Significant relationship between the extent of pleural plaques and pulmonary asbestos body concentration in lung cancer patients with occupational asbestos exposure

2015 ◽  
Vol 58 (4) ◽  
pp. 444-455 ◽  
Author(s):  
Toshikazu Yusa ◽  
Kenzo Hiroshima ◽  
Fumikazu Sakai ◽  
Takumi Kishimoto ◽  
Kazuo Ohnishi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Significant Relationship ◽  
Asbestos Exposure ◽  
Lung Cancer Patients ◽  
Pleural Plaques ◽  
Asbestos Body ◽  
Body Concentration

scholarly journals Characteristics of asbestos fibers in lung tissue from occupational and environmental asbestos exposure of lung cancer patients in Busan, Korea

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hyun-Sung Jung ◽  
Eun-Kee Park ◽  
Jun-Seok Cha ◽  
Jae-Won Lee ◽  
Jong-Chun Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Lung Tissue ◽  
Asbestos Exposure ◽  
Coefficient Of Determination ◽  
Factors Affecting ◽  
Lung Cancer Patients ◽  
Asbestos Fibers ◽  
Significant Difference ◽  
Occupationally Exposed

AbstractThe Asbestos Injury Relief Act in Korea requires that asbestos exposure be assessed through clinical examination and chest computed tomography (CT). However, a more specific measurement of asbestos characteristics in the lung tissue may be appropriate. We aimed to investigate the asbestos burden and characterize asbestos fibers in patients with lung cancer and ultimately assess the relationship between occupational and environmental asbestos exposure and lung cancer in Korea. We evaluated 37 lung cancer patients (LCPs) from Busan. The factors affecting asbestos burden in LCPs were analyzed using a multiple regression analysis. History of asbestos exposure (environmental/occupational), male sex, and old age were the main factors affecting asbestos burden in lung tissues of LCPs. These factors had an approximate 37% adjusted coefficient of determination. There was a significant difference in the length of asbestos fibers (4.06–37.6 µm vs. 4.26–91.7 µm) and aspect ratio (4.5–151.9 vs. 5.6–735.6) between those who were occupationally exposed to asbestos and those who were environmentally exposed (P < 0.01). Therefore, both environmental/occupational exposure to asbestos should be strongly managed to reduce the risk of lung cancer, and exposure should be assessed according to the characteristics of asbestos fibers in the lung tissue.

Role of occupational asbestos exposure in Hungarian lung cancer patients

2000 ◽  
Vol 73 (8) ◽  
pp. 555-560 ◽  
Author(s):  
A. M�ndi ◽  
M. Posgay ◽  
P. Vad�sz ◽  
K. Major ◽  
K. R�delsperger ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Asbestos Exposure ◽  
Lung Cancer Patients

Asbestos exposure according to different exposure indices among Finnish lung cancer patients

1993 ◽  
Vol 65 (4) ◽  
pp. 269-274 ◽  
Author(s):  
S. Vilkman ◽  
A. Lahdensuo ◽  
J. Mattila ◽  
A. Tossavainen ◽  
T. Tuomi
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Asbestos Exposure ◽  
Lung Cancer Patients

scholarly journals Clinical Characteristics of 64 Lung Cancer Patients with Pleural Plaques

2014 ◽  
Vol 25 ◽  
pp. v95
Author(s):  
Shoichi Kuyama ◽  
Hirotaka Umeno ◽  
Masamoto Nakanishi ◽  
Daisuke Nojima
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Lung Cancer Patients ◽  
Pleural Plaques

Asbestos Exposure Among Primary Lung Cancer Patients In Japan

2010 ◽  
Author(s):  
Narufumi Suganuma ◽  
Akihiko Tamura ◽  
Mitsuhiko Funakoshi ◽  
Kichinori Hasegawa ◽  
Atsushi Ishimine ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Asbestos Exposure ◽  
Primary Lung Cancer ◽  
Lung Cancer Patients

scholarly journals Elemental analysis of histological specimens: a method to unmask nano asbestos fibers

2016 ◽  
Vol 60 (1) ◽  
Author(s):  
M. Scimeca ◽  
A. Pietroiusti ◽  
F. Milano ◽  
L. Anemona ◽  
A. Orlandi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Occupational Exposure ◽  
Cancer Patients ◽  
Asbestos Exposure ◽  
New Method ◽  
Lung Cancer Patients ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
History Of ◽  
Formalin Fixed

<p>There is recent mounting evidence that nanoparticles may have enhanced toxicological potential in comparison to the same material in the bulk form. The aim of this study was to develop a new method for unmask asbestos nanofibers from Formalin-Fixed, Paraffin-Embedded tissue. There is an increasing amount of evidence that nanoparticles may enhance toxicological potential in comparison to the same material in the bulk form. The aim of this study was to develop a new method to unmask asbestos nanofibers from Formalin-Fixed Paraffin-Embedded (FFPE) tissue. For the first time, in this study we applied Energy Dispersive X-ray (EDX) microanalysis through transmission electron microscopy to demonstrate the presence of asbestos nanofibers in histological specimens of patients with possible occupational exposure to asbestos. The diagnostic protocol was applied to 10 randomly selected lung cancer patients with no history of previous asbestos exposure. We detected asbestos nanofibers in close contact with lung cancer cells in two lung cancer patients with previous possible occupational exposure to asbestos. We were also able to identify the specific asbestos iso-type, which in one of the cases was the same rare variety used in the workplace of the affected patient. By contrast, asbestos nanofibers were not detected in lung cancer patients with no history of occupational asbestos exposure. The proposed technique can represent a potential useful tool for linking the disease to previous workplace exposure in uncertain cases. Furthermore, Formalin-Fixed Paraffin-Embedded (FFPE) tissues stored in the pathology departments might be re-evaluated for possible etiological attribution to asbestos in the case of plausible exposure. Since diseases acquired through occupational exposure to asbestos are generally covered by workers’ insurance in most countries, the application of the protocol used in this study may have also relevant social and economic implications. </p>

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