A cluster of hypersensitivity pneumonitis associated with exposure to metalworking fluids

2021 ◽  
Author(s):  
Aaron W. Tustin ◽  
Ryan Cooney ◽  
Glenn E. Lamson ◽  
Michael J. Hodgson
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

scholarly journals Factors Influencing the Microbial Composition of Metalworking Fluids and Potential Implications for Machine Operator's Lung

2011 ◽  
Vol 78 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Jean-Benjamin Murat ◽  
Frédéric Grenouillet ◽  
Gabriel Reboux ◽  
Emmanuelle Penven ◽  
Adam Batchili ◽  
...  
Keyword(s):  
Metal Cutting ◽  
Hypersensitivity Pneumonitis ◽  
Environmental Parameters ◽  
Metalworking Fluids ◽  
Microbial Composition ◽  
Gram Positive ◽  
Gram Negative ◽  
Content Type ◽  
Kinetics Of

ABSTRACTHypersensitivity pneumonitis, also known as “machine operator's lung” (MOL), has been related to microorganisms growing in metalworking fluids (MWFs), especiallyMycobacterium immunogenum. We aimed to (i) describe the microbiological contamination of MWFs and (ii) look for chemical, physical, and environmental parameters associated with variations in microbiological profiles. We microbiologically analyzed 180 MWF samples from nonautomotive plants (e.g., screw-machining or metal-cutting plants) in the Franche-Comté region in eastern France and 165 samples from three French automotive plants in which cases of MOL had been proven. Our results revealed two types of microbial biomes: the first was from the nonautomotive industry, showed predominantly Gram-negative rods (GNR), and was associated with a low risk of MOL, and the second came from the automotive industry that was affected by cases of MOL and showed predominantly Gram-positive rods (GPR). Traces ofM. immunogenumwere sporadically detected in the first type, while it was highly prevalent in the automotive sector, with up to 38% of samples testing positive. The use of chromium, nickel, or iron was associated with growth of Gram-negative rods; conversely, growth of Gram-positive rods was associated with the absence of these metals. Synthetic MWFs were more frequently sterile than emulsions. Vegetable oil-based emulsions were associated with GNR, while mineral ones were associated with GPR. Our results suggest that metal types and the nature of MWF play a part in MWF contamination, and this work shall be followed by furtherin vitrosimulation experiments on the kinetics of microbial populations, focusing on the phenomena of inhibition and synergy.

scholarly journals Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria

2011 ◽  
Vol 38 (2) ◽  
pp. 486-487 ◽  
Author(s):  
C. M. Barber ◽  
C. Burton ◽  
E. Robinson ◽  
B. Crook ◽  
G. Evans ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

Hypersensitivity pneumonitis in a cystic fibrosis patient

2019 ◽  
Author(s):  
A P Bellanger ◽  
H Morisse-Pradier ◽  
G Reboux ◽  
E Scherer ◽  
S Pramil ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Cystic Fibrosis Patient ◽  
Pulmonary Disease ◽  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids ◽  
Aetiological Agent ◽  
Pseudomonas Oleovorans ◽  
Inflammatory Lung Disease

Abstract Hypersensitivity pneumonitis (HP) is a chronic inflammatory lung disease caused by repeated inhalation of antigenic substances. We present a case of metalworking fluids (MWFs)-HP sensitized to Pseudomonas oleovorans in a cystic fibrosis patient. This case illustrates that HP diagnosis remains challenging, especially in patients with another pulmonary disease, and that serodiagnosis contributes to identifying the precise microorganism involved. It also demonstrates that P. oleovorans is an important secondary aetiological agent in MWF-HP, less known than Mycobacterium immunogenum.

scholarly journals Presence of a Single Genotype of the Newly Described Species Mycobacterium immunogenum in Industrial Metalworking Fluids Associated with Hypersensitivity Pneumonitis

2002 ◽  
Vol 68 (11) ◽  
pp. 5580-5584 ◽  
Author(s):  
Richard J. Wallace, ◽  
Yansheng Zhang ◽  
Rebecca W. Wilson ◽  
Linda Mann ◽  
Harold Rossmoore
Keyword(s):  
Genomic Dna ◽  
Hypersensitivity Pneumonitis ◽  
The United States ◽  
Clinical Isolates ◽  
Metalworking Fluids ◽  
Enzyme Analysis ◽  
Restriction Enzyme Analysis ◽  
Clinical Patient ◽  
Industrial Sites ◽  
Single Genotype

ABSTRACT Outbreaks of hypersensitivity pneumonitis (HP) among industrial metal-grinding machinists working with water-based metalworking fluids (MWF) have frequently been associated with high levels of mycobacteria in the MWF, but little is known about these organisms. We collected 107 MWF isolates of mycobacteria from multiple industrial sites where HP had been diagnosed and identified them to the species level by a molecular method (PCR restriction enzyme analysis [PRA]). Their genomic DNA restriction fragment length polymorphism (RFLP) patterns, as determined by pulsed-field gel electrophoresis (PFGE), were compared to those of 15 clinical (patient) isolates of the recently described rapidly growing mycobacterial species Mycobacterium immunogenum. A total of 102 of 107 (95%) MWF isolates (from 10 industrial sites within the United States and Canada) were identified as M. immunogenum and gave PRA patterns identical to those of the clinical isolates. Using genomic DNA, PFGE was performed on 80 of these isolates. According to RFLP analysis using the restriction enzymes DraI and XbaI, 78 of 80 (98%) of the MWF isolates represented a single clone. In contrast, none of the 15 clinical isolates had genetic patterns the same as or closely related to those of any of the others. Given the genomic heterogeneity of clinical isolates of M. immunogenum, the finding that a single genotype was present at all industrial sites is remarkable. This suggests that this genotype possesses unusual features that may relate to its virulence and its potential etiologic role in HP and/or to its resistance to biocides frequently used in MWF.

scholarly journals Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria

2011 ◽  
Vol 38 (2) ◽  
pp. 487-488
Author(s):  
G. Reboux ◽  
I. Tillie-Leblond ◽  
F. Grenouillet ◽  
S. Roussel ◽  
L. Millon
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

scholarly journals Hypersensitivity pneumonitis in workers exposed to metalworking fluids

2014 ◽  
Vol 57 (8) ◽  
pp. 872-880 ◽  
Author(s):  
Christopher M. Barber ◽  
Clare M. Burton ◽  
David J. Hendrick ◽  
C Anthony C. Pickering ◽  
Alastair S. Robertson ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

Hypersensitivity Pneumonitis due to Metalworking Fluids: How to Find the Antigens

2013 ◽  
pp. 335-340 ◽  
Author(s):  
R. Merget ◽  
I. Sander ◽  
V. van Kampen ◽  
M. Raulf-Heimsoth ◽  
T. Rabente ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

scholarly journals Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria

2010 ◽  
Vol 37 (3) ◽  
pp. 640-647 ◽  
Author(s):  
I. Tillie-Leblond ◽  
F. Grenouillet ◽  
G. Reboux ◽  
S. Roussel ◽  
B. Chouraki ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids
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