRACT Cell-bound C-signal guides the building of a fruiting body and triggers the differentiation of myxospores. Earlier work has shown that transcription of the csgA gene, which encodes the C-signal, is directed by four genes of the act operon. To see how expression of the genes encoding components of the aggregation and sporulation processes depends on C-signaling, mutants with loss-of-function mutations in each of the act genes were investigated. These mutations were found to have no effect on genes that are normally expressed up to 3 h into development and are C-signal independent. Neither the time of first expression nor the rate of expression increase was changed in actA, actB, actC, or actD mutant strains. Also, there was no effect on A-signal production, which normally starts before 3 h. By contrast, the null act mutants have striking defects in C-signal production. These mutations changed the expression of four gene reporters that are related to aggregation and sporulation and are expressed at 6 h or later in development. The actA and actB null mutations substantially decreased the expression of all these reporters. The other act null mutations caused either premature expression to wild-type levels (actC) or delayed expression (actD), which ultimately rose to wild-type levels. The pattern of effects on these reporters shows how the C-signal differentially regulates the steps that together build a fruiting body and differentiate spores within it.

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