scholarly journals Lung function decline before and after treatment of World Trade Center associated obstructive airways disease with inhaled corticosteroids and long‐acting beta agonists

2021 ◽  
Author(s):  
David G. Goldfarb ◽  
Barbara Putman ◽  
Lies Lahousse ◽  
Rachel Zeig‐Owens ◽  
Brandon M. Vaeth ◽  
...  
Keyword(s):  
Lung Function ◽  
World Trade ◽  
Inhaled Corticosteroids ◽  
World Trade Center ◽  
Lung Function Decline ◽  
Beta Agonists ◽  
Before And After ◽  
Obstructive Airways Disease ◽  
Trade Center ◽  
Long Acting

scholarly journals Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers

2020 ◽  
Author(s):  
Xiaoyu Liu ◽  
Anthony P. Reeves ◽  
Katherine Antoniak ◽  
Raúl San José Estépar ◽  
John T. Doucette ◽  
...  
Keyword(s):  
Lung Function ◽  
World Trade ◽  
World Trade Center ◽  
Lung Function Decline ◽  
Quantitative Ct ◽  
Lung Density ◽  
Density Measurements ◽  
Trade Center

scholarly journals Metabolomics of World Trade Center-Lung Injury: a machine learning approach

2018 ◽  
Vol 5 (1) ◽  
pp. e000274 ◽  
Author(s):  
George Crowley ◽  
Sophia Kwon ◽  
Syed Hissam Haider ◽  
Erin J Caraher ◽  
Rachel Lam ◽  
...  
Keyword(s):  
Machine Learning ◽  
Lung Function ◽  
Lung Injury ◽  
World Trade ◽  
World Trade Center ◽  
Forced Expiratory Volume ◽  
Machine Learning Techniques ◽  
Maximal Class ◽  
Class Separation ◽  
Trade Center

IntroductionBiomarkers of metabolic syndrome expressed soon after World Trade Center (WTC) exposure predict development of WTC Lung Injury (WTC-LI). The metabolome remains an untapped resource with potential to comprehensively characterise many aspects of WTC-LI. This case–control study identified a clinically relevant, robust subset of metabolic contributors of WTC-LI through comprehensive high-dimensional metabolic profiling and integration of machine learning techniques.MethodsNever-smoking, male, WTC-exposed firefighters with normal pre-9/11 lung function were segregated by post-9/11 lung function. Cases of WTC-LI (forced expiratory volume in 1s <lower limit of normal, n=15) and controls (n=15) were identified from previous cohorts. The metabolome of serum drawn within 6 months of 9/11 was quantified. Machine learning was used for dimension reduction to identify metabolites associated with WTC-LI.Results580 metabolites qualified for random forests (RF) analysis to identify a refined metabolite profile that yielded maximal class separation. RF of the refined profile correctly classified subjects with a 93.3% estimated success rate. 5 clusters of metabolites emerged within the refined profile. Prominent subpathways include known mediators of lung disease such as sphingolipids (elevated in cases of WTC-LI), and branched-chain amino acids (reduced in cases of WTC-LI). Principal component analysis of the refined profile explained 68.3% of variance in five components, demonstrating class separation.ConclusionAnalysis of the metabolome of WTC-exposed 9/11 rescue workers has identified biologically plausible pathways associated with loss of lung function. Since metabolites are proximal markers of disease processes, metabolites could capture the complexity of past exposures and better inform treatment. These pathways warrant further mechanistic research.

Psychological Effects of Attack on the World Trade Center: Analysis before and after

2004 ◽  
Vol 94 (2) ◽  
pp. 587-606 ◽  
Author(s):  
W. Cody Wilson ◽  
Beth Spenciner Rosenthal
Keyword(s):  
Psychological Distress ◽  
World Trade ◽  
World Trade Center ◽  
Total Sample ◽  
Traumatic Experiences ◽  
World Trade Center Attack ◽  
Cross Sectional ◽  
The World ◽  
Before And After ◽  
Trade Center

Four different studies using a total sample of 711 from the same New York City student population tested a model that has emerged from previous research on disasters. The model suggests that postdisaster psychological distress is a function of exposure to the disaster, predisaster psychological distress, acute distress following the disaster, time elapsed between disaster and observation of distress, and additional traumatic experiences since the disaster. Although findings replicate those of previous cross-sectional studies regarding association of exposure and distress after the disaster, before and after studies did not detect an effect on postdisaster psychological distress of the World Trade Center attack. Great caution must be used in attributing elevated psychological distress observed postdisaster to the effects of the disaster.

scholarly journals Lung Function in Rescue Workers at the World Trade Center after 7 Years

2010 ◽  
Vol 362 (14) ◽  
pp. 1263-1272 ◽  
Author(s):  
Thomas K. Aldrich ◽  
Jackson Gustave ◽  
Charles B. Hall ◽  
Hillel W. Cohen ◽  
Mayris P. Webber ◽  
...  
Keyword(s):  
Lung Function ◽  
World Trade ◽  
World Trade Center ◽  
Rescue Workers ◽  
The World ◽  
Trade Center

scholarly journals Bronchial Reactivity and Lung Function After World Trade Center Exposure

CHEST Journal ◽  
2016 ◽  
Vol 150 (6) ◽  
pp. 1333-1340 ◽  
Author(s):  
Thomas K. Aldrich ◽  
Jessica Weakley ◽  
Sean Dhar ◽  
Charles B. Hall ◽  
Tesha Crosse ◽  
...  
Keyword(s):  
Lung Function ◽  
World Trade ◽  
World Trade Center ◽  
Bronchial Reactivity ◽  
Trade Center

scholarly journals Obstructive Airways Disease With Air Trapping Among Firefighters Exposed to World Trade Center Dust

CHEST Journal ◽  
2010 ◽  
Vol 137 (3) ◽  
pp. 566-574 ◽  
Author(s):  
Michael D. Weiden ◽  
Natalia Ferrier ◽  
Anna Nolan ◽  
William N. Rom ◽  
Ashley Comfort ◽  
...  
Keyword(s):  
World Trade ◽  
World Trade Center ◽  
Air Trapping ◽  
Obstructive Airways Disease ◽  
Trade Center
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