Life-span carcinogenicity studies on Sprague-Dawley rats exposed to γ-radiation: Design of the project and report on the tumor occurrence after post-natal radiation exposure (6 weeks of age) delivered in a single acute exposure

2014 ◽  
Vol 58 (1) ◽  
pp. 46-60 ◽  
Author(s):  
Morando Soffritti ◽  
Eva Tibaldi ◽  
Luciano Bua ◽  
Michela Padovani ◽  
Laura Falcioni ◽  
...  
Keyword(s):  
Life Span ◽  
Radiation Exposure ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Γ Radiation ◽  
Sprague Dawley Rats

Life-span exposure to sinusoidal-50 Hz magnetic field and acute low-dose γ radiation induce carcinogenic effects in Sprague-Dawley rats

2016 ◽  
Vol 92 (4) ◽  
pp. 202-214 ◽  
Author(s):  
Morando Soffritti ◽  
Eva Tibaldi ◽  
Michela Padovani ◽  
David G. Hoel ◽  
Livio Giuliani ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Life Span ◽  
Low Dose ◽  
Sprague Dawley ◽  
Γ Radiation ◽  
Sprague Dawley Rats ◽  
Carcinogenic Effects

scholarly journals Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in Sprague Dawley rats

2018 ◽  
Vol 88 (3-4) ◽  
pp. 199-208
Author(s):  
Elham Nikbakht ◽  
Rosita Jamaluddin ◽  
S. Mohd Redzwan ◽  
Saman Khalesi
Keyword(s):  
Adverse Effect ◽  
Lactobacillus Casei ◽  
Health Effect ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Treatment ◽  
Significant Difference ◽  
Aflatoxin B

Abstract. Aflatoxin B1 (AFB1) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB1 in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB1 only (n = 9); AFB1 treated with LcS (n = 9); and control (no AFB1 exposure) (n = 6) groups. The blood AFB1 level of rats treated with LcS was slightly lower than the untreated AFB1 induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g–1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB1 induced rats. However, a trend for a significant difference was only observed in ALT of AFB1 induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats’ body weight decreased in all animals force-fed with AFB1 with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB1 in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings.

Immunosuppression in weanling and adult Sprague-Dawley rats induced by acute exposure to 3,3′,4,4′-tetrachloroazoxybenzene

Toxicology ◽  
1984 ◽  
Vol 32 (4) ◽  
pp. 287-296 ◽  
Author(s):  
Leon John Olson ◽  
M.T.Stephen Hsia ◽  
Bill L. Kreamer ◽  
Ronald D. Hinsdill
Keyword(s):  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Dosimetry and pathology of 237Np in female rats

1997 ◽  
Vol 16 (2) ◽  
pp. 89-100 ◽  
Author(s):  
W. Sontag ◽  
R. Wirth ◽  
A. Luz ◽  
E. Schäffer ◽  
V. Volf
Keyword(s):  
Body Weight ◽  
Life Span ◽  
The Body ◽  
Female Rats ◽  
Whole Body ◽  
Pathological Examination ◽  
Control Group ◽  
Sprague Dawley ◽  
Weight Group ◽  
Sprague Dawley Rats

Female Sprague-Dawley rats, 10-12-week old and weigh ing about 240 g, were injected intravenously with 237Np nitrate. In the toxicological study 77 rats served as controls and 28 rats per group received single doses of 5.2 and 26 kBq, respectively, per kg body weight. In addition, 12 rats of each injection level, sacrificed at defined points in time, were used for dosimetric studies. During the whole life-span the body weight and 237Np whole body-content of each animal were recorded. After death a detailed pathological examination was made of each animal in the cronical study. One day after injection 48% of the injected activity was in the skeleton, 9.3% in the liver, 3% in the kidneys and 4.4% in the rest of the organs. Whereas in all organs the activity decreased very fast, the half-life in the skeleton was about 1400 days. The bodyweights were comparable in the three groups, but the life span decreased from 800 days (control group) to 644 days after injection (26 kBq kg -1 body weight group). The main lesions in the female rats were mammary tumors (73%) and pituitary gland tumors (52%). With increasing activity the incidence of pituary gland tumors decreased and that of osteosarco mas increased from 1.3% (control group) to 32% (26 kBq kg-1 body weight group), whereas the remaining lesions showed no influence on the activity.

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