Case-control study of male germ cell tumors nested in a cohort of car-manufacturing workers: Findings from the occupational history

2010 ◽  
Vol 53 (10) ◽  
pp. 1006-1018 ◽  
Author(s):  
Ingo Langner ◽  
Nils Schmeißer ◽  
Birte Mester ◽  
Thomas Behrens ◽  
Andrea Gottlieb ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Male Germ Cell ◽  
Occupational History ◽  
Control Study

scholarly journals Parental occupation and childhood germ cell tumors: a case–control study in Denmark, 1968–2016

2021 ◽  
Author(s):  
Clinton Hall ◽  
Johnni Hansen ◽  
Jørn Olsen ◽  
Di He ◽  
Ondine S. von Ehrenstein ◽  
...  
Keyword(s):  
Germ Cell ◽  
Maternal Employment ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Social Contact ◽  
Case Control ◽  
Yolk Sac ◽  
Parental Occupation ◽  
Yolk Sac Tumors ◽  
Control Study

Abstract Purpose To examine associations between parental occupation and childhood germ cell tumors (GCTs) in offspring while distinguishing by common histologic subtype (i.e., yolk sac tumor and teratoma). Methods This population-based case–control study included childhood GCT cases in Denmark diagnosed 1968–2015 (< 16 years old at diagnosis) and sex and birth year-matched controls. Demographic information and parental employment histories were obtained from Danish registries. Parental occupation was assessed by industry; job-exposure matrices were used to examine specific occupational exposures (i.e., potentially carcinogenic organic solvents and social contact). Conditional multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CIs). Results Overall, 178 childhood GCT cases (50 yolk sac tumors; 65 teratomas) and 4,355 controls were included for analysis. Maternal employment in education during pregnancy was associated with offspring GCTs (OR 2.45, 95% CI 1.23–4.90), especially yolk sac tumors (OR 5.27, 95% CI 1.94–14.28). High levels of both maternal and paternal occupational social contact were also associated with offspring yolk sac tumors across all exposure periods (ORs 2.30–4.63). No signals were observed for paternal occupational solvent exposure, while imprecise associations were estimated for maternal exposure (e.g., dichloromethane exposure during pregnancy, OR 1.51, 95% CI 0.77–2.95). Conclusion Our findings suggest that parental occupation is associated with offspring GCTs, with most consistent evidence supporting an association between maternal employment in education or other high social contact jobs and offspring yolk sac tumors.

Molecular markers in extragonadal germ cell tumors (EGCTs): A matched-case control study

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 9700-9700
Author(s):  
M. Nikolaou ◽  
C. Valavanis ◽  
I. Lekka ◽  
G. Aravantinos ◽  
G. Fountzilas ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Germ Cell ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Extragonadal Germ Cell Tumors ◽  
Control Study

scholarly journals Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ligia Rios ◽  
Liliana Vásquez ◽  
Mónica Oscanoa ◽  
Iván Maza ◽  
Jenny Gerónimo
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Solid Tumors ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Paternal Age ◽  
Parental Age ◽  
Advanced Paternal Age ◽  
Control Study

Background. The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors. Methods. We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Odd ratio was used to compare categories of advancing maternal and paternal age with and without adjusting for possible confounding factors were calculated. Results. The risk of childhood retinoblastoma was significantly higher among children of mothers aged> 35 years (adjusted OR 1.21; 95% CI, 1.09-6.08) and fathers aged> 35 years (OR 1.17; 1.01-16.33). A significant trend with increasing mother's age (p = 0.037) and father's age (p = 0.005) was found. There were more risks to development of non-Hodgkin's lymphoma (p = 0.047) and gonadal germ cell tumors (p = 0.04) for advanced paternal age. There was a strong protective effect of increasing parity on risk of solid tumors in children (p=0.0015). Conclusion. Our results suggest that advanced parental age is associated with the risk for the development of retinoblastoma. Advanced paternal age increases the risk of non-Hodgkin lymphoma and gonadal germ cell tumor. The higher the order of birth of the children, the less the chance of developing any neoplasm.

scholarly journals Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Aurélie M. N. Danjou ◽  
Olivia Pérol ◽  
Astrid Coste ◽  
Elodie Faure ◽  
Rémi Béranger ◽  
...  
Keyword(s):  
Germ Cell ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Germ Cell Tumors ◽  
Developed Countries ◽  
Case Control ◽  
Testicular Germ Cell ◽  
Increased Risk ◽  
Domestic Use ◽  
Control Study

Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. Methods We conducted a case-control study of 304 TGCT cases, aged 18–45 years old, recruited in 20 French university hospitals, and 274 controls frequency-matched on hospital and birth year. Participants’ mothers provided information on their domestic use of pesticides from 1 year before start of pregnancy to 1 year after their son’s birth, for gardening activities, treatment of indoor plants, pets, wood and mold, and pest control. Odds ratios (OR) for TGCT (overall and by histological subtype) and 95% confidence intervals (CI) were estimated using conditional logistic regression. Results Prevalence of reported domestic use of pesticides was 77.3% for insecticides, 15.9% for fungicides and 12.1% for herbicides. While no association was found for any use of insecticides (OR = 1.27, CI = 0.80–2.01) or herbicides (OR = 1.15, CI = 0.67–2.00), elevated risks of TGCT overall (OR = 1.73, CI = 1.04–2.87) and non-seminoma subtype (OR = 2.44, CI = 1.26–4.74) were observed for any use of fungicides. When specific purposes were examined, using fungicides and/or insecticides for woodwork (OR = 2.35, CI = 1.06–5.20) and using insecticides on cats and dogs (OR = 1.95, CI = 1.12–3.40) were associated with increased risk of non-seminoma subtype. We found no association for seminoma subtype. Conclusions Although recall bias may partially explain the elevated ORs, our study provides some evidence of a positive association between domestic use of pesticides during early periods of development, particularly fungicides and risk of adult TGCT and non-seminoma. Given the common domestic use of pesticides in France, further research on TGCT risk is warranted.

Factors associated with non-epithelial ovarian cancer among Mexican women: A matched case-control study

2003 ◽  
Vol 13 (6) ◽  
pp. 756-763
Author(s):  
L. M. Sanchez-Zamorano ◽  
E. Salazar-Martinez ◽  
P. Escudero-De Los Rios ◽  
G. Gonzalez-Lira ◽  
L. Flores-Luna ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Germ Cell ◽  
Epithelial Ovarian Cancer ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Full Term ◽  
Mexican Women ◽  
Factors Associated ◽  
Control Study

The purpose of this study was to identify risk factors associated with the development of non-epithelial ovarian cancer in Mexican women. A case-control study was carried out on women registered with the Mexican Institute of Social Security in Mexico City over a period of two years (1995–97). Twenty-eight new cases were recruited from the Gynecology and Obstetrics Hospital no. 4, “Luis Castelazo Ayala”, and were matched by age with 84 controls selected randomly. Eighteen (64.3%) cases of germ cell tumors and 10 (35.7%) stromal sex cord tumors were found. The number of full term pregnancies was associated inversely to development of stromal sex cord tumors with lower risk in women with more than three full term pregnancies (odds ratio, 0.02: 95% confidence interval, 0.001–0.56) compared to nulliparous women. No associations were found respecting to germ cell tumors. Parity was inversely associated to development of stromal sex cord tumors, probably as a result of the endocrine system's influence on the ovaries. The development of germ cell tumors could be associated to factors not evaluated in this study.

The Inter-Regional, Epidemiological Study of Childhood Cancer (IRESCC): case-control study in children with germ cell tumours

1986 ◽  
Vol 7 (5) ◽  
pp. 717-722 ◽  
Author(s):  
H.E. Johnston ◽  
J.R. Mann ◽  
J. Williams ◽  
J.A.H. Waterhouse ◽  
J.M. Birch ◽  
...  
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Epidemiological Study ◽  
Case Control Study ◽  
Case Control ◽  
Germ Cell Tumours ◽  
Control Study
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