Nested case-control study of external ionizing radiation dose and mortality from dementia within a pooled cohort of female nuclear weapons workers

2003 ◽  
Vol 44 (4) ◽  
pp. 351-358 ◽  
Author(s):  
Ralph F. Sibley ◽  
Beth S. Moscato ◽  
Gregg S. Wilkinson ◽  
Nachimuthu Natarajan
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Nuclear Weapons ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235658 ◽  
Author(s):  
Elisa Pasqual ◽  
Michelle C. Turner ◽  
Esther Gracia-Lavedan ◽  
Delphine Casabonne ◽  
Yolanda Benavente ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Case Control Study ◽  
Diagnostic Procedures ◽  
Case Control ◽  
Medical Diagnostic ◽  
Control Study ◽  
Lymphoma Risk

A Nested Case-Control Study of Leukemia Mortality and Ionizing Radiation at the Portsmouth Naval Shipyard

2005 ◽  
Vol 164 (6) ◽  
pp. 810-819 ◽  
Author(s):  
Travis L. Kubale ◽  
Robert D. Daniels ◽  
James H. Yiin ◽  
James Couch ◽  
Mary K. Schubauer-Berigan ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Circulatory disease in French nuclear fuel cycle workers chronically exposed to uranium: a nested case–control study

2017 ◽  
Vol 75 (4) ◽  
pp. 270-276 ◽  
Author(s):  
Sergey Zhivin ◽  
Irina Guseva Canu ◽  
Estelle Davesne ◽  
Eric Blanchardon ◽  
Jérôme-Philippe Garsi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radiation Dose ◽  
Low Dose ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Case Control ◽  
Γ Radiation ◽  
Circulatory System Diseases ◽  
Nested Case Control ◽  
Control Study

ObjectivesThere is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case–control study of French AREVA NC Pierrelatte nuclear workers employed between 1960 and 2005 to estimate CSD risks adjusting for major CSD risk factors (smoking, blood pressure, body mass index, total cholesterol and glycaemia) and external γ-radiation dose.MethodsThe study included 102 cases of death from CSD and 416 controls individually matched on age, gender, birth cohort and socio-professional status. Information on CSD risk factors was collected from occupational medical records. Organ-specific absorbed doses were estimated using biomonitoring data, taking into account exposure regime and uranium physicochemical properties. External γ-radiation was measured by individual dosimeter badges. Analysis was conducted with conditional logistic regression.ResultsWorkers were exposed to very low radiation doses (mean γ-radiation dose 2 and lung uranium dose 1 mGy). A positive but imprecise association was observed (excess OR per mGy 0.2, 95% CI 0.004 to 0.5). Results obtained after adjustment suggest that uranium exposure might be an independent CSD risk factor.ConclusionsOur results suggest that a positive association might exist between internal uranium exposure and CSD mortality, not confounded by CSD risk factors. Future work should focus on numerous uncertainties associated with internal uranium dose estimation and on understanding biological pathway of CSD after protracted low-dose internal radiation exposure.

A Nested Case-Control Study of Lung Cancer Risk and Ionizing Radiation Exposure at the Portsmouth Naval Shipyard

2007 ◽  
Vol 168 (3) ◽  
pp. 341-348 ◽  
Author(s):  
James H. Yiin ◽  
Sharon R. Silver ◽  
Robert D. Daniels ◽  
Dennis D. Zaebst ◽  
Evelyn A. Seel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Risk ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Case Control Study ◽  
Lung Cancer Risk ◽  
Case Control ◽  
Ionizing Radiation Exposure ◽  
Nested Case Control ◽  
Control Study

scholarly journals Correction: Association of ionizing radiation dose from common medical diagnostic procedures and lymphoma risk in the Epilymph case-control study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243396
Author(s):  
Elisa Pasqual ◽  
Michelle C Turner ◽  
Esther Gracia-Lavedan ◽  
Delphine Casabonne ◽  
Yolanda Benavente ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Ionizing Radiation ◽  
Case Control Study ◽  
Diagnostic Procedures ◽  
Case Control ◽  
Medical Diagnostic ◽  
Control Study ◽  
Lymphoma Risk

Identification of genetic predispositions related to ionizing radiation in primary human skin fibroblasts from survivors of childhood and second primary cancer as well as cancer-free controls: Protocol for the nested case-control study KiKme. (Preprint)

2021 ◽  
Author(s):  
Manuela Marron ◽  
Lara Kim Brackmann ◽  
Heike Schwarz ◽  
Willempje Hummel-Bartenschlager ◽  
Sebastian Zahnreich ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Childhood Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Second Primary ◽  
Human Skin Fibroblasts ◽  
Skin Biopsies ◽  
Nested Case Control ◽  
Control Study

BACKGROUND Therapy of a first primary neoplasm (FPN) in childhood with high doses of ionizing radiation is an established risk factor for second primary neoplasms (SPN). An association between exposure to low doses and childhood cancer is also suggested, however, results are inconsistent. As only subgroups of children with FPNs develop SPNs, an interaction between radiation, genetic, and other risk factors is presumed to influence cancer development. OBJECTIVE Therefore, the population-based nested case-control study KiKme aims to identify differences in genetic predispositions and radiation-response between childhood cancer survivors with and without SPNs as well as cancer-free controls. METHODS We conducted a population-based nested case-control study KiKme. Besides questionnaire information, skin biopsies and saliva samples are available. By measuring individual reactions to different exposures of radiation (e.g., 0.05 and 2 Gray) in normal somatic cells of the same person, our design enables us to create several exposure scenarios for the same person simultaneously and measure several different molecular markers (e.g., deoxyribonucleic acid (DNA), messenger RNA, long non-coding RNA, copy number variation). RESULTS Since 2013, 101 out of 247 invited SPN patients, 340 out of 1,729 invited FPN patients, and 150 out of 246 invited cancer-free controls were recruited and matched by age and sex. Childhood cancer patients were additionally matched by tumor morphology, year of, and age at diagnosis. Participants reported on lifestyle, socio-economical and anthropometric factors, as well as on medical radiation history, health, and family history of diseases (N = 556). Primary human fibroblasts from skin biopsies of the participants were cultivated (N = 499) and cryopreserved (N = 3,886). DNA was extracted from fibroblasts (N = 488) and saliva (N = 510). CONCLUSIONS This molecular-epidemiological study is the first to combine observational epidemiological research with standardized experimental components in primary human skin fibroblasts to identify genetic predispositions related to ionizing radiation in childhood and SPNs. In the future, fibroblasts of the participants will be used for standardized irradiation experiments, which will inform analysis of the case-control study and vice versa. Differences between participants will be identified using several molecular markers. With its innovative combination of experimental and observational components, this new study will provide valuable data to forward research on radiation-related risk factors in childhood cancer and SPNs.

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